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Wiener klinische Wochenschrift

, Volume 118, Issue 19–20, pp 568–570 | Cite as

Viral vectors as a tool to model and treat Parkinson's disease

  • Jean-Charles Bensadoun
  • Patrick Aebischer
Current Topics in Brain Dopamine Research

Keywords

Human A30P Dopamine Storage Capacity Putamen Dopamine Central Nervous System Application 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Déglon N, Tseng JL, Bensadoun JC, Zurn AD, Arsenijevic Y, Pereira de Almeida L, Zufferey R, Trono D, Aebischer P (2000) Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease. Hum Gene Ther 11: 179–190PubMedCrossRefGoogle Scholar
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  6. Lo Bianco C, Ridet JL, Schneider BL, Deglon N, Aebischer P (2002) alpha-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease. Proc Natl Acad Sci USA 99: 10813–10818PubMedCrossRefGoogle Scholar
  7. Lo Bianco C, Deglon N, Pralong W, Aebischer P (2004a) Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease. Neurobiol Dis 17: 283–289CrossRefGoogle Scholar
  8. Lo Bianco C, Schneider BL, Bauer M, Sajadi A, Brice A, Iwatsubo T, Aebischer P (2004b) Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease. Proc Natl Acad Sci USA 101: 17510–17515CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Jean-Charles Bensadoun
  • Patrick Aebischer

There are no affiliations available

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