Wiener klinische Wochenschrift

, Volume 124, Issue 9–10, pp 334–339

Leitlinie zur Prävention und Früherkennung von Brust- und Eierstockkrebs bei Hochrisikopatientinnen, insbesondere bei Frauen aus HBOC (Hereditary Breast and Ovarian Cancer) Familien

  • Christian F. Singer
  • Muy-Kheng Tea
  • Gunda Pristauz
  • Michael Hubalek
  • Christine Rappaport
  • Christopher Riedl
  • Thomas Helbich
konsensus bericht

Zusammenfassung

Die vorliegende österreichische Leitlinie zur Prävention und Früherkennung von Brust- und Eierstockkrebs bei Hochrisikopatientinnen – insbesondere bei Frauen aus HBOC-Familien – wurde unter der besonderen Berücksichtigung des aktuellen EUSOMA (European Society of Breast Cancer Specialists) Positionspapiers von oben angeführten Experten gemeinsam erstellt. Die Leitlinie soll die Betreuung von Frauen mit einem erhöhtem Lebenszeitrisiko für Brust- und/oder Eierstockkrebs standardisieren und vereinfachen.

Schlüsselwörter

BRCA Hereditärer Brustkrebs Früherkennung Prophylaktische Operationen 

Guideline for the prevention and early detection of breast and ovarian cancer in high risk patients, particularly in women from HBOC (hereditary breast and ovarian cancer) families

Summary

The Austrian guideline for prevention and early detection of breast and ovarian cancer in high risk patients—particularly in women from hereditary breast and ovarian cancer families—were established with particular consideration of the most recent position paper of the European Society of Breast Cancer Specialists (EUSOMA) by the authors mentioned above. The guideline is aimed at facilitating and standardizing the care and early detection strategies in women with an elevated life time risk for breast and ovarian cancer.

Keywords

BRCA Hereditary breast and ovarian cancer Breast cancer early detection Guideline 

