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Wiener klinische Wochenschrift

, Volume 129, Issue 15–16, pp 527–532 | Cite as

Cystic fibrosis in Austria

  • Thomas FrischerEmail author
  • Ernst Eber
  • Helmut Ellemunter
  • Angela Zacharasiewicz
  • Ingrid Kaluza
  • Josef Riedler
  • Sabine Renner
original article
  • 252 Downloads

Summary

Registry data for patients with cystic fibrosis (CF) are increasingly used to evaluate the natural history, for benchmarking of therapy and in order to identify eligible patients for clinical studies. So far, no data on frequency and clinical status of CF patients have been available for Austria on a national level. We collected data of CF patients treated 2014 in Austrian CF outpatient clinics by means of a European CF registry and on an individual search basis. A total of 773 CF patients with a median age of 18.9 years (SD 11.8 years) were seen in 13 centers (18–151 patients/center). Homozygous F508del mutation being the most common genotype was observed in 48.8% of patients. Mean age at diagnosis was 27 days. In 59% of all patients FEV1% predicted (Forced Exspiratory Volume in 1 second) was <80% and in 20% <50%. An average FEV1 predicted decline per year of 1.9% was observed between 6–18 years of age. Colonisation with Pseudomonas aeruginosa ranged between 12% and 69% in adult patients and in 0–16% in children with CF. Burkholderia cepacia complex species were present in a total of 29 samples (3.8%). Insulin therapy for diabetes was given in 14.5%. Liver involvement was reported in 36.3%. A wide variation of prescribed CF therapy was observed between centers. Data on CF patients living in Austria are now available and form a basis for clinical benchmarking as well as analyses from a public health perspective.

Keywords

Cystic fibrosis Patient registry Epidemiology 

Notes

Conflict of interest

T. Frischer, E. Eber, H. Ellemunter, A. Zacharasiewicz, I. Kaluza, J. Riedler, and S. Renner declare that they have no competing interests.

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Copyright information

© Springer-Verlag Wien 2017

Authors and Affiliations

  1. 1.Department of Pediatrics and Adolescent MedicineWilhelminenspitalViennaAustria
  2. 2.Department of Pneumology and AllergologyUniversity Children’s Hospital of GrazGrazAustria
  3. 3.Department of Pediatrics and Adolescent medicineUniversity Children’s Hospital of InnsbruckInnsbruckAustria
  4. 4.Department of PneumologyKrankenhaus HietzingViennaAustria
  5. 5.Department of Pediatrics and Adolescent MedicineKardinal Schwarzenberg’sches KrankenhausSchwarzachAustria
  6. 6.Department of Pneumology, Allergology and EndocrinologyUniversity Children’s Hospital of ViennaViennaAustria

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