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Supportive Care in Cancer

, Volume 22, Issue 1, pp 3–6 | Cite as

Caphosol, a therapeutic option in case of cancer therapy-induced oral mucositis in children?

Results from a prospective multicenter double blind randomized controlled trial
  • M. F. RaphaelEmail author
  • A. M. den Boer
  • W. J. W. Kollen
  • H. Mekelenkamp
  • F. C. H. Abbink
  • G. J. L. Kaspers
  • K. Zomer-Kooijker
  • B. H. W. Molmans
  • W. J. E. Tissing
Letter to the editor

Introduction

In pediatric oncology, chemotherapy- or radiotherapy-induced oral mucositis (OM) is accompanied by decreased oral intake, pain, analgesics use, and hospital admission [1, 2]. Moreover, OM is correlated with an increased risk of sepsis [3, 4]. Recently, Caphosol, a supersaturated Ca2+/PO43− mouth rinse, became available to prevent or treat mucositis [5]. Papas et al. demonstrated Caphosol to have a beneficial prophylactic effect in adult hematopoietic stem cell transplantation (HSCT) patients, but evidence in pediatric patients is lacking [6]. We studied whether Caphosol can be used to treat OM in a prospective randomized study.

Patients and methods

Patients and settings

Four university hospitals in The Netherlands participated, and Institutional Review Board (IRB) approval was obtained. Pediatric cancer patients aged 4–18 years old were enrolled from January 2011 until March 2012 before the start of chemotherapy or HSCT. Once mucositis occurred, patients were randomized to...

Keywords

Hematopoietic Stem Cell Transplantation Oral Mucositis Mouth Rinse Palifermin Obtain Blood Culture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

Study medications were sponsored by EUSA Pharma (international division of Jazz Pharmaceuticals).

Conflict of interest

The authors have declared no conflicts of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • M. F. Raphael
    • 1
    Email author
  • A. M. den Boer
    • 1
  • W. J. W. Kollen
    • 2
  • H. Mekelenkamp
    • 2
  • F. C. H. Abbink
    • 3
  • G. J. L. Kaspers
    • 3
  • K. Zomer-Kooijker
    • 4
  • B. H. W. Molmans
    • 5
  • W. J. E. Tissing
    • 6
  1. 1.Department of Pediatric Hematology and Oncology, Wilhelmina Children’s HospitalUniversity Medical Center UtrechtUtrechtThe Netherlands
  2. 2.Department of Pediatric Hematology and OncologyLeiden University Medical CenterLeidenThe Netherlands
  3. 3.Department of Pediatric Hematology and OncologyVU University Medical CenterAmsterdamThe Netherlands
  4. 4.Department of Pediatrics, Wilhelmina Children’s HospitalUniversity Medical Center UtrechtUtrechtThe Netherlands
  5. 5.Department of Hospital and Clinical Pharmacy, Beatrix Children’s Hospital, University Medical Center GroningenUniversity of GroningenGroningenThe Netherlands
  6. 6.Department of Pediatric Hematology and Oncology, Beatrix Children’s Hospital, University Medical Center GroningenUniversity of GroningenGroningenThe Netherlands

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