Supportive Care in Cancer

, Volume 19, Issue 9, pp 1471–1472 | Cite as

High doses of oxycodone–naloxone combination may provide poor analgesia

  • Sebastiano MercadanteEmail author
  • Patrizia Ferrera
  • Claudio Adile
Short Communication


Several studies have shown that an oxycodone/naloxone combination (ratio 2:1) provides analgesia and less constipation in non-cancer patients receiving relatively low doses of this formulation. A case report of a cancer patient who was receiving increasing doses of oxycodone with an unexpected declining analgesia is presented. The substitution with the same doses (240 mg/day) of regular controlled-release oxycodone was effective in regaining adequate analgesia.


Cancer pain Oxycodone Naloxone Constipation 


Conflict of interest

There are no conflicts of interest.


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Sebastiano Mercadante
    • 1
    • 2
    Email author
  • Patrizia Ferrera
    • 1
  • Claudio Adile
    • 1
  1. 1.Pain Relief and Palliative Care UnitLa Maddalena Cancer CenterPalermoItaly
  2. 2.Department of Anesthesia and Intensive CareUniversity of PalermoPalermoItaly

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