Gabapentin in the treatment of severe sweating experienced by advanced cancer patients

  • Giampiero Porzio
  • Federica Aielli
  • Lucilla Verna
  • Claudio Porto
  • Paolo Aloisi
  • Katia Cannita
  • Enrico Ricevuto
  • Paolo Marchetti
  • Corrado Ficorella
Short Communication

Abstract

Nine patients with advanced cancer suffering from idiopathic severe sweating were treated with gabapentin (600–1,800 mg/day). All patients responded to the treatment; five patients experienced transient drowsiness. Gabapentin seems to be a safe and effective treatment for idiopathic sweating in advanced cancer patients. Further studies are warranted to confirm or refute these results.

Keywords

Sweating Gabapentin 

References

  1. 1.
    Adelson KB, Loprinzi CL, Hershman DL (2005) Treatment of hot flushes in breast and prostate cancer. Expert Opin Pharmacother 6:1095–1106PubMedCrossRefGoogle Scholar
  2. 2.
    Albertazzi P, Bottazzi M, Purdie DW (2003) Gabapentin for the management of hot flushes: a case series. Menopause 10:214–217PubMedCrossRefGoogle Scholar
  3. 3.
    Cobleigh MA, Berris RF, Bush T et al (1994) Estrogen replacement therapy in breast cancer survivors. A time to change. JAMA 272:540–545PubMedCrossRefGoogle Scholar
  4. 4.
    Cowap J, Hardy J (1998) Thioridazine in the management of cancer-related sweating. J Pain Symptom Manage 15:266PubMedGoogle Scholar
  5. 5.
    Deaner PB (2000) The use of thalidomide in the management of severe sweating in patients with advanced malignancy: trial report. Palliat Med 14:429–431PubMedCrossRefGoogle Scholar
  6. 6.
    Guttuso T Jr (2004) Hot flashes refractory to HRT and SSRI therapy but responsive to Gabapentin therapy. J Pain Symptom Manage 27:274–276PubMedCrossRefGoogle Scholar
  7. 7.
    Guttuso T Jr, Kurlan R, McDermott MP et al (2003) Gabapentin’s effects on hot flashes in postmenopausal women: a randomised controlled trial. Obstet Gynecol 101:337–345PubMedCrossRefGoogle Scholar
  8. 8.
    Jeffery SM, Pepe JJ, Popovich LM, Vitigliano G (2002) Gabapentin for hot flashes in prostate cancer. Ann Pharmacother 36:433–436PubMedCrossRefGoogle Scholar
  9. 9.
    Loprinzi CL, Michalak JC, Quella SK et al (1994) Megestrol acetate for the prevention of hot flushes. N Engl J Med 331:347–352PubMedCrossRefGoogle Scholar
  10. 10.
    Mellegers MA, Furlan AD, Mailis A (2001) Gabapentin for neuropathic pain: systematic review of controlled and uncontrolled literature. Clin J Pain 17:284–295PubMedCrossRefGoogle Scholar
  11. 11.
    Mercadante S (1998) Hyoscine in opioid-induced sweating. J Pain Symptom Manage 15:214–215PubMedCrossRefGoogle Scholar
  12. 12.
    Pandya KJ, Morrow GR, Roscoe JA et al (2005) Gabapentin in hot flashes in 420 women with breast cancer: a randomised double-blind placebo-controlled trial. Lancet 366:818–824PubMedCrossRefGoogle Scholar
  13. 13.
    Quigley CS, Baines M (1997) Descriptive epidemiology of sweating in a hospice population. J Palliat Care 13:22–26PubMedGoogle Scholar
  14. 14.
    Tsavaris N, Zinelis A, Karabelis A et al (1990) A randomized trial of the effect of three non-steroidal anti-inflammatory agents in ameliorating cancer-induced fever. J Intern Med 228:451–455PubMedCrossRefGoogle Scholar
  15. 15.
    Zhucovsky DS (2002) Fever and sweats in the patient with advanced cancer. Hematol Oncol Clin North Am 16:579–588CrossRefGoogle Scholar
  16. 16.
    Zylicz Z, Krajnik M (2003) Flushing and sweating in an advanced breast cancer patient relieved by olanzapine. J Pain Symptom Manage 25:494–495PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Giampiero Porzio
    • 1
    • 4
  • Federica Aielli
    • 1
  • Lucilla Verna
    • 1
  • Claudio Porto
    • 2
  • Paolo Aloisi
    • 2
  • Katia Cannita
    • 3
  • Enrico Ricevuto
    • 3
  • Paolo Marchetti
    • 3
  • Corrado Ficorella
    • 3
  1. 1.Supportive Care Task Force, Medical Oncology DepartmentUniversity of L’AquilaL’AquilaItaly
  2. 2.Neurophisiopatology Unit, San Salvatore HospitalL’AquilaItaly
  3. 3.Medical Oncology DepartmentUniversity of L’AquilaL’AquilaItaly
  4. 4.Dipartimento di Medicina SperimentaleUniversità degli StudiL’AquilaItaly

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