Advertisement

International Journal of Biometeorology

, Volume 54, Issue 3, pp 249–254 | Cite as

The effect of balneotherapy on C-reactive protein, serum cholesterol, triglyceride, total antioxidant status and HSP-60 levels

  • Mihály Oláh
  • Ágnes Koncz
  • Judit Fehér
  • Judit Kálmánczhey
  • Csaba Oláh
  • Sándor Balogh
  • György Nagy
  • Tamás BenderEmail author
Original Paper

Abstract

An increasing body of evidence substantiating the effectiveness of balneotherapy has accumulated during recent decades. In the present study, 42 ambulatory patients (23 males and 19 females, mean age 59.5 years) with degenerative musculoskeletal disease were randomised into one of two groups—bathing in tap water or in mineral water at the same temperature—and subjected to 30-min balneotherapy sessions on 15 occasions. Study parameters comprised serum levels of sensitised C-reactive protein (CRP), plasma lipids, heat shock protein (HSP-60) and total antioxidant status (TAS). In both groups, CRP levels followed a decreasing tendency, which still persisted 3 months later. At 3 months after balneotherapy, serum cholesterol levels were still decreasing in patients who had used medicinal water, but exhibited a trend towards an increase in the control group. Triglyceride levels followed a decreasing trend in both patient groups. TAS showed a declining tendency in both groups. No changes of HSP-60 levels were observed in either group. Balneotherapy with the thermal water from Hajdúszoboszló spa had a more pronounced physiological effect compared to that seen in the control group treated with tap water in a 3 month period.

Keywords

Balneotherapy Atherosclerosis C-reactive protein 

Notes

Acknowledgement

The authors thank András Németh for performing the statistical analysis.

