Supportive Care in Cancer

, Volume 20, Issue 4, pp 821–829 | Cite as

Impaired physiological function and health-related QOL in patients before hematopoietic stem-cell transplantation

  • Shinichiro Morishita
  • Katsuji Kaida
  • Kazuhiro Ikegame
  • Satoshi Yoshihara
  • Kyoko Taniguchi
  • Masaya Okada
  • Norihiko Kodama
  • Hiroyasu Ogawa
  • Kazuhisa Domen
Original Article



Patients' physiological functions and health-related quality of life (QOL) are useful for planning physical therapy after allogeneic hematopoietic stem-cell transplantation (allo-HSCT), but have not been extensively examined prior to transplantation. We investigated whether physiological functions and health-related QOL were reduced in patients before undergoing allo-HSCT.


All patients (n = 110) who underwent allo-HSCT between May 2007 and April 2010 at Hyogo College of Medicine Hospital were included in this study and evaluated for hand-grip and knee-extensor strength; 6-min walk test (6MWT) and health-related QOL (SF-36) were also used for evaluation.


Grip strength, knee-extensor strength, 6MWT, and all eight SF-36 health-related QOL subscale scores significantly decreased in HSCT patients compared to population norms (all, P < 0.01). Health-related QOL is associated with various confounding factors such as fatigue and sex. Loss of physiological function is also associated with confounding factors; one such association was found between skeletal muscle strength and previous HSCT treatment.


Health-related QOL and loss of physiological function have a variety confounding factors. Patients scheduled for HSCT may have physiological weaknesses prior to transplant, which need to be considered when planning an exercise regimen during and after transplantation.


Hematopoietic stem-cell transplantation Muscle strength 6-min walk test Quality of life 



The authors are grateful to the study participants, the physiotherapists at the Rehabilitation Department, and the physicians at the Division of Hematology in Hyogo College of Medicine Hospital.

Conflict of interest

The authors declare no conflict of interest.


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Shinichiro Morishita
    • 1
  • Katsuji Kaida
    • 2
  • Kazuhiro Ikegame
    • 2
  • Satoshi Yoshihara
    • 2
  • Kyoko Taniguchi
    • 2
  • Masaya Okada
    • 2
  • Norihiko Kodama
    • 3
  • Hiroyasu Ogawa
    • 2
  • Kazuhisa Domen
    • 3
  1. 1.Department of RehabilitationHyogo College of Medicine HospitalNishinomiyaJapan
  2. 2.Division of Hematology, Department of Internal MedicineHyogo College of MedicineNishinomiyaJapan
  3. 3.Department of Rehabilitation MedicineHyogo College of MedicineNishinomiyaJapan

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