Supportive Care in Cancer

, Volume 18, Issue 4, pp 481–490 | Cite as

Validation of the Portuguese version of Functional Assessment of Cancer Therapy-Fatigue (FACT-F) in Brazilian cancer patients

  • Neli Muraki Ishikawa
  • Luiz Claudio Santos Thuler
  • Alessandra Grasso Giglio
  • Clarissa Seródio da Rocha Baldotto
  • Carlos José Coelho de Andrade
  • Sophie Françoise Mauricette Derchain
Original Article


Goals of work

The purpose of this study was to validate the Portuguese version of the Functional Assessment of Cancer Therapy-Fatigue (FACT-F) in order to establish its assessment properties, including validity and reliability in a sample of Brazilian cancer patients.

Materials and methods

Two hundred seventy patients with different types of cancer were included for this study; the mean age was 50.5 years. The reliability was assessed by internal consistency and reproducibility. Construct validity was assessed through convergent validity and discriminant validity. Convergent validity was examined by comparing the FACT-F to the SF-36. Discriminant validity of the FACT-F evaluated the ability of the scale to differentiate defined groups, discriminating patients according to Eastern Cooperative Oncology Group Performance Status and different stages of disease.

Main results

FACT-F had high internal consistency (Cronbach α coefficient was 0.78 for physical well-being, 0.68 for social/family well-being, 0.75 for emotional well-being, 0.74 for functional well-being, 0.91 for fatigue, and 0.92 for total FACT-F). The range of test–retest intraclass correlation was from 0.72 to 0.91 (p < 0.0001). The Pearson product correlation revealed good correlations between the total FACT-F and subscales of the SF-36 in most dimensions, ranging from r = 0.51 to r = 0.76, except for SF-36 physical (r = 0.31). The positive correlations between the SF-36 vitality scale and FACT-F total (r = 0.76) and the fatigue subscale (r = 0.77) support the convergent validity.


The Portuguese version of FACT-F is a reliable and valid instrument to assess quality of life and fatigue, representing a valid tool to screen cancer-related fatigue in Brazilian cancer patients.


Fatigue Quality of life FACT-F Questionnaire Cancer 



The authors are grateful to Mr. Ben Arnold and Ms. Helen Morrow for permission to use the instrument FACT-F in this study and for having provided the questionnaire in Portuguese language. We also thank Mrs. Sirlei Siani Morais for help in statistical review. Finally, we are grateful to all patients who participated in the study.

Authors’ disclosures of potential conflicts of interest

Authors wish to disclose the absence of financial support and indicated no potential conflicts of interest.


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Neli Muraki Ishikawa
    • 1
  • Luiz Claudio Santos Thuler
    • 2
  • Alessandra Grasso Giglio
    • 3
  • Clarissa Seródio da Rocha Baldotto
    • 4
  • Carlos José Coelho de Andrade
    • 4
  • Sophie Françoise Mauricette Derchain
    • 5
  1. 1.Physical Therapy DepartmentBrazilian National Cancer Institute-INCACentro-Rio de JaneiroBrazil
  2. 2.Federal University of the State of Rio de Janeiro-UNIRIOMaracanã-Rio de JaneiroBrazil
  3. 3.Hospital of Cancer IIBrazilian National Cancer Institute-INCASanto Cristo-Rio de JaneiroBrazil
  4. 4.Clinical Oncology DepartmentBrazilian National Cancer Institute-INCACentro-Rio de JaneiroBrazil
  5. 5.Department of Obstetrics and GynecologyCampinas State UniversityCampinasBrazil

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