The role of alternative and natural agents, cryotherapy, and/or laser for management of alimentary mucositis
- 714 Downloads
Goals of work
To review the literature and update the current guidelines of alternative/natural agents, cryotherapy, and/or laser therapy in the management of alimentary mucositis (AM).
Materials and methods
The original guidelines developed by the Multinational Association for Supportive Care in Cancer (MASCC)/International Society for Oral Oncology (ISOO) mucositis study group were the basis for this study. A medical librarian conducted an initial Medline search to identify research articles published between 2002 and 2005 in English language. A search term combination that included stomatitis, mucositis, mucous membrane, neoplasm, lasers, complimentary therapies, amino acids, antioxidants, vitamins, minerals, plant extracts, and cryotherapy was conducted. This initial search identified articles with a strong scientific methodology that included both preclinical and clinical research. Using standardized scoring forms, authors reviewed and scored individual articles. A consensus result of the review was achieved in a meeting of reviewers in June of 2005.
The initial search identified a total of 167 new articles. Of these, 14 were selected and reviewed: alternative/natural therapy (one preclinical study); cryotherapy (four clinical studies); lasers (two clinical studies); and alternative/natural agents (seven clinical studies). A new guideline could be established for the use of cryotherapy in the management of AM in hematopoietic stem cell transplant (HSCT) patients receiving melphalan in the conditioning phase.
The rapid progress in the understanding of AM created a need for new prevention and management protocols. Frequent literature review is now necessary to identify agents and protocols being developed in this important area of supportive care in cancer.
KeywordsStomatitis Mucositis Cryotherapy Laser Natural agents
- 6.Bensadoun RJ, Ciais G, Darcourt V, Schhubert MM, Viot M, Dejou J, Tardieu C, Benezery K, Nguyen TD, Landoyer Y, Dassonville O, Poissonnet G, Vallicioni J, Thyss A, Hamdi M, Chauvel P, Demand F (1999) Low-energy H/Ne laser in the prevention of radiation-induced mucositis. A multicenter phase III randomized study in patients with head and neck cancer. Support Care Cancer 7:244–252CrossRefPubMedGoogle Scholar
- 8.Cascinu S, Fedeli A, Fedeli SL, Catalano G (1994) Oral cooling (cryotherapy, an effective treatment for the prevention of 5-fluorouracil-induced stomatitis. Eur J Cancer Part B Oral Oncol 9:449–452Google Scholar
- 16.Mahood DJ, Dose AM, Loprinzi CL, Veeder MH, Athman LM, Therneau TM, Sorensen JM, Gainey DK, Maillard JA, Gusa NL (1991) Inhibition of fluorouracil-induced stomatitis by oral cryotherapy. JCO 9:449452Google Scholar
- 20.Piccirillo N, De Matteis S, Laurenti L, Chiusolo P, Sora F, Pittiruti M, Rutella S, Cicconi S, Fiorini A, D’Onofrio G, Leone G, Sica A (2003) Glutamine-enriched parenteral nutrition after autologous peripheral blood stem cell transplantation: effects on immune reconstitution and mucositis. Haematologica 88:192–200PubMedGoogle Scholar
- 21.Prince HM, Regester G, Gates P, Jablosnkis L, Seymour JF, Lillie K, West R, Wolf M, Januszewicz H, Belford D (2005) A phase Ib clinical trial of PV701, a milk-derived protein extract, for the prevention and treatment of oral mucositis in patients undergoing high-dose BEAM chemotherapy. Biol Blood Marrow Transplant 11:512–520CrossRefPubMedGoogle Scholar
- 25.Somerfield MR, Padberg JJ, Pfister DG, Bennett CL, Recht A, Smith TJ, Weeks JC, Winn RJ, Durant JR (2000) ASCO clinical practice guidelines: process, progress, pitfalls, and prospects. Classic Papers Current Comments 4:881–886Google Scholar
- 27.Su CK, Mehta V, Ravikumar L, Shah R, Pinto H, Halpern J, Koong A, Goffinet D, Le Q-T (2004) Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms. Int J Radiat Oncol Biol Phys 60:171–177CrossRefPubMedGoogle Scholar