Supportive Care in Cancer

, Volume 16, Issue 3, pp 229–234

Biomarkers for cancer cachexia: is there also a genetic component to cachexia?

  • B. H. L. Tan
  • D. A. C. Deans
  • R. J. E. Skipworth
  • J. A. Ross
  • K. C. H. Fearon
Review Article

DOI: 10.1007/s00520-007-0367-z

Cite this article as:
Tan, B.H.L., Deans, D.A.C., Skipworth, R.J.E. et al. Support Care Cancer (2008) 16: 229. doi:10.1007/s00520-007-0367-z

Abstract

Introduction

Cancer cachexia is a severe debilitating disorder, which causes significant morbidity and mortality. In clinical practice, cachexia is often not treated until a late stage, when therapeutic options are limited.

Objective

It is therefore of great interest to analyse early biomarkers of this syndrome.

Conclusion

In this review article, we summarise recent biomarkers found in various body compartments. We also explore the likelihood of a genetic predisposition to cachexia and focus on the potential role of single nucleotide polymorphisms in genes coding for pro- and anti-inflammatory cytokines, and ‘atrogenes’ associated with wasting in skeletal muscle.

Keywords

Cachexia Cancer Biomarkers Genetics Polymorphisms 

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • B. H. L. Tan
    • 1
  • D. A. C. Deans
    • 1
  • R. J. E. Skipworth
    • 1
  • J. A. Ross
    • 1
  • K. C. H. Fearon
    • 1
  1. 1.Clinical and Surgical Sciences (Surgery), School of Clinical Sciences and Community HealthThe University of EdinburghEdinburghUK

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