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Wiener klinische Wochenschrift

, Volume 124, Issue 21–22, pp 737–741 | Cite as

Association between KCNE1 (G38S) genetic polymorphism and non-valvular atrial fibrillation in an Uygur population

  • Miao Haijun
  • Zhou Xiaohui
  • Mao Ting
  • Wilfried Renner
  • Palida Abulizi
  • Tang BaopengEmail author
original article

Summary

Background

The relationship between KCNE1 G38S genetic polymorphism and non-valvular atrial fibrillation is different among different populations. The study explored the KCNE1 G38S to understand if the KCNE1 G38S is associated with the Uygur atrial fibrillation patients.

Methods

KCNE1 G38S genetic polymorphism was determined between 237 non-valvular atrial fibrillation cases and 237 control subjects using PCR-RFLP.

Results

In univariate analyses, there was a statistical difference in genotype distribution between the patients and controls, and a significant difference in allele frequency of KCNE1 G38S was observed between the two groups (62.6 vs 52.7 %, p = 0.003). In multivariate analyses, the KCNE1 38G variant was independently associated with a significant predisposing effect on AF after adjusting for related risk factors, and the odds ratio for patients was 1.634 (95 % CI: 1.192–2.240, p = 0.002).

Conclusion

The KCNE1 38G is a risk factor for incident AF in an Uygur population. The KCNE1 G38S might have different impact on AF in different ethnicities.

Keywords

Atrial fibrillation KCNE1 gene Uygur ethnicity Han ethnicity 

Zusammenhang zwischen KCNE1 (G38S) genetischem Polymorphismus und nicht-valvulärem Vorhofflimmern bei einer Uygur-Population

Zusammenfassung

Grundlagen

Die Beziehung zwischen KCNE1 (G38S) genetischem Polymorphismus und nicht valvulärem Vorhofflimmern variiert bei verschiedenen Populationen. Unsere Studie untersucht das KCNE1 (G38S) um zu erforschen, ob damit bei Patienten mit Vorhofflimmern einer Uygur-Bevölkerung ein Zusammenhang besteht.

Methodik

Der genetische KCNE G38S Polymorphismus zwischen 237 Patienten mit nicht-valvulärem Vorhofflimmern und 237 Kontrollpersonen wurde mittels PCR-RFLP bestimmt.

Ergebnisse

In der univariaten Analyse ergab sich ein statistisch signifikanter Unterschied in der Genotyp-Verteilung der Patienten im Vergleich zur Kontrolle. Es bestand eine signifikante Differenz in der Frequenz der Allele des KCNE1 G38S der beiden Gruppen: 62,6 vs 52,7 %; p = 0,003. In der multivariaten Analyse zeigte sich, dass die KCNE1 38G Variante selbst nach Berücksichtigung entsprechender Risikofaktoren einen unabhängigen signifikanten prädisponierenden Risikofaktor für Vorhofflimmern darstellt. Es wurden folgende Odd Ratios für die Patienten erhoben: 1.634 (95 % CI: 1,192–2,240, p = 0,002)

Schlussfolgerung

KCNE1 38G ist in einer Uygur-Population ein Risikofaktor für Vorhofflimmern. Bei anderen Bevölkerungsgruppen könnte KCNE1 G38S eine unterschiedliche Bedeutung für die Entstehung von Vorhofflimmern haben.

Schlüsselwörter

Vorhofflimmern KCNE1 Gen Uygur Ethnizität Han Ethnizität 

Notes

Conflict of interest

The authors declare that there is no actual or potential conflict of interest in relation to this article.

