Chemotherapy line-associated differences in quality of life in patients with advanced cancer
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The aim of this study was to investigate quality of life (QOL) differences between patients receiving first, second, or third-line palliative chemotherapy (CT).Furthermore, QOL was also compared to a sex- and age-matched sample of healthy controls.
Patients with different metastatic cancers receiving palliative CT were approached to complete the EORTC QLQ-C30 questionnaire by means of touch-screen computers before the start of CT, after 3 cycles and at the end of cytostatic treatment.
One hundred four patients were recruited for QOL assessment (56.9% of patients in first, 22.5% second and 20.6% third- or above-line palliative CT). Compared to healthy controls, they suffered from substantial QOL impairments in all EORTC QLQ-C30 sub-domains. In regard to CT lines, patients with first-line CT reached better scores in emotional and social functioning than second-line patients and less financial difficulties than third-line patients. Despite the high level of impairment in the patient sample, electronic data collection proved to be feasible and well accepted.
The results indicate that patients receiving third- or above-line palliative CT are confronted with stronger QOL impairments than first- and second-line patients. Supported by its feasibility and acceptance of by patients, electronic QOL data capture is an attractive method to screen for symptoms and track their course within clinical routine.
KeywordsPalliative cancer patients Patient-reported outcomes Quality of life Multiple chemotherapy lines
- 10.Albers P, Siener R, Hartlein M, Fallahi M, Haeutle D, Perabo FG, Steiner G, Blatter J, Muller SC (2002) Gemcitabine monotherapy as second-line treatment in cisplatin-refractory transitional cell carcinoma—prognostic factors for response and improvement of quality of life. Onkologie 25(1):47–52PubMedCrossRefGoogle Scholar
- 15.Giesinger J, Kemmler G, Mueller V, Zabernigg A, Mayrbaeurl B, Thaler J, Ofner D, Pegger C, Rumpold G, Weber B, Sperner-Unterweger B, Holzner B (2009) Are gender-associated differences in quality of life in colorectal cancer patients disease-specific? Qual Life Res 18(5):547–555PubMedCrossRefGoogle Scholar
- 16.Holzner B, Zabernigg A, Kemmler G, Baier S, Kopp M, Sperner Unterweger B (2004) Computerized assessment of quality of life in patients undergoing chemotherapy. Qual Life Res 13(9):1523Google Scholar
- 17.Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, Filiberti A, Flechtner H, Fleishman SB, de Haes JC (1993) The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85(5):365–376PubMedCrossRefGoogle Scholar
- 25.Bush N, Donaldson G, Moinpour C, Haberman M, Milliken D, Markle V, Lauson J (2005) Development, feasibility and compliance of a web-based system for very frequent QOL and symptom home self-assessment after hematopoietic stem cell transplantation. Qual Life Res 14(7):77–93PubMedCrossRefGoogle Scholar
- 28.Zagonel V, Fratino L, Piselli P, Milan I, La Conca G, Serraino D, Monfardini S (2002) The comprehensive geriatric assessment (CGA) predicts mortality among elderly cancer patients (ECP). Proc Am Soc Clin Oncol 21: 2002 (abstr 1458).Google Scholar