Caphosol, a therapeutic option in case of cancer therapy-induced oral mucositis in children?
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In pediatric oncology, chemotherapy- or radiotherapy-induced oral mucositis (OM) is accompanied by decreased oral intake, pain, analgesics use, and hospital admission [1, 2]. Moreover, OM is correlated with an increased risk of sepsis [3, 4]. Recently, Caphosol, a supersaturated Ca2+/PO43− mouth rinse, became available to prevent or treat mucositis . Papas et al. demonstrated Caphosol to have a beneficial prophylactic effect in adult hematopoietic stem cell transplantation (HSCT) patients, but evidence in pediatric patients is lacking . We studied whether Caphosol can be used to treat OM in a prospective randomized study.
Patients and methods
Patients and settings
Four university hospitals in The Netherlands participated, and Institutional Review Board (IRB) approval was obtained. Pediatric cancer patients aged 4–18 years old were enrolled from January 2011 until March 2012 before the start of chemotherapy or HSCT. Once mucositis occurred, patients were randomized to...
KeywordsHematopoietic Stem Cell Transplantation Oral Mucositis Mouth Rinse Palifermin Obtain Blood Culture
Study medications were sponsored by EUSA Pharma (international division of Jazz Pharmaceuticals).
Conflict of interest
The authors have declared no conflicts of interest.
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