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Supportive Care in Cancer

, Volume 13, Issue 4, pp 246–254 | Cite as

Comparison of proposed diagnostic criteria with FACT-F and VAS for cancer-related fatigue: proposal for use as a screening tool

  • Simon Van BelleEmail author
  • Robert Paridaens
  • Georges Evers
  • Joseph Kerger
  • Dominique Bron
  • Jan Foubert
  • Gerrit Ponnet
  • Didier Vander Steichel
  • Christine Heremans
  • Dominique Rosillon
Original Article

Abstract

The objective was to validate the use of the proposed International Statistical Classification of Diseases and Related Health Problems (10th revision) (ICD-10) criteria for fatigue (P-ICD10) through comparison with the Functional Assessment of Cancer Therapy Fatigue (FACT-F) subscale and three visual analogue scale (VAS) qualities in cancer patients thought to be fatigued. Fatigue was assessed in 834 cancer patients at three clinical centres in Belgium, using P-ICD10, FACT-F, and VAS to assess: level of energy (VAS1), quality of life (VAS2), and ability to perform daily activities (VAS3). Of the 834 interviewed cancer patients, 54% were classified as fatigued by the P-ICD10 criteria. Internal consistency of P-ICD10 was very good (alpha coefficient 0.82). The principal component analysis corroborated good internal consistency with all variables included in the first component; a second component was used to identify psychological fatigue (concentration and short-term memory disabilities). An abridged set of screening tools based on the first three general symptoms of the P-ICD10 is proposed with 100% specificity and 86% specificity, respectively. There was a marked decrease in FACT-F and VAS1 scores in patients diagnosed as fatigued by the P-ICD10 (mean±SD, FACT-F 20±9 vs 39±8, VAS1 34±21 vs 61±21). A logistic regression model between P-ICD10 criteria diagnosis and FACT-F (VAS1) identified a score of 34 (61) on the FACT-F scale as a proposed cut-off point for the diagnosis of fatigue. The ICD-10 criteria can be recommended as a diagnostic tool, whereas the FACT-F scale and the level of energy 100-mm VAS assess the intensity of fatigue, and are more suitable for follow-up of cancer-related fatigue.

Keywords

Fatigue Assessment Diagnosis Cancer 

Notes

Acknowledgement

The authors want to thank the nursing staff for their assistance in screening the patients.

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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Simon Van Belle
    • 1
    Email author
  • Robert Paridaens
    • 2
  • Georges Evers
    • 2
  • Joseph Kerger
    • 3
  • Dominique Bron
    • 4
  • Jan Foubert
    • 4
  • Gerrit Ponnet
    • 5
  • Didier Vander Steichel
    • 6
  • Christine Heremans
    • 7
  • Dominique Rosillon
    • 8
  1. 1.Medical OncologyUniversity Hospital GhentGentBelgium
  2. 2.University Hospital GasthuisbergLeuvenBelgium
  3. 3.Cliniques Universitaires Mont-GodinneU.C.L.BrusselsBelgium
  4. 4.University Hospital Jules BordetBrusselsBelgium
  5. 5.University Hospital VUBBrusselsBelgium
  6. 6.Féderation Belge contre le CancerBrusselsBelgium
  7. 7.Vlaamse Liga tegen KankerBrusselsBelgium
  8. 8.BiopharmaWavreBelgium

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