Exercise training in patients with advanced gastrointestinal cancer undergoing palliative chemotherapy: a pilot study
- 1.6k Downloads
This pilot study aimed to investigate the feasibility of two different training programs in patients with advanced gastrointestinal cancer undergoing palliative chemotherapy. Potential effects of training programs on the patients’ quality of life, physical performance, physical activity in daily living, and biological parameters were exploratorily evaluated.
Patients were randomly assigned to a resistance (RET) and aerobic exercise training group (AET). Both underwent supervised training sessions twice a week for 12 weeks. RET was performed at 60–80 % of the one-repetition maximum and consisted of 2–3 sets of 15–25 repetitions. The AET group performed endurance training at 60–80 % of their predetermined pulse rate (for 10 to 30 min).
A total of 26 gastrointestinal cancer patients could be randomized. Twenty-one patients completed the 12 weeks of intervention. The median adherence rate to exercise training of all 26 patients was 65 %, while in patients who were able to complete 12 weeks, adherence was 75 %. The fatigue score of all patients decreased from 66 to 43 post-intervention. Sleeping duration increased in both groups and muscular strength increased in the RET group. A higher number of steps in daily living was associated with higher levels of physical and social functioning as well as lower scores for pain and fatigue.
RET and AET are feasible in gastrointestinal cancer patients undergoing palliative chemotherapy. Both training programs seem to improve cancer-related symptoms as well as the patient’s physical activities of daily living.
KeywordsGastrointestinal cancer palliative chemotherapy quality of life resistance exercise training aerobic exercise training physical performance
We would like to thank the patients who devoted their precious time to participate in the study. We thank the foundation “Stiftung Leben mit Krebs®” for their support.
Conflict of interest
The authors have no conflicts of interest.
- 7.Meyerhardt JA, Ogino S, Kirkner GJ, Chan AT, Wolpin B, Ng K, Nosho K, Shima K, Giovannucci EL, Loda M, Fuchs CS (2009) Interaction of molecular markers and physical activity on mortality in patients with colon cancer. Clin Cancer Res 15:5931–5936. doi: 10.1158/1078-0432.CCR-09-0496 PubMedCentralPubMedCrossRefGoogle Scholar
- 10.Allgayer H, Owen RW, Spiegelhalder B, Streit J, Reichel C, Bartsch H (2008) Short-term moderate exercise programs reduce oxidative DNA damage as determined by high-performance liquid chromatography-electrospray ionization-mass spectrometry in patients with colorectal carcinoma following primary treatment. Scand J Gastroenterol 43:971–978. doi: 10.1080/00365520701766111 PubMedCrossRefGoogle Scholar
- 12.Lee DH, Kim JY, Lee MK, Lee C, Min JH, Jeong DH, Lee JW, Chu SH, Meyerhardt JA, Ligibel J, Jones LW, Kim NK, Jeon JY (2013) Effects of a 12-week home-based exercise program on the level of physical activity, insulin, and cytokines in colorectal cancer survivors: a pilot study. Support Care Cancer 21:2537–2545. doi: 10.1007/s00520-013-1822-7 PubMedCrossRefGoogle Scholar
- 15.Cheville AL, Kollasch J, Vandenberg J, Shen T, Grothey A, Gamble G, Basford JR (2013) A home based exercise program to improve function, fatigue, and sleep quality in patients with stage IV lung and colorectal cancer. A randomized controlled trial. J Pain Symptom Manage 45:811–821. doi: 10.1016/j.jpainsymman.2012.05.006 PubMedCrossRefGoogle Scholar
- 21.Jones L, Fitzgerald G, Leurent B, Round J, Eades J, Davis S, Gishen F, Holman A, Hopkins K, Tookman A (2012) Rehabilitation in advanced, progressive, recurrent cancer: a randomized controlled trial. J Pain Symptom Manage 46:315–325. doi: 10.1016/j.jpainsymman.2012.08.017 PubMedCrossRefGoogle Scholar
- 30.Oldervoll LM, Loge JH, Lydersen S, Paltiel H, Asp MB, Nygaard UV, Oredalen E, Frantzen TL, Lesteberg I, Amundsen L, Hjermstad MJ, Haugen DF, Paulsen Ø, Kaasa S (2011) Physical exercise for cancer patients with advanced disease: a randomized controlled trial. Oncologists 6:1649–1657. doi: 10.1634/theoncologist.2011-0133 CrossRefGoogle Scholar
- 33.Borg G (1998) Borg’s perceived exertion and pain scales. Human Kinetics, ChampaignGoogle Scholar
- 35.Landers J (1985) Maximums based on reps. Nat Strength Cond 6:60–61Google Scholar
- 36.Malavolti M, Pietrobelli A, Dugoni M et al (2005) A new device for measuring daily total energy expenditure in free living individuals. Int J Body Compos Res 3:63Google Scholar
- 37.Patel SA, Slivka WA, Sciurba FC (2004) Validation of a wearable body monitoring device in COPD. Am J Respir Crit Care Med 30:A771Google Scholar