The symptom burden of non-small cell lung cancer in the USA: a real-world cross-sectional study
- 918 Downloads
Disease symptom management in patients with advanced non-small cell lung cancer (NSCLC) is a critical aspect of therapy. The main objective of our study was to assess patient-reported outcomes and the degree of concordance between physician and patient perceptions of symptom severity in advanced NSCLC in the USA.
Patients with advanced (stage IIIB/IV) NSCLC (N = 450) were recruited in a nationwide (USA) lung cancer study. Patients and their oncologists completed patient and physician versions of the Lung Cancer Symptom Scale (LCSS). Patient-reported lung cancer-specific quality of life was assessed with the Functional Assessment of Cancer Therapy—Lung (FACT-L). Concordance was assessed using the kappa-statistic. Regression analysis was performed with FACT-L total score as the dependent variable and patient-reported LCSS symptom scores as predictors.
A high proportion of patients experienced lung cancer symptoms: fatigue (100 %), loss of appetite (97 %), shortness of breath (95 %), cough (93 %), pain (92 %), and blood in sputum (63 %). Concordance between physician and patients was lowest for loss of appetite (kappa 0.1701) and greatest for hemoptysis (kappa 0.4586). Loss of appetite (β = −0.204; p < 0.001), cough (β = −0.145; p < 0.01), pain (β = −0.265; p < 0.001), and shortness of breath (β = −0.145; p < 0.01) were found to be significant predictors of the quality of life.
Symptom burden in patients with advanced NSCLC is high and has a negative impact on the quality of life. Patient-reported outcomes data could help optimize disease outcomes and therapy management in NSCLC.
KeywordsNon-small cell lung cancer Symptom burden Quality of life Concordance Patient-reported outcomes
- 1.National Comprehensive Cancer Network (NCCN). Non-small cell lung cancer. NCCN Guidelines, version 3.2012. Available at: http://www.nccn.org. Accessed July 2012
- 2.Surveillance Epidemiology and End Results (SEER). SEER Stat Fact Sheets: lung and bronchus. Available at: http://seer.cancer.gov/statfacts/html/lungb.html. Accessed July 2012
- 11.Quinten C, Maringwa J, Gotay CC, Martinelli F, Coens C, Reeve BB, Flechtner H, Greimel E, King M, Osoba D, Cleeland C, Ringash J, Schmucker-Von Koch J, Taphoorn MJ, Weis J, Bottomley A (2011) Patient self-reports of symptoms and clinician ratings as predictors of overall cancer survival. J Natl Cancer Inst 103:1851–1858PubMedCrossRefGoogle Scholar