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Supportive Care in Cancer

, Volume 13, Issue 3, pp 138–144 | Cite as

Advances in opioid therapy and formulations

  • Declan WalshEmail author
Review Article

Abstract

Newly developed opioid analgesics and drug delivery systems may provide pain relief for patients intolerant of morphine. Long-acting oral opioids supply satisfactory analgesia at more convenient dosing intervals. Implantable pumps can provide full analgesic doses of opioids both subcutaneously and intrathecally over extended time periods. Optimal opioid use should rely on individualized dose-finding approaches to enhance pain relief while limiting drug-related side effects and avoiding the common problems associated with opioid prescription in clinical practice.

Keywords

Opioids Formulations Drug delivery systems Dosing strategies 

Notes

Acknowledgment

This manuscript was supported by Endo Pharmaceuticals, Chadds Ford, PA, USA, with editorial assistance provided by Accel Medical Education, New York, NY, USA.

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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  1. 1.The Harry R. Horvitz Center for Palliative MedicineThe Cleveland Clinic Taussig Cancer CenterClevelandUSA
  2. 2.The Cleveland Clinic FoundationClevelandUSA

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