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Supportive Care in Cancer

, Volume 21, Issue 5, pp 1421–1428 | Cite as

Effect of low-level laser therapy on patient reported measures of oral mucositis and quality of life in head and neck cancer patients receiving chemoradiotherapy—a randomized controlled trial

  • Ajay Prashad GautamEmail author
  • Donald J. Fernandes
  • Mamidipudi S. Vidyasagar
  • Arun G. Maiya
  • Shantling Nigudgi
Original Article

Abstract

Purpose

Chemoradiotherapy (CRT)-induced oral mucositis (OM) adversely affects a patient’s oral functions and quality of life (QOL). Low-level laser therapy (LLLT) showed some preventive and curative effects against clinically reported objective measures of OM in few trials including our recently published study. There is dearth of evidence regarding the effects of LLLT on patient’s subjective experience of OM and QOL. Hence, we did this study to evaluate the effects of LLLT on a patient’s reported measures of OM and QOL in head and neck cancer (HNC) patients receiving CRT.

Methods

This triple blinded study randomized 220 HNC patients scheduled for CRT (three weekly Cisplatin + RT = 66 Gray (2 Gy/session), five fractions/week for 6.5 weeks, total 33 fractions) into laser (110) and placebo (110) groups. The laser group received LLLT (Technomed Electronics Advanced Laser Therapy 1000, He–Ne, λ = 632.8 nm, power density = 24 mW/cm2, dosage = 3.0 J at each point, total dose/session = 36–40 J, spot size 1 cm2, irradiation time/point 125 s) before each radiation session, while the placebo group did not receive laser therapy. Methodology was similar to our recently published study (Gautam et al. Radiother Oncol 104:349–354, 2012). In this part of our study, a blinded assessor collected subjective outcomes of the patient’s reported measures of OM using Oral Mucositis Weekly Questionnaire-Head and Neck (OMWQ-HN) and QOL using Functional Assessment of Cancer Treatment-Head and Neck (FACT-HN) Questionnaire. Data were analyzed using repeated measure ANOVA through general linear model. Statistical significance was kept at p < 0.05.

Results

Results analysis revealed that OMWQ-HN (F = 12.199, df = 6,1314, p < 0.001) and FACT-HN (p < 0.05) scores were significantly lower in LLLT than placebo group patients. Also, a significant reduction (p < 0.001) in incidence of severe OM, need for opioid analgesics, and total parenteral nutrition was observed.

Conclusions

LLLT was effective in improving the patient’s subjective experience of OM and QOL in HNC patients receiving CRT.

Keywords

Chemoradiotherapy Head and neck cancer Low-level laser therapy Oral mucositis Oral mucositis weekly questionnaire-head and neck Quality of life Randomized controlled trial 

Notes

Acknowledgments

Our sincere thanks to the Department of Atomic Energy-Board of Research in Nuclear Sciences, Government of India for the financial support during the study.

Conflict of interest

None

Funding

This study was funded by the Department of Atomic Energy-Board of Research in Nuclear Sciences, Government of India [DAE-BRNS project ref no. 2008/35/1/BRNS dated 23/10/2008]. Funding source had no role in this study other than providing financial support during the trial.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Ajay Prashad Gautam
    • 1
    Email author
  • Donald J. Fernandes
    • 1
  • Mamidipudi S. Vidyasagar
    • 2
  • Arun G. Maiya
    • 1
  • Shantling Nigudgi
    • 3
  1. 1.Department of Radiotherapy and Oncology, Kasturba Medical College and HospitalManipal UniversityManipalIndia
  2. 2.Department of Radiotherapy and OncologyFather Muller Medical CollegeMangaloreIndia
  3. 3.Department of Radiotherapy and OncologyApollo Cancer HospitalHyderabadIndia

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