Supportive Care in Cancer

, Volume 20, Issue 2, pp 367–373 | Cite as

Professional oral health care reduces oral mucositis and febrile neutropenia in patients treated with allogeneic bone marrow transplantation

  • Haruhiko Kashiwazaki
  • Takae Matsushita
  • Junichi Sugita
  • Akio Shigematsu
  • Kumiko Kasashi
  • Yutaka Yamazaki
  • Takashi Kanehira
  • Satoshi Yamamoto
  • Takeshi Kondo
  • Tomoyuki Endo
  • Junji Tanaka
  • Satoshi Hashino
  • Mitsufumi Nishio
  • Masahiro Imamura
  • Yoshimasa Kitagawa
  • Nobuo Inoue
Original Article

Abstract

Goal of work

Little is known about the effects of professional oral health care (POHC) on the outcome of hematopoietic stem cell transplantation (HSCT). We evaluated the effects of POHC given by dentists and dental hygienists on the development of oral mucositis and febrile neutropenia (FN) after allogeneic bone marrow transplantation (BMT).

Patients and methods

We retrospectively studied 140 adult patients who had received allogeneic BMT, with or without POHC, in our hospital consecutively between February 2002 and December 2009. Oral mucositis was evaluated according to the World Health Organization scale.

Main results

The incidence of oral mucositis was 66.7% (52/78) in the patients who had received POHC, compared to 93.5% (58/62) in the non-POHC group (P < 0.001). The incidence of FN and the maximal level of CRP were also significantly lower in the POHC group. Multivariate analysis revealed that the POHC was significantly associated with the incidence of oral mucositis (odds ratio, 7.58; 95%CI, 2.45–23.34; P < 0.001).

Conclusions

We concluded that POHC reduced the incidences of oral mucositis and FN by upgrading the overall oral hygiene during HSCT.

Keywords

Professional oral health care Oral mucositis Bone marrow transplantation Multivariate analysis Quality of life 

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Haruhiko Kashiwazaki
    • 1
  • Takae Matsushita
    • 1
  • Junichi Sugita
    • 2
  • Akio Shigematsu
    • 2
  • Kumiko Kasashi
    • 3
  • Yutaka Yamazaki
    • 4
  • Takashi Kanehira
    • 5
  • Satoshi Yamamoto
    • 2
  • Takeshi Kondo
    • 2
  • Tomoyuki Endo
    • 2
  • Junji Tanaka
    • 2
  • Satoshi Hashino
    • 2
  • Mitsufumi Nishio
    • 2
  • Masahiro Imamura
    • 2
  • Yoshimasa Kitagawa
    • 4
  • Nobuo Inoue
    • 1
  1. 1.Gerodontology, Division of Oral Health ScienceHokkaido University Graduate School of Dental MedicineSapporoJapan
  2. 2.Stem Cell Transplantation CenterHokkaido University HospitalSapporoJapan
  3. 3.Division of PharmacyHokkaido University HospitalSapporoJapan
  4. 4.Oral Diagnosis and Oral Medicine, Division of Oral Pathobiological ScienceHokkaido University Graduate School of Dental MedicineSapporoJapan
  5. 5.Preventive Dentistry, Division of Oral Health ScienceHokkaido University Graduate School of Dental MedicineSapporoJapan

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