References

  1. 1.
    Feinberg WM, Blackshear JL, Laupacis A, et al. Prevalence, age distribution and gender of patients with atrial fibrillation: analysis and implications. Arch Intern Med. 1995;155(5):469–73.PubMedCrossRefGoogle Scholar
  2. 2.
    Go AS, Hylek EM, Phillips KA, et al. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the anticoagulation and risk factors in atrial fibrillation (ATRIA) study. JAMA. 2001;285(18):2370–5.PubMedCrossRefGoogle Scholar
  3. 3.
    Baine WB, Yu W, Weis KA. Trends and outcomes in the hospitalization of older Americans for cardiac conduction disorders or arrhythmias, 1991–1998. J Am Geriatr Soc. 2001;49(6):763–70.PubMedCrossRefGoogle Scholar
  4. 4.
    Goldberg RJ, Yarzebski J, Lessard D, et al. Recent trends in the incidence rates of and death rates from atrial fibrillation complicating initial acute myocardial infarction: a community-wide perspective. Am Heart J. 2002;143(3):519–27.PubMedCrossRefGoogle Scholar
  5. 5.
    Stewart S, MacIntyre K, Macleod MM, et al. Trends in hospital activity, morbidity and case fatality related to atrial fibrillation in Scotland, 1986–1996. Eur Heart J. 2001;22(8):693–701.PubMedCrossRefGoogle Scholar
  6. 6.
    Wolf PA, Benjamin EJ, Belanger AJ, et al. Secular trends in the prevalence of atrial fibrillation: the Framingham Study. Am Heart J. 1996;131(4):790–5.PubMedCrossRefGoogle Scholar
  7. 7.
    Miyasaka Y, Barnes M, Gersh B, et al. Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980–2000, and implications on the projections for future prevalence. Circulation. 2006;114(2):119–25.PubMedCrossRefGoogle Scholar
  8. 8.
    Arnar DO, Thorvaldsson S, Manolio TA, et al. Familial aggregation of atrial fibrillation in Iceland. Eur Heart J. 2006;27(6):708–12.PubMedCrossRefGoogle Scholar
  9. 9.
    Brugada R. Is atrial fibrillation a genetic disease? J Cardiovasc Electrophysiol. 2005;16(5):553–6.PubMedCrossRefGoogle Scholar
  10. 10.
    Darbar D, Herron KJ, Ballew JD, et al. Familial atrial fibrillation is a genetically heterogeneous disorder. J Am Coll Cardiol. 2003;41(12):2185–92.PubMedCrossRefGoogle Scholar
  11. 11.
    Fox CS, Parise H, D’Agostino RB, et al. Parental atrial fibrillation as a risk factor for atrial fibrillation in offspring. JAMA. 2004;291(23):2851–5.PubMedCrossRefGoogle Scholar
  12. 12.
    Lai LP, Su MJ, Yeh HM, et al. Association of the human minK gene 38G allele with atrial fibrillation: evidence of possible genetic control on the pathogenesis of atrial fibrillation. Am Heart J. 2002;144(3):485–90.PubMedCrossRefGoogle Scholar
  13. 13.
    Zhiyu Z, Chen T, Siyong T, et al. The single nucleotide polymorphisms of IKs potassium channel genes and their association with atrial fibrillation in a Chinese population. Cardiology. 2007;108(2):97–103.CrossRefGoogle Scholar
  14. 14.
    Fatini C, Sticchi E, Genuardi M, et al. Analysis of minK and eNOS genes as candidate loci for predisposition to non-valvular atrial fibrillation. Eur Heart J. 2006;27(14):1712–8.PubMedCrossRefGoogle Scholar
  15. 15.
    Prystupa A, Dzida G, Myslinski W, Malaj G, Lorenc T. MinK gene polymorphism in the pathogenesis of lone atrial fibrillation. Kardiol Pol. 2006;64(11):1205–11.PubMedGoogle Scholar
  16. 16.
    Jun Z Li, Devin MA, Hua T, et al. Worldwide human relationships inferred from genome-wide patterns of variation. Science. 2008;319(5866):1100–4.CrossRefGoogle Scholar
  17. 17.
    Ai Q, Xiao H, Zhao J, et al. A survey on physical characteristics of Uygur Nationality. ACTA Anthropologica Sinica. 1993;12(4):357–65.Google Scholar
  18. 18.
    Mancia G, De Backer G, Dominiczak A, et al. Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J. 2007;28(12):1462–536.PubMedGoogle Scholar
  19. 19.
    Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diab Care. 2003;26(1):5–20.Google Scholar
  20. 20.
    Barhanin J, Lesage F, Guillemare E, et al. KvLQT1 and Isk (minK) proteins associate to form the Isk cardiac potassium current. Nature. 1996;384(6604):78–80.PubMedCrossRefGoogle Scholar
  21. 21.
    Sanguinetti MC, Curran ME, Zou A, et al. Coassembly of KvLQT1 and mink (IsK) proteins to form cardiac Iks potassium channel. Nature. 1996;384(6604):80–3.PubMedCrossRefGoogle Scholar
  22. 22.
    Chen Y-H, Xu SJ, Bendahhou S, et al. KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science. 2003;299(5604):251–4.PubMedCrossRefGoogle Scholar
  23. 23.
    Ehrlich JR, Zicha S, Coutu P, Hebert TE, Nattel S. Atrial fibrillation-associated minK 38G/S polymorphism modulates delayed rectifier current and membrane localization. Cardiovasc Res. 2005;67(3):520–8.PubMedCrossRefGoogle Scholar
  24. 24.
    Xu S, Huang W, Qian J, Jin L. Analysis of genomic admixture in Uygur and its implication in mapping strategy. Am J Hum Genet. 2008;82(4):883–94.PubMedCrossRefGoogle Scholar
  25. 25.
    Gregory MM, Alvaro A, Carmen AP, et al. European ancestry as a risk factor for atrial fibrillation in African Americans. Circulation. 2010;122(20):2009–15.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 2012

Authors and Affiliations

  • Miao Haijun
    • 1
  • Zhou Xiaohui
    • 1
  • Mao Ting
    • 1
  • Wilfried Renner
    • 2
  • Palida Abulizi
    • 1
  • Tang Baopeng
    • 1
    Email author
  1. 1.The Cardiac Pacing and Electrophysiological DivisionThe first teaching hospital of Xinjiang Medical UniversityUrumqiChina
  2. 2.Clinical Institute of Medical and Chemical Laboratory DiagnosticsMedical University of GrazGrazAustria

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