Wiener klinische Wochenschrift

, Volume 124, Issue 21–22, pp 737–741 | Cite as

Association between KCNE1 (G38S) genetic polymorphism and non-valvular atrial fibrillation in an Uygur population

  • Miao Haijun
  • Zhou Xiaohui
  • Mao Ting
  • Wilfried Renner
  • Palida Abulizi
  • Tang BaopengEmail author
original article



The relationship between KCNE1 G38S genetic polymorphism and non-valvular atrial fibrillation is different among different populations. The study explored the KCNE1 G38S to understand if the KCNE1 G38S is associated with the Uygur atrial fibrillation patients.


KCNE1 G38S genetic polymorphism was determined between 237 non-valvular atrial fibrillation cases and 237 control subjects using PCR-RFLP.


In univariate analyses, there was a statistical difference in genotype distribution between the patients and controls, and a significant difference in allele frequency of KCNE1 G38S was observed between the two groups (62.6 vs 52.7 %, p = 0.003). In multivariate analyses, the KCNE1 38G variant was independently associated with a significant predisposing effect on AF after adjusting for related risk factors, and the odds ratio for patients was 1.634 (95 % CI: 1.192–2.240, p = 0.002).


The KCNE1 38G is a risk factor for incident AF in an Uygur population. The KCNE1 G38S might have different impact on AF in different ethnicities.


Atrial fibrillation KCNE1 gene Uygur ethnicity Han ethnicity 

Zusammenhang zwischen KCNE1 (G38S) genetischem Polymorphismus und nicht-valvulärem Vorhofflimmern bei einer Uygur-Population



Die Beziehung zwischen KCNE1 (G38S) genetischem Polymorphismus und nicht valvulärem Vorhofflimmern variiert bei verschiedenen Populationen. Unsere Studie untersucht das KCNE1 (G38S) um zu erforschen, ob damit bei Patienten mit Vorhofflimmern einer Uygur-Bevölkerung ein Zusammenhang besteht.


Der genetische KCNE G38S Polymorphismus zwischen 237 Patienten mit nicht-valvulärem Vorhofflimmern und 237 Kontrollpersonen wurde mittels PCR-RFLP bestimmt.


In der univariaten Analyse ergab sich ein statistisch signifikanter Unterschied in der Genotyp-Verteilung der Patienten im Vergleich zur Kontrolle. Es bestand eine signifikante Differenz in der Frequenz der Allele des KCNE1 G38S der beiden Gruppen: 62,6 vs 52,7 %; p = 0,003. In der multivariaten Analyse zeigte sich, dass die KCNE1 38G Variante selbst nach Berücksichtigung entsprechender Risikofaktoren einen unabhängigen signifikanten prädisponierenden Risikofaktor für Vorhofflimmern darstellt. Es wurden folgende Odd Ratios für die Patienten erhoben: 1.634 (95 % CI: 1,192–2,240, p = 0,002)


KCNE1 38G ist in einer Uygur-Population ein Risikofaktor für Vorhofflimmern. Bei anderen Bevölkerungsgruppen könnte KCNE1 G38S eine unterschiedliche Bedeutung für die Entstehung von Vorhofflimmern haben.


Vorhofflimmern KCNE1 Gen Uygur Ethnizität Han Ethnizität 


Conflict of interest

The authors declare that there is no actual or potential conflict of interest in relation to this article.


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Copyright information

© Springer-Verlag Wien 2012

Authors and Affiliations

  • Miao Haijun
    • 1
  • Zhou Xiaohui
    • 1
  • Mao Ting
    • 1
  • Wilfried Renner
    • 2
  • Palida Abulizi
    • 1
  • Tang Baopeng
    • 1
    Email author
  1. 1.The Cardiac Pacing and Electrophysiological DivisionThe first teaching hospital of Xinjiang Medical UniversityUrumqiChina
  2. 2.Clinical Institute of Medical and Chemical Laboratory DiagnosticsMedical University of GrazGrazAustria

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