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Supportive Care in Cancer

, Volume 21, Issue 9, pp 2537–2545 | Cite as

Effects of a 12-week home-based exercise program on the level of physical activity, insulin, and cytokines in colorectal cancer survivors: a pilot study

  • Dong Hoon Lee
  • Ji Young Kim
  • Mi Kyung Lee
  • Choae Lee
  • Ji-Hee Min
  • Duck Hyoun Jeong
  • Ji-Won Lee
  • Sang Hui Chu
  • Jeffrey A. Meyerhardt
  • Jennifer Ligibel
  • Lee W. Jones
  • Nam Kyu Kim
  • Justin Y. JeonEmail author
Original Article

Abstract

Purpose

The purposes of this study are to examine (1) the feasibility and efficacy of two different home-based exercise protocols on the level of physical activity (PA), and (2) the effect of increased PA via home-based exercise program on biomarkers of colorectal cancer.

Methods

Seventeen patients (age 55.18 ± 13.3 years) with stage II–III colorectal cancer completed the 12-week home-based exercise program. Subjects were randomized into either casually intervened home-based exercise group (CIHE) or intensely intervened home-based exercise group (IIHE). The primary outcome was the level of PA. Furthermore, insulin, homeostasis model assessment of insulin resistance, insulin-like growth factor axis, and adipocytokines were measured.

Results

Both CIHE and IIHE program significantly increased the level of PA at 12 weeks compared to its level at baseline (CIHE, 10.00 ± 8.49 vs. 46.07 ± 45.59; IIHE, 12.08 ± 11.04 vs. 35.42 ± 27.42 MET hours per week). Since there was no difference in PA change between groups (p = 0.511), the data was combined in analyzing the effects of increased PA on biomarkers. Increase in PA significantly reduced insulin (6.66 ± 4.58 vs. 4.86 ± 3.48 μU/ml, p = 0.006), HOMA-IR (1.66 ± 1.23 vs. 1.25 ± 1.04, p = 0.017), and tumor necrosis alpha-α (TNF-α 4.85 ± 7.88 vs. 2.95 ± 5.38 pg/ml, p = 0.004), and significantly increased IGF-1 (135.39 ± 60.15 vs. 159.53 ng/ml, p = 0.007), IGF binding protein (IGFBP)-3 (2.67 ± 1.48 vs. 3.48 ± 1.00 ng/ml, p = 0.013), and adiponectin (6.73 ± 3.07 vs. 7.54 ± 3.96 μg/ml, p = 0.015).

Conclusion

CIHE program was as effective as IIHE program in increasing the level of PA, and the increase in PA resulted in significant change in HOMA-IR, IGF-1 axis, TNF-α, and adiponectin levels in stage II–III colorectal cancer survivors.

Keywords

Colorectal cancer Exercise Insulin resistance IGFs Cytokine 

Notes

Research support

National Research Foundation of Korea (NRF) (No. 2011-0004892 to J.Y.J.) and the National R & D program for Cancer Control, Ministry of Health and Welfare, Republic of Korea (1120230 to N.K.K).

Conflict of interest

No author has declared conflicts of interest. The authors have full control of all primary data and that we agree to allow the journal to review the data if required.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Dong Hoon Lee
    • 1
  • Ji Young Kim
    • 1
  • Mi Kyung Lee
    • 1
  • Choae Lee
    • 1
  • Ji-Hee Min
    • 1
  • Duck Hyoun Jeong
    • 2
  • Ji-Won Lee
    • 3
  • Sang Hui Chu
    • 4
  • Jeffrey A. Meyerhardt
    • 5
  • Jennifer Ligibel
    • 5
  • Lee W. Jones
    • 6
  • Nam Kyu Kim
    • 2
  • Justin Y. Jeon
    • 1
    • 7
    Email author
  1. 1.Department of Sport and Leisure StudiesYonsei University College of EducationSeoulKorea
  2. 2.Department of SurgeryYonsei University College of MedicineSeoulKorea
  3. 3.Department of Family MedicineYonsei University College of MedicineSeoulKorea
  4. 4.Department of Clinical Nursing Science, Nursing Policy and Research Institute, Biobehavioral Research CenterYonsei University College of NursingSeoulKorea
  5. 5.Department of Medical Oncology, Dana Farber Cancer InstituteHarvard Medical SchoolBostonUSA
  6. 6.Duke University Medical CenterDurhamUSA
  7. 7.Department of Sport and Leisure StudiesYonsei UniversitySeoulKorea

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