Use of oxygen and opioids in the palliation of dyspnoea in hypoxic and non-hypoxic palliative care patients: a prospective study

  • Katri Elina ClemensEmail author
  • Ines Quednau
  • Eberhard Klaschik
Original Article



Dyspnoea is a complex experience of the body and the mind. Whereas the effects of opioids on dyspnoea in advanced disease have been the focus of studies for management of dyspnoea in palliative medicine, the role of oxygen is still unclear. The effects of symptomatic oxygen and opioid treatment on ventilation and palliation of dyspnoea in hypoxic (H) and non-hypoxic (NH) palliative care patients were assessed and compared.


In a prospective, non-randomised study, 46 patients with mild to severe dyspnoea were included. Transcutaneous measurement (earlobe sensor) of carbon dioxide partial pressure (tcpaCO2), pulse oximetry oxygen saturation (SaO2) and pulse frequency (PF) were monitored with SenTec digital monitor. Compared was: baseline data of the continuously documented respiratory parameters for about 15 min in patients breathing room air at admission, 60 min during nasal O2 insufflation, and 30, 90 and 120 min after the first opioid application and without O2 insufflation.


Whereas opioid application resulted in a significant decrease in the intensity of dyspnoea and respiratory rate, during the nasal O2 insufflation (4 l/min), there was no significant decrease in the intensity of dyspnoea neither in H (P = 0.564) nor in NH (P = 0.096) patients. There was no evidence of a significant correlation between the intensity of dyspnoea and oxygen saturation. The Spearman rank correlation in NH patients was −0.080 (P = 0.686) and in H patients P = 0.296 (P = 0.233). No significant differences between the groups of hypoxic and non-hypoxic patients with regard to tcpaCO2 increase (P = 0.075 NH; P = 0.346 H) or SaO2 decrease after opioid application (P = 0.077) were found.


In this study, opioids worked significantly better than oxygen in reducing the intensity of dyspnoea even in hypoxic patients. There was no correlation between intensity of dyspnoea and oxygen saturation in H and NH patients. Oxygen should be seen as a pharmacological agent and not be given based on intuitive assumption of benefit.


Hypoxaemia Hypercapnia Respiratory depression Opioids Oxygen saturation Transcutaneous capnometry Dyspnoea 



The authors would like to thank Birgit Jaspers for careful review of this manuscript and English editing.

This study is sponsored by Deutsche Krebshilfe e.V. (German Cancer Aid). The sponsor had no impact on the investigator-initiated work of the authors.


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Katri Elina Clemens
    • 1
    • 2
    • 3
    Email author
  • Ines Quednau
    • 1
  • Eberhard Klaschik
    • 1
    • 2
  1. 1.Department of Science and Research, Centre for Palliative MedicineUniversity of BonnBonnGermany
  2. 2.Department of Anaesthesiology, Intensive Care Medicine, Palliative Medicine and Pain TherapyMalteser Hospital Bonn/Rhein-SiegBonnGermany
  3. 3.Department of Science and Research in Palliative Medicine, Centre for Palliative MedicineUniversity of Bonn, Malteser Hospital Bonn/Rhein-SiegBonnGermany

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