Wiener klinische Wochenschrift

, Volume 127, Issue 11–12, pp 494–496 | Cite as

Monogenic glucokinase diabetes and pregnancy: a case study

  • Iva HaladováEmail author
  • Daniela Čechurová
  • Silvie Lacigová
  • Zdeněk Rušavý
case report


It is estimated that up to 3 % of patients with gestational diabetes have glucokinase diabetes, termed also maturity-onset diabetes of the young type 2. The disorder has autosomal dominant inheritance. There is a 50 % risk of transmission of the gene to next generation. Two scenarios with different approach to the treatment may occur in pregnancy with glucokinase diabetes: either the fetus inherits the glucokinase mutation and the treatment of maternal hyperglycemia by insulin could increase the risk of fetal growth restriction, or the fetus is without glucokinase gene mutation and untreated hyperglycemia of the mother increases the risk of macrosomia and perinatal morbidity and insulin therapy is necessary. This article describes the outcome of two pregnancies in a patient with monogenic diabetes with glucokinase deficiency. A specific approach to the treatment is discussed.


Glucokinase diabetes Monogenic diabetes MODY 2 Pregnancy Insulin therapy 


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Copyright information

© Springer-Verlag Wien 2015

Authors and Affiliations

  • Iva Haladová
    • 1
    Email author
  • Daniela Čechurová
    • 1
  • Silvie Lacigová
    • 1
  • Zdeněk Rušavý
    • 1
  1. 1.Department of Medicine IUniversity Hospital and Medical Faculty in Pilsen, Charles University in PraguePilsenCzech Republic

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