Advertisement

International Journal of Biometeorology

, Volume 58, Issue 6, pp 1295–1303 | Cite as

The effect of solar-geomagnetic activity during and after admission on survival in patients with acute coronary syndromes

  • Jone VenclovieneEmail author
  • Ruta Babarskiene
  • Irena Milvidaite
  • Raimondas Kubilius
  • Jolanta Stasionyte
Original Paper

Abstract

A number of studies have established the effects of solar-geomagnetic activity on the human cardio-vascular system. It is plausible that the heliophysical conditions existing during and after hospital admission may affect survival in patients with acute coronary syndromes (ACS). We analyzed data from 1,413 ACS patients who were admitted to the Hospital of Kaunas University of Medicine, Lithuania, and who survived for more than 4 days. We evaluated the associations between active-stormy geomagnetic activity (GMA), solar proton events (SPE), and solar flares (SF) that occurred 0–3 days before and after admission, and 2-year survival, based on Cox’s proportional-hazards model, controlling for clinical data. After adjustment for clinical variables, active-stormy GMA on the 2nd day after admission was associated with an increased (by 1.58 times) hazard ratio (HR) of cardiovascular death (HR = 1.58, 95 % CI 1.07–2.32). For women, geomagnetic storm (GS) 2 days after SPE occurred 1 day after admission increased the HR by 3.91 times (HR = 3.91, 95 % CI 1.31–11.7); active-stormy GMA during the 2nd–3rd day after admission increased the HR by over 2.5 times (HR = 2.66, 95 % CI 1.40–5.03). In patients aged over 70 years, GS occurring 1 day before or 2 days after admission, increased the HR by 2.5 times, compared to quiet days; GS in conjunction with SF on the previous day, nearly tripled the HR (HR = 3.08, 95 % CI 1.32–7.20). These findings suggest that the heliophysical conditions before or after the admission affect the hazard ratio of lethal outcome; adjusting for clinical variables, these effects were stronger for women and older patients.

Keywords

Geomagnetic activity Solar flare Solar proton event Acute coronary syndromes Survival 

Notes

Acknowledgment

We acknowledge the contribution of Kaunas University of Medicine Clinic of Cardiology in the registration of cardiovascular emergency admissions and survival times, and the formation of the computer database.

