Supportive Care in Cancer

, Volume 20, Issue 6, pp 1147–1158 | Cite as

Acupuncture for the treatment of cancer pain: a systematic review of randomised clinical trials

  • Tae-Young Choi
  • Myeong Soo Lee
  • Tae-Hun Kim
  • Christopher Zaslawski
  • Edzard Ernst
Review Article



Controlling cancer-related pain is an important component in the palliative care of cancer patients. The objective of this review was to assess the effectiveness of acupuncture for treating cancer pain.


Fourteen databases were searched from their inception through April 2011. Randomised clinical trials (RCTs) were included if acupuncture was used as the sole treatment or as a part of a combination therapy for cancer pain. Studies were included if they were controlled with a placebo or controlled against a drug-therapy or no-treatment group. The Cochrane criteria were used to assess the risk of bias.


A total of 15 RCTs met our inclusion criteria. All of the included RCTs were associated with a high risk of bias. The majority of acupuncture treatments or combination therapies with analgesics exhibited favourable effects compared with conventional treatments in individual studies. However, a meta-analysis suggested that acupuncture did not generate a better effect than drug therapy (n = 886; risk ratio (RR), 1.12; 95% CI 0.98 to 1.28; P = 0.09). The comparison between acupuncture plus drug therapy and drug therapy alone demonstrated a significant difference in favour of the combination therapy (n = 437; RR, 1.36; 95% CI 1.13 to 1.64; P = 0.003). The results of this systematic review provide no strong evidence for the effectiveness of acupuncture in the management of cancer pain.


The total number of RCTs included in the analysis and their methodological quality were too low to draw firm conclusions. Future rigorous RCTs will be necessary to assess the clinical efficacy of acupuncture in this area.


Acupuncture Cancer pain Systematic review Complementary and alternative medicine 



Tae-Young Choi and Myeong Soo Lee were supported by Korea Institute of Oriental Medicine (K11111 and K11130).

Conflict of interest

None declare.

Supplementary material

520_2012_1432_MOESM1_ESM.docx (24 kb)
ESM 1 (DOCX 24 kb)


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Tae-Young Choi
    • 1
  • Myeong Soo Lee
    • 1
  • Tae-Hun Kim
    • 1
  • Christopher Zaslawski
    • 3
  • Edzard Ernst
    • 2
  1. 1.Medical Research DivisionKorea Institute of Oriental MedicineDaejeonSouth Korea
  2. 2.Complementary Medicine, Peninsula Medical SchoolUniversity of ExeterExeterUK
  3. 3.College of Traditional Chinese MedicineUniversity of TechnologySydneyAustralia

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