Supportive Care in Cancer

, Volume 19, Issue 6, pp 859–863 | Cite as

A pilot phase II trial of magnesium supplements to reduce menopausal hot flashes in breast cancer patients

  • Haeseong Park
  • Gwendolyn L. Parker
  • Cecelia H. Boardman
  • Monica M. Morris
  • Thomas J. Smith
Short Communication

Abstract

Background

We tested if magnesium would diminish bothersome hot flashes in breast cancer patients.

Methods

Breast cancer patients with at least 14 hot flashes a week received magnesium oxide 400 mg for 4 weeks, escalating to 800 mg if needed. Hot flash score (frequency × severity) at baseline was compared to the end of treatment.

Results

Of 29 who enrolled, 25 women completed treatment. The average age was 53.5 years; six African American, the rest Caucasian; eight were on tamoxifen, nine were on aromatase inhibitors, and 14 were on anti-depressants. Seventeen patients escalated the magnesium dose. Hot flash frequency/week was reduced from 52.2 (standard error (SE), 13.7) to 27.7 (SE, 5.7), a 41.4% reduction, p = 0.02, two-sided paired t test. Hot flash score was reduced from 109.8 (SE, 40.9) to 47.8 (SE, 13.8), a 50.4% reduction, p = 0.04. Of 25 patients, 14 (56%) had a >50% reduction in hot flash score, and 19 (76%) had a >25% reduction. Fatigue, sweating, and distress were all significantly reduced. Side effects were minor: two women stopped the drug including one each with headache and nausea, and two women had grade 1 diarrhea. Compliance was excellent, and many patients continued treatment after the trial.

Conclusions

Oral magnesium appears to have helped more than half of the patients and was well tolerated. Side effects and cost ($0.02/tablet) were minimal. A randomized placebo-controlled trial is planned.

Keywords

Menopause Hot flashes Breast cancer Survivorship Drug treatment 

References

  1. 1.
    Feldman BM, Voda A, Gronseth E (1985) The prevalence of hot flash and associated variables among perimenopausal women. Res Nurs Health 8:261–268PubMedCrossRefGoogle Scholar
  2. 2.
    Carpenter JS, Andrykowski MA (1999) Menopausal symptoms in breast cancer survivors. Oncol Nurs Forum 26:1311–1317PubMedGoogle Scholar
  3. 3.
    Loprinzi CL, Wolf SL, Barton DL et al (2008) Symptom management in premenopausal patients with breast cancer. Lancet Oncol 9:993–1001PubMedCrossRefGoogle Scholar
  4. 4.
    Bordeleau L, Pritchard K, Goodwin P et al (2007) Therapeutic options for the management of hot flashes in breast cancer survivors: an evidence-based review. Clin Ther 29:230–241PubMedCrossRefGoogle Scholar
  5. 5.
    Quella SK, Loprinzi CL, Sloan JA et al (1998) Long term use of megestrol acetate by cancer survivors for the treatment of hot flashes. Cancer 82:1784–1788PubMedCrossRefGoogle Scholar
  6. 6.
    Loprinzi CL, Levitt R, Barton D et al (2006) Phase III comparison of depomedroxyprogesterone acetate to venlafaxine for managing hot flashes: North Central Cancer Treatment Group Trial N99C7. J Clin Oncol 24:1409–1414PubMedCrossRefGoogle Scholar
  7. 7.
    Smith TJ (2009) Magnesium supplements for menopausal hot flashes. J Clin Oncol 27:1151–1152PubMedCrossRefGoogle Scholar
  8. 8.
    Houston MC, Harper KJ (2008) Potassium, magnesium, and calcium: their role in both the cause and treatment of hypertension. J Clin Hypertens (Greenwich) 10:3–11CrossRefGoogle Scholar
  9. 9.
    Sibai BM (2003) Diagnosis and management of gestational hypertension and preeclampsia. Obstet Gynecol 102:181–192PubMedCrossRefGoogle Scholar
  10. 10.
    Gums JG (2004) Magnesium in cardiovascular and other disorders. Am J Health-Syst Pharm 61:1569–1576PubMedGoogle Scholar
  11. 11.
    Nechifor M (2009) Magnesium in major depression. Magnes Res 22:163S–166SPubMedGoogle Scholar
  12. 12.
    Sloan JA, Loprinzi CL, Novotny PJ et al (2001) Methodologic lessons learned from hot flash studies. J Clin Oncol 19:4280–4290PubMedGoogle Scholar
  13. 13.
    Mago R, Mahajan R, Thase ME (2008) Medically serious adverse effects of newer antidepressants. Curr Psychiatry Rep 10:249–257PubMedCrossRefGoogle Scholar
  14. 14.
    Moret C, Isaac M, Briley M (2009) Problems associated with long-term treatment with selective serotonin reuptake inhibitors. J Psychopharmacol 23:967–974PubMedCrossRefGoogle Scholar
  15. 15.
    Nechifor M (2008) Interactions between magnesium and psychotropic drugs. Magnes Res 21:97–100PubMedGoogle Scholar
  16. 16.
    Shanafelt TD, Barton DL, Adjei AA et al (2002) Pathophysiology and treatment of hot flashes. Mayo Clin Proc 77:1207–1218PubMedCrossRefGoogle Scholar
  17. 17.
    Kazaks AG, Uriu-Adams JY, Albertson TE et al (2010) Effect of oral magnesium supplementation on measures of airway resistance and subjective assessment of asthma control and quality of life in men and women with mild to moderate asthma: a randomized placebo controlled trial. J Asthma 47:83–92PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Haeseong Park
    • 1
  • Gwendolyn L. Parker
    • 2
  • Cecelia H. Boardman
    • 3
  • Monica M. Morris
    • 4
  • Thomas J. Smith
    • 2
    • 5
  1. 1.Department of Internal Medicine Residency ProgramVirginia Commonwealth University Health SystemRichmondUSA
  2. 2.Massey Cancer Center Cancer Prevention and Control ProgramVirginia Commonwealth University Health SystemRichmondUSA
  3. 3.Department of Obstetrics and GynecologyVirginia Commonwealth University Health SystemRichmondUSA
  4. 4.Department of Radiation OncologyUniversity of Virginia Radiation OncologyCharlottesvilleUSA
  5. 5.Palliative Care Research and Medicine, Division of Hematology/Oncology and Palliative CareThomas Palliative Care UnitRichmondUSA

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