References

  1. Breus TK, Baevskii PM, Nikulina GA, Chibisov SM, Chernikova AG, Pukhlyanko MI et al (1998) Geomagnetic activity effects on humans in nonstationary extreme conditions and comparison with laboratory observations (in Russian). Biofizika 43(5):811–818Google Scholar
  2. Breus TK, Baevskii RM, Chernikova AG (2012) Effects of geomagnetic disturbances on humans functional state in space flight. J Biomed Sci Eng 5:341–355CrossRefGoogle Scholar
  3. Burch JB, Reif JS, Yost MG (1999) Geomagnetic disturbances are associated with reduced nocturnal excretion of melatonin metabolite in humans. Neurosci Lett 266:209–212CrossRefGoogle Scholar
  4. Cherry NJ (2002) Schumann resonances, a plausible biophysical mechanism for the human health effects of solar/geomagnetic activity. Nat Hazards 26(3):279–331CrossRefGoogle Scholar
  5. Chibisov SM, Breus TK, Levitin AE, Drogova GM (1995) Biological effects of planetary magnetic storms (in Russian). Biofizika 40(5):959–968Google Scholar
  6. Cornelissen G, Halberg F, Breus T, Syutkina EV, Baevsky R, Weydahl A et al (2002) Non-photic solar associations of heart rate variability and myocardial infarction. J Atmos Solar-Terr Phys 64:707–720CrossRefGoogle Scholar
  7. Cornelissen G, Halberg F, Sothern RB, Hillman DC, Siegelova J (2010) Blood presure, heart rate and melatonin cycles synchronization with the season, Earth magnetism and solar flares. Scr Med (Brno) 83(1):16–32Google Scholar
  8. Dimitrova S, Stoilova I (2003) Planetary geomagnetic indices, human physiology and subjective complaints. J Balkan Geophys Soc 6(1):37–45Google Scholar
  9. Dimitrova S, Stoilova I, Cholakov I (2004) Influence of local geomagnetic storms on arterial blood pressure. Βioelectromagnetics 25:408–414CrossRefGoogle Scholar
  10. Dimitrova S, Stoilova I, Georgieva K, Taseva T, Jordanova M, Maslarov D (2009) Solar and geomagnetic activity and acute myocardial infarction morbidity and mortality. Fundam space research. Suppl C R Acad Bulg Sci 161–165Google Scholar
  11. Dominguez-Rodriguez A, Abreu-Gonzalez P, Garcia MJ et al (2002) Decreased nocturnal melatonin levels during acute myocardial infarction. J Pineal Res 33:248–252CrossRefGoogle Scholar
  12. Dominguez-Rodriguez A, Abreu-Gonzalez P, Garcia-Gonzalez MJ, Reiter RJ (2007) Relation of nocturnal melatonin levels to serum matrix metalloproteinase-9 concentrations in patients with myocardial infarction. Thromb Res 120:361–366CrossRefGoogle Scholar
  13. Dominguez-Rodriguez A, Abreu-Gonzalez P, Sanchez-Sanchez J, Kaski J, Reiter R (2010) Melatonin and circadian biology in human cardiovascular disease. J Pineal Res 49:14–22Google Scholar
  14. Dorman LI, Ptitsyna NG, Villoresi G, Kasinsky VV, Lyakhov NN, Tyasto MI (2008) Space storms as natural hazards. Adv Geosci 14:271–275CrossRefGoogle Scholar
  15. Durgan DJ, Hotze MA, Tomlin TM et al (2005) The intrinsic circadian clock within the cardiomyocyte. Am J Physiol Heart Circ Physiol 289:H1530–H1541CrossRefGoogle Scholar
  16. Ghione S, Mezzasalma L, Del Seppia C, Papi F (1998) Do geomagnetic disturbances of solar origin affect arterial blood pressure? J Hum Hypertens 12(11):749–754CrossRefGoogle Scholar
  17. Gurfinkel II, Liubimov VV, Oraevskii VN, Parfenova LM, Iur'ev AS (1995) The effect of geomagnetic disturbances in capillary blood flow in ischemic heart disease patients (in Russian). Biofizika 40(4):793–799Google Scholar
  18. Gurfinkel II, Kuleshova VP, Oraevskii VN (1998) Assessment of the effect of a geomagnetic storm on the frequency of appearance of acute cardiovascular pathology (in Russian). Biofizika 43(4):654–658Google Scholar
  19. Mendoza B, Diaz-Sandoval R (2000) Relationship between solar activity and myocardial infarctions in Mexico City. Geofís Int 39(1):1–4Google Scholar
  20. Mendoza B, Diaz-Sandoval R (2004) Effects of solar activity on myocardial infarction death in low geomagnetic latitude regions. Nat Hazards 32(1):35–36CrossRefGoogle Scholar
  21. Oraevskiĭ VN, Breus TK, Baevskiĭ RM, Rapoport SI, Petrov VM, Barsukova ZHV et al (1998) Effect of geomagnetic activity on the functional status of the body (in Russian). Biofizika 43(5):819–826Google Scholar
  22. Palmer S, Rycroft M, Cermack M (2006) Solar and geomagnetic activity, extremely low frequency magnetic and electric fields and human health at the Earth’s surface. Surv Geogphys 27:557–595CrossRefGoogle Scholar
