Supportive Care in Cancer

, Volume 14, Issue 6, pp 558–565 | Cite as

Anti-inflammatory agents in the management of alimentary mucositis

  • Rajesh V. LallaEmail author
  • Mark M. Schubert
  • Rene-Jean Bensadoun
  • Dorothy Keefe
Review Article



Alimentary mucositis is a significant complication of cancer therapy, with important clinical and economic implications.

Materials and methods

In June 2005, the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology conducted an evidence-based review of the literature on alimentary mucositis. The goal of this literature review was to update previously published guidelines for the management of mucositis.


This article reports the findings of the subgroup charged with reviewing the literature related to anti-inflammatory interventions. Considerable preclinical and clinical evidence suggests that the use of anti-inflammatory agents may be a promising approach to reduce the severity of mucositis. However, there was not enough evidence to support any new guidelines advocating the use of any specific anti-inflammatory intervention.


Thus, there is a need for well-designed clinical trials evaluating the use of anti-inflammatory agents in the management of mucositis.


Allopurinol Misoprostol Mesalazine Oral Mucositis Neck Cancer Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors thank Mr. Ronald D. Hutchins, University of Texas MD Anderson Cancer Center, for conducting the literature search.


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Rajesh V. Lalla
    • 1
    Email author
  • Mark M. Schubert
    • 2
    • 3
  • Rene-Jean Bensadoun
    • 4
  • Dorothy Keefe
    • 5
  1. 1.Department of Oral Health and Diagnostic Sciences MC1605University of Connecticut Health CenterFarmingtonUSA
  2. 2.Department of Oral MedicineUniversity of WashingtonSeattleUSA
  3. 3.Oral MedicineSeattle Cancer Care AllianceSeattleUSA
  4. 4.Department of Radiation OncologyCentre Antoine-LacassagneNiceFrance
  5. 5.Department of MedicineUniversity of AdelaideAdelaideSouth Australia

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