References

  1. Benagiano M, D'Elios MM, Amedei A, Azzurri A, van der Zee R, Ciervo A, Rombolà G, Romagnani S, Cassone A, Del Prete G (2005) Human 60-kDa heat shock protein is a target autoantigen of T cells derived from atherosclerotic plaques. J Immunol 174:6509–6517PubMedGoogle Scholar
  2. Bender T, Karagulle Z, Balint GP, Gutenbrunner C, Balint PV, Sukenik S (2005) Hydrotherapy, balneotherapy, and spa treatment in pain management. Rheumatol Int 25:220–224CrossRefPubMedGoogle Scholar
  3. Burke AP, Tracy RP, Kolodgie F, Malcom GT, Zieske A, Kutys R, Pestaner J, Smialek J, Virmani R (2002) Elevated C-reactive protein values and atherosclerosis in sudden coronary death: association with different pathologies. Circulation 105:2019–2023CrossRefPubMedGoogle Scholar
  4. Cider A, Sveälv BG, Täng MS, Schaufelberger M, Andersson B (2006) Immersion in warm water induces improvement in cardiac function in patients with chronic heart failure. Eur J Heart Fail 8:308–313CrossRefPubMedGoogle Scholar
  5. Fujimoto S, Hartung D, Ohshima S, Edwards DS, Zhou J, Yalamanchili P, Azure M, Fujimoto A, Isobe S, Matsumoto Y, Boersma H, Wong N, Yamazaki J, Narula N, Petrov A, Narula J (2008) Molecular imaging of matrix metalloproteinase in atherosclerotic lesions: resolution with dietary modification and statin therapy. J Am Coll Cardiol 52:1847–1857CrossRefPubMedGoogle Scholar
  6. Greenwood J, Mason JC (2007) Statins and the vascular endothelial inflammatory response. Trends Immunol 28:88–98CrossRefPubMedGoogle Scholar
  7. Kamioka H, Nakamura Y, Yazaki T, Uebaba K, Mutoh Y, Okada S, Takahashi M (2006) Comprehensive health education combining hot spa bathing and lifestyle education in middle-aged and elderly women: one-year follow-up on randomized controlled trial of three- and six-month interventions. J Epidemiol 16:35–44CrossRefPubMedGoogle Scholar
  8. Kubota K, Kurabayashi H, Tamura K, Kawada E, Tamura J, Shirakura T (1992) A transient rise in plasma beta-endorphin after a traditional 47 degrees C hot-spring bath in Kusatsu-spa, Japan. Life Sci 51:1877–1880CrossRefPubMedGoogle Scholar
  9. Matz H, Orion E, Wolf R (2003) Balneotherapy in dermatology. Dermatol Therapy 16:132–140CrossRefGoogle Scholar
  10. Miller NJ, Rice-Evans C, Davies MJ, Gopinathan V, Milner A (1993) A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clin Sci (Lond) 84:407–412Google Scholar
  11. Mitchell RS, Kumar V, Abbas AK, Fausto N (2007) Robbins Basic Pathology: With Student Consult, Online Access, 8th edn. Saunders, Philadelphia, p 345Google Scholar
  12. Nakashima Y, Raines EW, Plump AS, Breslow JL, Ross R (1998) Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the ApoE-deficient mouse. Arterioscler Thromb Vasc Biol 18:842–851PubMedGoogle Scholar
  13. Nasermoadelli A, Kagamimori S (2006) Balneotherapy in medicine—a review. Environ Health Prev Med 10:171–179CrossRefGoogle Scholar
  14. Ohtsuka, Yabunaka N, Watanabe I, Noro H, Agishi Y (1996) Balneotherapy and platelet glutathione metabolism in type II diabetic patients. Int J Biometeorol 39:156–159Google Scholar
  15. Schmid JP, Noveanu M, Morger C, Gaillet R, Capoferri M, Anderegg M, Saner H (2007) Influence of water immersion, water gymnastics and swimming on cardiac output in patients with heart failure. Heart 93:722–727CrossRefPubMedGoogle Scholar
  16. Schunkert H, Samani NJ (2008) Elevated C-reactive protein in atherosclerosis—chicken or egg? New Engl J Med 359:953–1955CrossRefGoogle Scholar
  17. Shamaei-Tousi A, Stephens JW, Bin R, Cooper JA, Steptoe A, Coates AR, Henderson B, Humphries SE (2006) Association between plasma levels of heat shock protein 60 and cardiovascular disease in patients with diabetes mellitus. Eur Heart J 27:1565–1570CrossRefPubMedGoogle Scholar
  18. Sramek P, Simeckova M, Jansky L, Savlikova J, Vybiral S (2000) Human physiological responses to immersion into water of different temperatures. Eur J Appl Physiol 81:436–442CrossRefPubMedGoogle Scholar
  19. Strauss-Blasche G, Ekmekcioglu C, Leibetseder V, Marktl W (2003) Seasonal variation of lipid-lowering effects of complex spa therapy. Forsch Komplementarmed Klass Naturheilkd 10:78–84CrossRefPubMedGoogle Scholar
  20. Sukenik S, Flusser D, Abu-Shakra M (1999) The role of spa therapy in various rheumatic diseases. Rheum Dis Clin North Am 25:883–897CrossRefPubMedGoogle Scholar
  21. Turesson C, Jacobsson LT, Matteson EL (2008) Cardiovascular co-morbidity in rheumatic diseases. Vasc Health Risk Manag 4:605–614PubMedGoogle Scholar
  22. Yamaoka K, Mitsunobu F, Hanamoto K, Shibuya K, Mori S, Tanizaki Y, Sugita K (2004) Biochemical comparison between radon effects and thermal effects on humans in radon hot spring therapy. J Radiat Res (Tokyo) 45:83–88CrossRefGoogle Scholar

Copyright information

© ISB 2009

Authors and Affiliations

  • Mihály Oláh
    • 1
  • Ágnes Koncz
    • 5
  • Judit Fehér
    • 1
  • Judit Kálmánczhey
    • 1
  • Csaba Oláh
    • 2
  • Sándor Balogh
    • 4
  • György Nagy
    • 3
  • Tamás Bender
    • 3
    • 6
    Email author
  1. 1.Hungarospa HajdúszoboszlóHajdúszoboszlóHungary
  2. 2.Department of NeurosurgeryBAZ County HospitalMiskolcHungary
  3. 3.Polyclinic, Hospital of the Hospitaller Brothers of St. John of GodBudapestHungary
  4. 4.National Institute of Primary Health CareUniversity of SzegedSzegedHungary
  5. 5.‘Heim Pál’ Paediatric HospitalBudapestHungary
  6. 6.Budai Irgalmasrendi KórházBudapestHungary

Personalised recommendations