Increased intermediate monocyte fraction in peripheral blood is associated with nonalcoholic fatty liver disease
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Nonalcoholic fatty liver disease (NAFLD) currently represents the most common hepatic disease worldwide and is closely linked to cardiovascular disease, obesity and diabetes mellitus. This study aimed to investigate NAFLD and its influence on different monocyte subpopulations to determine the presence of significant associations. A total of 3 monocyte subpopulations were investigated, i.e. classical (CD14++CD16−), intermediate (CD14++CD16+) and non-classical (CD14+CD16++). Of the participants 261 were included in this study (n = 53 with NAFLD, n = 208 controls). Ultrasonography was used to diagnose NAFLD and exclude other morphologic causes of liver diseases and other tests (including medical history inquiries and detection of hepatitis virus) were performed to exclude other causes of parenchymal liver disease. Classical inflammatory and metabolic-related NAFLD biomarkers were also determined. In contrast to the healthy control group, the intermediate monocyte fraction was increased in NAFLD patients (p = 0.032), while the classical monocyte fraction was decreased (p = 0.025). Intermediate monocyte fraction, body mass index (BMI) and tumor necrosis factor alpha (TNF-α) were independent risk factors for NAFLD. Classical, non-classical and intermediate monocytes fraction were strongly associated with age, triglyceride, and waist circumference. This study suggests that the intermediate monocyte fraction in peripheral blood is likely related to the aggravation of NAFLD.
KeywordsMonocytes Intermediate monocytes Nonalcoholic fatty liver disease
Body mass index
Fasting plasma glucose
High-density lipoprotein cholesterol
Homeostasis model assessment-estimated insulin resistance
Low-density lipoprotein cholesterol
Nonalcoholic fatty liver disease
Natural killer cells
Peripheral blood monocytes
Tumor necrosis factor alpha
This work was supported by grants from the National Natural Science Foundation of China (grant no. 81400828) and the Natural Science Foundation of Shandong Province (grant no. ZR2014HQ057).
Conflict of interest
J. Zhang, W. Chen, L. Fang, Q. Li, X. Zhang, H. Zhang, Q. Guan, R. Zhao, C. Yang, and F. Jing declare that they have no competing interests.
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