Wiener klinische Wochenschrift

, Volume 121, Issue 9–10, pp 330–333 | Cite as

Heart rate-corrected QT interval and QT dispersion in patients with pulmonary hypertension

  • Zhang Hong-liang
  • Luo Qin
  • Liu Zhi-hong
  • Zhao Zhi-hui
  • Xiong Chang-ming
  • Ni Xin-hai
  • He Jian-guo
  • Wei Ying-jie
  • Zhang Shu
Original article

Summary

OBJECTIVE: Heart rate-corrected QT interval (QTc) and QTc dispersion (QTcd) are increased and associated with ventricular arrhythmia and an increase in sudden death in a variety of diseases. This study aimed to examine QTc and QTcd in pulmonary hypertension and assess their relationship with pulmonary arterial pressure. PATIENTS AND METHODS: A total of 201 patients who had undergone right heart catheterization for a preliminary diagnosis of pulmonary hypertension between December 2003 and July 2008 were included in the study. Resting 12-lead electrocardiogram was recorded. QT interval was measured manually and corrected using Bazett's formula. Patients were divided into groups with mild-to-moderate and severe pulmonary hypertension and a control group according to mean pulmonary arterial pressure. RESULTS: In all observed cases, mean QTc was higher in severe pulmonary hypertension than in controls (428.6 ± 32.8 ms vs. 411.1 ± 28.4 ms, P = 0.018) and QTcd was higher in mild-to-moderate (60.1 ± 17.2 ms) and severe pulmonary hypertension (63.9 ± 20.5 ms) than in controls (47.3 ± 10.6 ms) (P = 0.031; P = 0.004). In men, there was no significant difference in mean QTc and QTcd. In women, mean QTc was higher in severe pulmonary hypertension than in controls (436.1 ± 39.4 ms vs. 407.6 ± 24.8 ms, P = 0.037) and QTcd was higher in severe pulmonary hypertension (68.5 ± 20.9 ms) than in both the controls (45.1 ± 12.6 ms) and patients with mild-to-moderate pulmonary hypertension (58.6 ± 14.7ms) (P = 0.002; P = 0.003). In addition, in women with pulmonary hypertension, mean QTc and QTcd were positively correlated to mean pulmonary arterial pressure (r = 0.207, P = 0.03; r = 0.236, P = 0.012). CONCLUSIONS: In women with pulmonary hypertension, mean QTc and QTcd are positively correlated to mean pulmonary arterial pressure and are significantly increased in patients with severe pulmonary hypertension.

Keywords

Pulmonary hypertension QT interval QT dispersion Electrocardiogram Pulmonary arterial pressure/heart catheterization 

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Zhang Hong-liang
    • 1
  • Luo Qin
    • 1
  • Liu Zhi-hong
    • 1
  • Zhao Zhi-hui
    • 1
  • Xiong Chang-ming
    • 1
  • Ni Xin-hai
    • 1
  • He Jian-guo
    • 1
  • Wei Ying-jie
    • 2
  • Zhang Shu
    • 3
  1. 1.Center for Pulmonary Vascular Disease, Fuwai Hospital & Cardiovascular InstituteChinese Academy of Medical Sciences & Peking Union Medical CollegeBeijingChina
  2. 2.Key Laboratory of Cardiovascular Regenerative Medicine, Fuwai Hospital & Cardiovascular InstituteChinese Academy of Medical Sciences & Peking Union Medical CollegeBeijingChina
  3. 3.Center for Cardiac Arrhythmia, Fuwai Hospital & Cardiovascular InstituteChinese Academy of Medical Sciences & Peking Union Medical CollegeBeijingChina

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