Empowering the impaired astrocytes in the tripartite synapses to improve accuracy of pattern recognition
- 14 Downloads
Recent finding has demonstrated that glial cells and especially astrocytes are responsible for some important roles in the central nervous system. Laboratory examination of the roles of astrocytes in information processing of neural system is associated with technical difficulties. Therefore, computational modeling provides a suitable approach in describing cognitive phenomena and neuroscience. In this paper, the role of strong and weak astrocytes in pattern recognition has considered and bio-stimulator was used to compensate the malfunction of the weak astrocyte. Therefore, we designed the tripartite synapses network, which astrocytes dominate the synaptic spaces. Then, the network has been trained on MNIST dataset. After that, the control feedback of astrocyte to pre- and postsynaptic neurons has decreased so that the astrocyte dominance on synaptic transitions decreased and impaired tripartite synapses network has been configured. In the next step, due to the destructive effects of impaired astrocyte, based on the dynamical model of the astrocyte biophysical model, a bio-inspired stimulator was designed. Accordingly, a new concept “Stimulating the impaired astrocytes to compensate their malfunction in pattern recognition” was introduced. This new mechanism was proposed to stimulate the impaired astrocytes in a population of tripartite synapses for restoration of the normal neural oscillations. Reported results confirmed that the increased error of “always firing” in pattern recognition caused by astrocytes dysfunction could be compensated by the bio-inspired stimulator.
KeywordsTripartite synapses network Impaired and strong astrocyte Bio-inspired stimulator Pattern recognition
Compliance with ethical standards
Conflict of interest
We do not have any conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
Informed consent was obtained from all individual participants included in the study.
- Jeon S, Nam Y, Cho S (2009) A neural recording and stimulation technique using passivated electrodes and micro-inductors. In: IEEE Asian solid-state circuits conference, 2009Google Scholar
- Lewis S (2015) Nanoscale neuronal activation. Nat Rev Neurosci 16(5):247Google Scholar
- Montaseri G, Yazdanpanah MJ, Amiri M (2011) Astrocyte-inspired controller design for desynchronization of two coupled limit-cycle oscillators. 2011 third world congress on nature and biologically inspired computingGoogle Scholar
- Ooyen AV, Zagolla V, Ulrich C, Schnakenberg U (2009) Pulse-clamp technique for single neuron stimulation electrode characterization. In: Annual international conference of the IEEE engineering in medicine and biology society, 2009Google Scholar
- Perea G, Yang A, Boyden ES, Sur M (2014) Optogenetic astrocyte activation modulates response selectivity of visual cortex neurons in vivo. Nat Commun 5(1)Google Scholar