Supportive Care in Cancer

, Volume 13, Issue 2, pp 104–108 | Cite as

Delayed emesis: moderately emetogenic chemotherapy

  • Fausto RoilaEmail author
  • David Warr
  • Rebecca A. Clark-Snow
  • Maurizio Tonato
  • Richard J. Gralla
  • Lawrence H. Einhorn
  • Jorn Herrstedt
Review Article


Data on the incidence and efficacy of antiemetic prophylaxis against delayed emesis induced by moderately emetogenic chemotherapy are scanty. An overview of the literature has been done that showed the efficacy of dexamethasone in two of three randomized trials. Its optimal dose and duration of administration has not been defined. Only one of four randomized studies showed a statistically significant efficacy of 5-HT3 antagonists. Finally, only weak evidence has been published on the efficacy of dopamine receptor antagonists.


Delayed emesis Moderately emetogenic chemotherapy Dexamethasone 5-HT3 antagonist 


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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Fausto Roila
    • 1
    Email author
  • David Warr
    • 2
  • Rebecca A. Clark-Snow
    • 3
  • Maurizio Tonato
    • 4
  • Richard J. Gralla
    • 5
  • Lawrence H. Einhorn
    • 6
  • Jorn Herrstedt
    • 7
  1. 1.Medical Oncology DivisionPoliclinico HospitalPerugiaItaly
  2. 2.Department of Medical Oncology and HematologyPrincess Margaret HospitalTorontoCanada
  3. 3.University of Kansas Cancer CenterKansas CityUSA
  4. 4.Medical Oncology DivisionPoliclinico HospitalPerugiaItaly
  5. 5.New York Lung Cancer AllianceNew YorkUSA
  6. 6.Walther Cancer InstituteIndianapolisUSA
  7. 7.Department of OncologyCopenhagen University Hospital HerlevCopenhagenDenmark

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