First mid-term results after cancellous allograft vitalized with autologous bone marrow for infected femoral non-union
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Surgical treatment of infected femoral non-union is challenging. Only few reports exist including autologous bone grafting (ABG) from the iliac crest promoting union. Vitalized allogeneic bone grafting (VABG) is an alternative promoting osseous healing and reconstructing bone defects. VABG contains allogeneic cancellous bone, impregnated with autologous bone marrow puncture harvested from the iliac crest. Yet, no systematic trial exists summarizing the results of septic femoral non-union using VABG analyzing the infection eradication rate, rate of osseous integration with union, and osseous remodeling.
In this prospective non-randomized cohort study, 18 patients treated by nailing or plating for femur fractures that subsequently developed a septic non-union were included. The surgical intervention included a standardized protocol by eradicating infection first, followed by implantation VABG to promote osseous union. Main outcome measurements were radiographic union and clinical parameters.
Mean follow-up was 5.9 years (range: 2–8 years). Infection eradication was achieved for all patients, while union was achieved in 15 out of 18 cases (83.3 %). Mean time for union took 16.9 weeks (range: 12–24). Radiographic analysis proved osseous remodeling and full integration of VABG within 12 months for 15 patients. No infection recurrence occurred at final follow-up.
VABG demonstrated a high union rate without donor site morbidity as the main advantage over ABG. Sufficient osseous integration within 3 months and remodeling within 12 months are promising aspects, as no late fatigue fractures occurred. However, further trials are necessary due to the limitations of this study.
KeywordsSeptic non-union Femoral pseudarthrosis Osteomyelitis Bone defect Allograft Autologous bone graft
- 1.Jain AK, Sinha S. Infected nonunion of the long bones. Clin Orthop Relat Res. 2005;431:57–65.Google Scholar
- 6.Babhulkar S, Pande K. Nonunion of the diaphysis of long bones. Clin Orthop Relat Res. 2005;431:50–6.Google Scholar
- 8.Cattaneo R, Catagni M, Johnson EE. The treatment of infected nonunions and segmental defects of the tibia by the methods of Ilizarov. Clin Orthop Relat Res. 1992;280:143–52.Google Scholar
- 10.Finkemeier CG, Chapman MW. Treatment of femoral diaphyseal nonunions. Clin Orthop Relat Res. 2002;398:223–34.Google Scholar
- 19.Miller ME, Ada JR, Webb LX. Treatment of infected nonunion and delayed union of tibia fractures with locking intramedullary nails. Clin Orthop Relat Res. 1989;245:233–8.Google Scholar
- 20.Gomez-Barrena E et al. Bone fracture healing: cell therapy in delayed unions and nonunions. Bone. 2015;70:93–101.Google Scholar
- 30.Alonso J, Geissler W, Hughes JL. External fixation of femoral fractures. Indications and limitations. Clin Orthop Relat Res. 1989;241:83–8.Google Scholar
- 32.Ochsner PE, Hailemariam S. Histology of osteosynthesis associated bone infection. Injury. 2006;37(Suppl. 2):S49–58.Google Scholar