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Supportive Care in Cancer

, Volume 22, Issue 7, pp 1999–2007 | Cite as

A systematic review on chronic oxaliplatin-induced peripheral neuropathy and the relation with oxaliplatin administration

  • A. J. M. Beijers
  • F. Mols
  • G. VreugdenhilEmail author
Review Article

Abstract

Purpose

The aim of this study was to systematically review the literature on the influence of oxaliplatin administration (e.g. cumulative dose, dose intensity, number of cycles and combination regimen) on the long-term prevalence of oxaliplatin-induced peripheral neuropathy (O-IPN) at least 12 months after termination of chemotherapy.

Methods

A computerized search of literature on databases PubMed and Cochrane was performed. Published original articles were included if they reported about long-term O-IPN and gave concomitant information about oxaliplatin therapy given to the patients. All articles were assessed for quality.

Results

We included 14 articles (n = 3,869 patients), and the majority of these studies were of high quality. All included patients who were treated for colorectal cancer, mainly with oxaliplatin in combination with 5-fluorouracil/leucovorin. Median cumulative doses and dose intensity varied between 676 and 1,449 mg/m2 and 30.8 and 42.6 mg/m2/week, respectively. Neuropathy assessment differed between studies, and the National Cancer Institute-Common Terminology Criteria (NCI-CTC) was used most often. The degree of neuropathy ranged from grade 0 to 3. Only six studies directly assessed the relationship between oxaliplatin administration and neuropathy. Of these studies, five did find a relation between neuropathy and higher cumulative dose, while one study did not find a relation.

Conclusions

O-IPN is still present in a great amount of patients in ≥12 months after termination of therapy. A higher cumulative dose is likely to have an influence on the development of long-term O-IPN. More studies are needed that assess long-term neuropathy and oxaliplatin administration by means of validated neuropathy assessments.

Keywords

Cancer Chronic Chemotherapy Neurotoxicity Oxaliplatin Peripheral neuropathy 

Notes

Acknowledgments

Floortje Mols was supported by a VENI grant (no. 451-10-041) from the Netherlands Organization for Scientific Research (The Hague, The Netherlands).

Conflict of interest

None

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Internal MedicineMáxima Medical CentreVeldhovenThe Netherlands
  2. 2.Center of Research on Psychology in Somatic Diseases (CoRPS), Department of Medical and Clinical PsychologyTilburg UniversityTilburgThe Netherlands
  3. 3.Comprehensive Cancer Centre Netherlands (CCCN)Eindhoven Cancer RegistryEindhovenThe Netherlands
  4. 4.Department of Medical OncologyMaastricht University Medical CentreMaastrichtThe Netherlands

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