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Supportive Care in Cancer

, Volume 13, Issue 9, pp 671–678 | Cite as

Granisetron in the control of radiotherapy-induced nausea and vomiting: a comparison with other antiemetic therapies

  • Petra FeyerEmail author
  • M. Heinrich Seegenschmiedt
  • Maria Steingraeber
Review Article

Abstract

Radiotherapy-induced nausea and vomiting (RINV) can be one of the most distressing symptoms of radiotherapy treatment, which if incompletely controlled may last for several weeks with fractionated radiotherapy and prevent completion of the planned treatment course. Current treatment guidelines recommend the use of 5-HT3 receptor antagonists with or without corticosteroids for highly and moderately emetogenic radiotherapy, though only granisetron and ondansetron are currently indicated for RINV in most countries. Granisetron is a potent and highly selective 5-HT3 receptor antagonist, with demonstrated efficacy in RINV in both placebo-controlled and comparative studies. In this paper the clinical experience with granisetron in RINV is reviewed, and its efficacy and safety compared with other antiemetic therapies.

Keywords

Nausea and vomiting Radiotherapy Antiemetic 5-HT3 receptor antagonist Granisetron 

Notes

Acknowledgements

This paper was supported by Hoffmann-La Roche.

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Petra Feyer
    • 1
    Email author
  • M. Heinrich Seegenschmiedt
    • 2
  • Maria Steingraeber
    • 1
  1. 1.Clinic of Radiooncology and Nuclear MedicineVivantes Clinics NeukoellnBerlinGermany
  2. 2.Clinic of RadiooncologyAlfried Krupp HospitalEssenGermany

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