Literatur

  1. 1.
    Sardanelli F, Boetes C, Borisch B, Decker T, Federico M, Gilbert FJ, et al. Magnetic resonance imaging of the breast: recommendations from the EUSOMA working group. Eur J Cancer. 2010 May;46(8):1296–316.PubMedCrossRefGoogle Scholar
  2. 2.
    Jatoi I, Anderson WF. Management of women who have a genetic predisposition for breast cancer. Surg Clin North Am. 2008 Aug;88(4):845–61.PubMedCrossRefGoogle Scholar
  3. 3.
    Sardanelli F, Podo F. Management of an inherited predisposition to breast cancer. N Engl J Med. 2007 Oct 18;357(16):1663.PubMedCrossRefGoogle Scholar
  4. 4.
    Sardanelli F, Podo F. Breast MR imaging in women at high-risk of breast cancer. Is something changing in early breast cancer detection? Eur Radiol. 2007 Apr;17(4):873–87.PubMedCrossRefGoogle Scholar
  5. 5.
    Warner E, Plewes DB, Hill KA, Causer PA, Zubovits JT, Jong RA, et al. Surveillance of BRCA1 and BRCA2 mutation carriers with magnetic resonance imaging, ultrasound, mammography, and clinical breast examination. JAMA. 2004 Sep 15;292(11):1317–25.PubMedCrossRefGoogle Scholar
  6. 6.
    Riedl CC, Ponhold L, Flöry D, Weber M, Kroiss R, Wagner T, et al. Magnetic resonance imaging of the breast improves detection of invasive cancer, preinvasive cancer, and premalignant lesions during surveillance of women at high risk for breast cancer. Clin Cancer Res. 2007 Oct 15;13(20):6144–52.PubMedCrossRefGoogle Scholar
  7. 7.
    Kriege M, Brekelmans CT, Obdeijn IM, Boetes C, Zonderland HM, Muller SH, et al. Factors affecting sensitivity and specificity of screening mammography and MRI in women with an inherited risk for breast cancer. Breast Cancer Res Treat. 2006 Nov;100(1):109–19.PubMedCrossRefGoogle Scholar
  8. 8.
    www.krebshilfe.net.Google Scholar
  9. 9.
    Domchek SM, Friebel TM, Singer CF, Evans DG, Lynch HT, Isaacs C, et al. Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality. JAMA. 2010 Sep 1;304(9):967–75.PubMedCrossRefGoogle Scholar
  10. 10.
    Kauff ND, Domchek SM, Friebel TM, Robson ME, Lee J, Garber JE, et al. Risk-reducing salpingo-oophorectomy for the prevention of BRCA1- and BRCA2-associated breast and gynecologic cancer: a multicenter, prospective study. J Clin Oncol. 2008 Mar 10;26(8):1331–7.PubMedCrossRefGoogle Scholar
  11. 11.
    Metcalfe K, Lynch HT, Ghadirian P, Tung N, Olivotto I, Warner E, et al. Contralateral breast cancer in BRCA1 and BRCA2 mutation carriers. J Clin Oncol. 2004 Jun 15;22(12):2328–35.PubMedCrossRefGoogle Scholar
  12. 12.
    Lostumbo L, Carbine NE, Wallace J. Prophylactic mastectomy for the prevention of breast cancer. Cochrane Database Syst Rev. 2010 Nov 10;(11):CD002748.Google Scholar
  13. 13.
    Rebbeck TR, Friebel T, Lynch HT, Neuhausen SL, van’t Veer L, Garber JE, et al. Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group. J Clin Oncol. 2004 Mar 15;22(6):1055–62.PubMedCrossRefGoogle Scholar
  14. 14.
    Metcalfe KA. Oophorectomy for breast cancer prevention in women with BRCA1 or BRCA2 mutations. Womens Health (Lond Engl). 2009 Jan;5(1):63–8.CrossRefGoogle Scholar
  15. 15.
    Interdisziplinäre S3-Leitlinie für die Diagnostik, Therapie und Nachsorge des Mammakarzinoms; W. Zuckschwerdt Verlag GmbH,Aktualisierung 2008; ISBN 978-3-88603-934-0.Google Scholar
  16. 16.
    Balmaña J, Díez O, Castiglione M, ESMO Guidelines Working Group. BRCA in breast cancer: ESMO clinical recommendations. Ann Oncol. 2009 May;20(Suppl 4):19–20.Google Scholar
  17. 17.
    ACOG and SGO Practice Bulletin. Hereditary breast an ovarian syndrome. Am J Obstet Gynecol. 2009;113:957–65.Google Scholar
  18. 18.
    Horsman D, Wilson BJ, Avard D, Meschino WS, Kim Sing C, Plante M, et al. Clinical management recommendations for surveillance and risk-reduction strategies for hereditary breast and ovarian cancer among individuals carrying a deleterious BRCA1 or BRCA2 mutation. National Hereditary Cancer Task Force. J Obstet Gynaecol Can. 2007 Jan;29(1):45–60.PubMedGoogle Scholar
  19. 19.
    Saslow D, Boetes C, Burke W, Harms S, Leach MO, Lehman CD, et al. American cancer society guidelines for breast screening with MRI as an adjunct to mammography. CA Cancer J Clin. 2007 Mar-Apr;57(2):75–89.PubMedCrossRefGoogle Scholar
  20. 20.
    http://www.breastsurgeons.org/statements/brca.php.Google Scholar

Copyright information

© Springer-Verlag Wien 2012

Authors and Affiliations

  • Christian F. Singer
    • 1
  • Muy-Kheng Tea
    • 1
  • Gunda Pristauz
    • 2
  • Michael Hubalek
    • 3
  • Christine Rappaport
    • 1
  • Christopher Riedl
    • 4
  • Thomas Helbich
    • 4
  1. 1.Universitätsklinik für Frauenheilkunde, MUW/AKH WienWienÖsterreich
  2. 2.Universitätsfrauenklinik Graz, Abt. für GynäkologieGrazÖsterreich
  3. 3.Universitätsfrauenklinik Innsbruck, Brustgesundheitszentrum TirolTirolÖsterreich
  4. 4.Universitätsklinik für Radiodiagnostik, MUW/AKH WienWienÖsterreich

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