Supportive Care in Cancer

, Volume 13, Issue 7, pp 554–558 | Cite as

The comparative effects of povidone-iodine and normal saline mouthwashes on oral mucositis in patients after high-dose chemotherapy and APBSCT—results of a randomized multicentre study

  • Samuel VokurkaEmail author
  • Eva Bystřická
  • Vladimír Koza
  • Jana Sčudlová
  • Vladislava Pavlicová
  • Dana Valentová
  • Jana Bocková
  • Lubica Mišaniová
Short Communication


Antimicrobial solutions are widely used in the nursing care of chemotherapy induced oral mucositis (OM). There is little evidence, however, supporting their use for reducing mucosal damage. In our study, 132 patients were randomized to use normal saline (n=65) or povidone-iodine diluted 1:100 (n=67) mouthwashes for OM prophylaxis and treatment after high-dose chemotherapy comprising BEAM or HD-L-PAM followed by autologous peripheral stem cell transplantation. The study groups were well balanced in respect of age, sex, chemotherapy and the number of CD34+ cells in the graft. No significant difference was found between the groups in respect of OM characteristics, fever of unknown origin (FUO) and other infections. The antimicrobial solution was less tolerable for patients. OM occurred significantly more often in females than in males (86% vs 60%, P=0.0016) and was worse and of longer duration. The mechanical effect of mouthwashes might have a certain importance in FUO prevention. When indicating oral rinses, the patient’s individual preference and tolerance of solutions offered should be considered.


Oral mucositis Povidone-iodine Mouthwashes Antimicrobial rinses Autologous transplantation Nursing 



We acknowledge the assistance of K. Steinerova MD, I. Chvojková, V. Kaslová (Plzeň), J. Vítková (Olomouc), J. Maslová (Hradec Králové), P. Horvathová, V. Jarolíková, R. Micheličová (Bratislava), M. Visokaiová (Košice), A. Kalocayová, E. Karliková, S. Kerestenyová, S. Gyurkyová, and S. Staštianová (Bánská Bystrica).


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Samuel Vokurka
    • 1
    Email author
  • Eva Bystřická
    • 1
  • Vladimír Koza
    • 1
  • Jana Sčudlová
    • 2
  • Vladislava Pavlicová
    • 3
  • Dana Valentová
    • 4
  • Jana Bocková
    • 5
  • Lubica Mišaniová
    • 6
  1. 1.Department of Haemato-OncologyUniversity HospitalPilsenCzech Republic
  2. 2.Department of Haemato-OncologyUniversity Hospital OlomoucOlomoucCzech Republic
  3. 3.Department of Clinical HaematologyUniversity HospitalHradec KraloveCzech Republic
  4. 4.Department of Haematology and Transfusion MedicineUniversity HospitalBratislavaSlovak Republic
  5. 5.Department of HaematologyUniversity HospitalKosiceSlovak Republic
  6. 6.Department of HaematologyF.D.Roosevelt HospitalBanska BystricaSlovak Republic

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