Advertisement

Wiener klinische Wochenschrift

, Volume 127, Issue 11–12, pp 494–496 | Cite as

Monogenic glucokinase diabetes and pregnancy: a case study

  • Iva HaladováEmail author
  • Daniela Čechurová
  • Silvie Lacigová
  • Zdeněk Rušavý
case report
  • 213 Downloads

Summary

It is estimated that up to 3 % of patients with gestational diabetes have glucokinase diabetes, termed also maturity-onset diabetes of the young type 2. The disorder has autosomal dominant inheritance. There is a 50 % risk of transmission of the gene to next generation. Two scenarios with different approach to the treatment may occur in pregnancy with glucokinase diabetes: either the fetus inherits the glucokinase mutation and the treatment of maternal hyperglycemia by insulin could increase the risk of fetal growth restriction, or the fetus is without glucokinase gene mutation and untreated hyperglycemia of the mother increases the risk of macrosomia and perinatal morbidity and insulin therapy is necessary. This article describes the outcome of two pregnancies in a patient with monogenic diabetes with glucokinase deficiency. A specific approach to the treatment is discussed.

Keywords

Glucokinase diabetes Monogenic diabetes MODY 2 Pregnancy Insulin therapy 

References

  1. 1.
    Lebl J, Průhová Š. Monogenně podmíněné formy DM. In: Škrha J et al., editors. Diabetologie. 1st ed. Praha: Galen; 2009. pp. 119–22.Google Scholar
  2. 2.
    Ellard S, Beards F, Allen LIS, et al. A high prevalence of glucokinase mutations in gestational diabetic subjects selected by clinical criteria. Diabetologia. 2000;43:250–3.PubMedCrossRefGoogle Scholar
  3. 3.
    Stride A, Vaxillaire M, Tuomi T, et al. The genetic abnormality in the beta cell determines the response to an oral glucose load. Diabetologia. 2002;45(3):427–35.Google Scholar
  4. 4.
    Ray JG, O’Brien TE, Chan WS. Preconception care and the risk of congential anomalies in the offspring of women with diabetes mellitus: a meta analysis. Q J Med. 2001;94:435–44.CrossRefGoogle Scholar
  5. 5.
    Lebl J, Průhová Š. Monogenní diabetes mellitus: od genetiky kléčbě. Praha: Maxdorf; 2009. pp. 13–15.Google Scholar
  6. 6.
    Hattersley AT, Beards F, Ballantyne E, et al. Mutations in the glucokinase gene of the fetus result in reduced birth weight. Nat Genet. 1998;19:268–70.PubMedCrossRefGoogle Scholar
  7. 7.
    Tartaglia E, Iafusco D, Giuliano P, et al. Comment on: Chakera et al. Antenatal diagnosis of fetal genotype determines if maternal hyperglycemia due to a glucokinase mutation requires treatment. Diabetes Care. 2013;36:14.Google Scholar
  8. 8.
    Spyer G, Macleod KM, Shepherd M, et al. Pregnancy outcome in patients with raised blood glucose due to a heterozygous glucokinase gene mutation. Diabet Med. 2009;26:14–18.PubMedCrossRefGoogle Scholar
  9. 9.
    Chakera A, Carleton V, Ellard S, et al. Antenatal diagnosis of fetal genotype determines if maternal hyperglycemia due to a glucokinase mutation requires treatment. Diabetes Care. 2012;35(9):1832–4.Google Scholar
  10. 10.
    Chiu RW, Chan KC, Gao Y, et al. Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma. Proc Natl Acad Sci U S A. 2008;105:20458–63.Google Scholar

Copyright information

© Springer-Verlag Wien 2015

Authors and Affiliations

  • Iva Haladová
    • 1
    Email author
  • Daniela Čechurová
    • 1
  • Silvie Lacigová
    • 1
  • Zdeněk Rušavý
    • 1
  1. 1.Department of Medicine IUniversity Hospital and Medical Faculty in Pilsen, Charles University in PraguePilsenCzech Republic

Personalised recommendations