  23. Pikin DA, Gurgfinkel II, Oraevskii VN (1998) Effect of geomagnetic disturbances on the blood coagulation system in patients with ischemic heart disease and prospects for correction medication (in Russian). Biofizika 43(4):617–622Google Scholar
  24. Raps A, Stoupel E, Shimshoni M (1992) Geophysical variables and behavior: LXIX. Solar activity and admission of psychiatric inpatients. Percept Mot Ski 74:449–450CrossRefGoogle Scholar
  25. Sack RL, Lewy AJ, Erb DL et al (1986) Human melatonin production decreases with age. J Pineal Res 3:379–388CrossRefGoogle Scholar
  26. Stoupel E, Shimshoni M, Agmon J (1988) Is the localization of myocardial infarction time related? Clin Cardiol 11:45–49CrossRefGoogle Scholar
  27. Stoupel E, Israelevich P, Gabbay U, Abramson E, Petrauskiene J, Kalediene B et al (2000) Correlation of two levels of space proton flux with monthly distribution of deaths from cardiovascular disease and suicide. J Basic Clin Physiol Pharmacol 11(1):63–71CrossRefGoogle Scholar
  28. Stoupel E, Domarkiene S, Radishauskas R, Abramson E (2002) Sudden cardiac death and geomagnetic activity: links to age, gender and agony time. J Basic Clin Physiol Pharmacol 13(1):11–21Google Scholar
  29. Stoupel E, Domarkiene S, Radishauskas R, Israelevich P, Abramson E, Sulkes J (2005) In women myocardial infraction occurrence is much stronger related to environmental physical activity than in men—a gender or an advanced age effect? J Clin Basic Cardiol 8:59–60Google Scholar
  30. Stoupel E, Assali A, Teplitzky I, Israelevich P, Abramson E, Sulkes J, Kornowski R (2008) The culprit artery in acute myocardial infarction in different environmental physical activity levels. Int J Cardiol 126(2):288–290CrossRefGoogle Scholar
  31. Stoupel E, Assali A, Teplitzky I, Vaknin-Assa H, Abramson E, Israelevich P, Kornowski R (2009) Physical influences on right ventricular infarction and cardiogenic shock in acute myocardial infarction. J Basic Clin Physiol Pharmacol 20(1):81–87CrossRefGoogle Scholar
  32. Stoupel E, Tamoshiunas A, Radishauskas R, Bernotiene G, Abramson E, Sulkes J, Israelevich P (2010) Acute Myocardial Infarction (AMI) and Intermediate Coronary Syndrome (ICS). Health 2(2):131–136CrossRefGoogle Scholar
  33. Tengattini S, Reiter RJ, Tan DX et al (2008) Cardiovascular diseases: protective effects of melatonin. J Pineal Res 44:16–25Google Scholar
  34. Van De Werf F, Bax J, Betriu A et al (2008) Management of acute myocardial infarction in patients presenting with persistent ST segment elevation. Eur Heart J 23(9):2909–2945Google Scholar
  35. Vencloviene J, Babarskiene R, Slapikas R (2013) The association between solar particle events, geomagnetic storms, and hospital admissions for myocardial infarction. Nat Hazards 65(1):1–12CrossRefGoogle Scholar
  36. Villoresi G, Ptitsyna NG, Tiasto MI, Iucci N (1998) Myocardial infarct and geomagnetic disturbances: analysis of data on morbidity and mortality (in Russian). Biofizika 43(4):623–632Google Scholar
  37. Watanabe Y, Cornélissen G, Halberg F, Otsuka K, Ohkawa SI (2001) Associations by signatures and coherences between the human circulation and helio- and geomagnetic activity. Biomed Pharmacother 55(1):76–83Google Scholar
  38. Weydahl A, Sothern RB, Cornélissen G, Wetterburg L (2001) Geomagnetic activity influences the melatonin secretion at 70 degrees. Biomed Pharmacother 55(1):57–62Google Scholar
  39. Yan AT, Yan RT, Tan M et al (2007) Risk scores for risk stratification in acute coronary syndromes: useful but simpler is not necessarily better. Eur Heart J 28(9):1072–1078CrossRefGoogle Scholar
  40. Yaprak M, Altun A, Vardar A et al (2003) Decreased nocturnal synthesis of melatonin in patients with coronary artery disease. Int J Cardiol 89:103–107CrossRefGoogle Scholar
  41. Zenchenko T, Poskotinova LV, Rekhtina AG, Zaslavskaya RM (2010) Relation between microcirculation parameters and Pc3 geomagnetic pulsations. Biophysics 55(4):646–651CrossRefGoogle Scholar

Copyright information

© ISB 2013

Authors and Affiliations

  • Jone Vencloviene
    • 1
    Email author
  • Ruta Babarskiene
    • 2
  • Irena Milvidaite
    • 3
  • Raimondas Kubilius
    • 2
  • Jolanta Stasionyte
    • 4
  1. 1.Institute of CardiologyVytautas Magnus UniversityKaunasLithuania
  2. 2.Department of CardiologyLithuanian University of Health SciencesKaunasLithuania
  3. 3.Institute of Cardiology, Lithuanian University of Health SciencesKaunasLithuania
  4. 4.Department of Environmental SciencesVytautas Magnus UniversityKaunasLithuania

Personalised recommendations