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Supportive Care in Cancer

, Volume 21, Issue 5, pp 1313–1319 | Cite as

Identification of clinical predictive factors of oxaliplatin-induced chronic peripheral neuropathy in colorectal cancer patients treated with adjuvant Folfox IV

  • Bruno Vincenzi
  • Anna Maria Frezza
  • Gaia Schiavon
  • Chiara SpotoEmail author
  • Raffaele Addeo
  • Vincenzo Catalano
  • Francesco Graziano
  • Daniele Santini
  • Giuseppe Tonini
Original Article

Abstract

Purpose

Oxaliplatin-induced neuropathy is a dose-related side effect which occurs in almost 40 % of patients treated with oxaliplatin. Aim of the present study was to identify reliable clinical factors predicting its development and duration.

Methods

One hundred sixty-nine completely resected colorectal cancer patients treated with adjuvant Folfox IV regimen were retrospectively included. The following pre-treatment clinical parameters were collected: hypocalcaemia, hypomagnesaemia, hypoalbuminaemia, anaemia, diabetes, chronic renal failure (CRF), folate deficiency, vitamin B12 deficiency, number of cycles received and habit to alcohol consumption. Incidence, grade (NCI-CTCAE v.3) and duration of neuropathy were recorded.

Results

Incidence of neuropathy was found to be higher in patients with pre-treatment anaemia (p = 0.001), hypoalbuminaemia (p = 0.01) and hypomagnesaemia (p = 0.001) as well in those with habit to alcohol consumption (p = 0.003). Neuropathy durations were conversely associated with age, being longer in younger patients (p = 0.03), and again with hypoalbuminaemia (p = 0.04) and hypomagnesaemia (p = 0.002). No correlation was found with gender, hypocalcaemia, diabetes and CRF. The correlation between vitamin B12 and folate levels and the development of neurotoxicity were not analysed because of the high number of missing data in the population.

Conclusions

Age, anaemia, hypoalbuminaemia, hypomagnesaemia and alcohol consumption are reliable and easily assessable clinical factors predicting incidence and length of oxaliplatin-induced neuropathy.

Keywords

Oxaliplatin-induced neuropathy Colorectal cancer Neurotoxicity Clinical predictive factors 

Notes

Conflict of interest

Authors have not any conflict of interest to declare.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Bruno Vincenzi
    • 1
  • Anna Maria Frezza
    • 1
  • Gaia Schiavon
    • 2
  • Chiara Spoto
    • 1
    Email author
  • Raffaele Addeo
    • 3
  • Vincenzo Catalano
    • 4
  • Francesco Graziano
    • 5
  • Daniele Santini
    • 1
  • Giuseppe Tonini
    • 1
  1. 1.Medical OncologyUniversità Campus Bio-MedicoRomeItaly
  2. 2.Department of Medical OncologyErasmus University Medical Center–Daniel den Hoed Cancer CenterRotterdamNetherlands
  3. 3.Ospedale San Giovanni Di DioFrattaminoreItaly
  4. 4.UOC OncologiaA.O. “Ospedali Riuniti Marche Nord”PesaroItaly
  5. 5.Dipartimento di Medicina OncologicaOspedale di UrbinoUrbinoItaly

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