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Supportive Care in Cancer

, Volume 19, Issue 2, pp 231–237 | Cite as

Incidence of vancomycin-resistant enterococci (VRE) infection in high-risk febrile neutropenic patients colonized with VRE

  • John B. Bossaer
  • Philip D. HallEmail author
  • Elizabeth Garrett-Mayer
Original Article

Abstract

Purpose

This study seeks to determine the incidence of vancomycin-resistant enterococci (VRE) infection in high-risk neutropenic fever patients colonized with VRE and to determine patient characteristics associated with VRE infection.

Methods

We conducted a retrospective, single-center, unmatched case-control study. Fifty-three VRE-colonized, high-risk patients with neutropenic fever were identified between January 2006 and February 2009. The two most common diagnoses/conditions included acute myeloid leukemia and hematopoietic stem cell transplantation. Data collected included days of neutropenia, days of fever, demographic data, culture results, and antimicrobial therapy.

Results

Twenty of the 53 patients (38%) with VRE colonization developed a VRE infection. The most common VRE infections were bacteremias (26%). The presence of neutropenia lasting longer than 7 days was associated with the development of VRE infection in this high-risk population colonized with VRE. The timeframe to develop VRE infection varied from 1 day to 2 weeks.

Conclusion

For patients colonized with VRE, approximately 38% of high-risk neutropenic patients developed a VRE infection. This is the first study to specifically evaluate the incidence of VRE infections in febrile neutropenic patients colonized with VRE. Future research into the use and efficacy of empiric VRE coverage is needed.

Keywords

Vancomycin-resistant enterococci (VRE) Febrile neutropenia Daptomycin Linezolid 

Abbreviations

FN

febrile neutropenia

VRE

vancomycin-resistant enterococci

HSCT

hematopoietic stem cell transplantation

BSI

blood stream infection

ANC

absolute neutrophil count

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • John B. Bossaer
    • 1
  • Philip D. Hall
    • 2
    • 4
    Email author
  • Elizabeth Garrett-Mayer
    • 3
  1. 1.Department of Pharmacy Practice, Bill Gatton College of PharmacyEast Tennessee State UniversityJohnson CityUSA
  2. 2.Department of Clinical Pharmacy and Outcomes Sciences, South Carolina College of PharmacyMedical University of South CarolinaCharlestonUSA
  3. 3.Hollings Cancer CenterMedical University of South CarolinaCharlestonUSA
  4. 4.South Carolina College of Pharmacy274 Calhoun Street, MSC 141CharlestonUSA

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