Advertisement

Der Schmerz

, Volume 30, Issue 6, pp 526–536 | Cite as

Stressinduzierte Hyperalgesie (SIH) als Folge von emotionaler Deprivation und psychischer Traumatisierung in der Kindheit

Konsequenzen für die Schmerztherapie
  • U. T. EgleEmail author
  • N. Egloff
  • R. von Känel
Review

Zusammenfassung

Die Schmerzforschung der letzten Jahre hat gezeigt, dass bei vielen chronischen Schmerzstörungen Ausmaß und Stärke des individuell erlebten Schmerzes nicht mit dem Ausmaß der peripheren Gewebeschädigung oder der Aktivität der primär-afferenten und der spinal-nozizeptiven neuronalen Bahnen korrelieren. Insbesondere Stress und Angst üben einen modulierenden Einfluss auf das Schmerzerleben aus, wobei Art, Dauer und Schwere des Stressors sowie biographisch frühe Prägungen bei der Ausreifung des Stress- wie des Schmerzverarbeitungssystems bedeutsam sind. Bei einigen chronischen Schmerzstörungen, z. B. Fibromyalgiesyndrom, craniomandibuläre Dysfunktion (CMD) oder somatoforme Schmerzstörung, ist kein relevanter peripherer Input nachweisbar. Die Arbeit gibt einen Überblick über Studien, welche tierexperimentell ebenso wie beim Menschen die neurobiologischen Mechanismen und neuronalen Botenstoffe bei der stressinduzierten Hyperalgesie untersuchen. Daraus werden Konsequenzen für die aktuelle wie künftige Schmerztherapie abgeleitet.

Schlüsselwörter

Stressinduzierte Hyperalgesie Kindheitstraumatisierung Bindung Fibromyalgiesyndrom Somatoforme Schmerzstörung 

Stress-induced hyperalgesia (SIH) as a consequence of emotional deprivation and psychosocial traumatization in childhood

Implications for the treatment of chronic pain

Abstract

It is now widely recognized that in many chronic pain syndromes the intensity and severity of individually perceived pain does not correlate consistently with the degree of peripheral nervous system tissue damage or with the intensity of primary afferent or spinal nociceptive neurone activity. In particular, stress and anxiety exert modulatory influences on pain depending on the nature, duration and intensity of the stressor and developmental influences on the maturation of the stress as well as the pain system. In some chronic pain syndromes, e. g. fibromyalgia, TMD or somatoform disorders, no nociceptive or neuropathic input is detectable. We summarise the studies investigating the neural substrates and neurobiological mechanisms of stress-induced hyperalgesia (SIH) in animals and humans. The review provides new perspectives and challenges for the current and future treatment of chronic pain.

Keywords

Stress induced hyperalgesia Childhood traumatization Attachment Fibromyalgia Somatoform pain disorder 

Notes

Einhaltung ethischer Richtlinien

Interessenkonflikt

Die Autoren geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

Literatur

  1. 1.
    Adler RH, Zlot S, Hürny C, Minder C (1989) Engel’s „psychogener Schmerz und der zu Schmerz neigende Patient“: Eine retrospektive, kontrollierte klinische Studie. Psychother Psychosom Med Psychol 39:209–218PubMedGoogle Scholar
  2. 2.
    Afari N, Ahumada SM, Wright LJ, Mostoufi S, Golnari G, Reis V, Cuneo JG (2014) Psychological trauma and functional somatic syndromes: A systematic review and meta-analysis. Psychosom Med 76:2–11PubMedCrossRefGoogle Scholar
  3. 3.
    Alvarez P, Green PG, Levine JD (2013) Stress in the adult rat exacerbates muscle pain induced by early life stress. Biol Psychiatry 74:688–695PubMedPubMedCentralCrossRefGoogle Scholar
  4. 4.
    Arnold B, Brinkschmidt T, Casser HR, Diezemann A, Gralow I, Irnich D, Kaiser U, Klasen B, Klimczyk K, Lutz J, Nagel B, Pfingsten M, Sabatowski R, Schesser R, Schiltenwolf M, Seeger D, Söllner W (2014) Multimodale Schmerztherapie für die Behandlung chronischer Schmerzsyndrome. Ein Konsensuspapier der Ad-hoc-Kommission Multimodale interdisziplinäre Schmerztherapie der Deutschen Schmerzgesellschaft zu den Behandlungsinhalten. Schmerz 28(5):459–472PubMedCrossRefGoogle Scholar
  5. 5.
    AWMF Langzeitanwendung von Opioiden bei nicht tumorbedingten Schmerzen (LONTS). http://www.awmf.org/uploads/tx_szleitlinien/145-003l_S3_LONTS_2015-01.pdf
  6. 6.
    Bär KJ, Brehm S, Boettger MK, Boettger S, Wagner G, Sauer H (2005) Pain perception in major depression depends on pain modality. Pain 17(1–2):97–103CrossRefGoogle Scholar
  7. 7.
    Basbaum AI, Fields HL (1984) Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci 7:309–338PubMedCrossRefGoogle Scholar
  8. 8.
    Benedetti F, Amanzio M, Vighetti S, Asteggiano G (2006) The biochemical and neuroendocrine bases of the hyperalgesic nocebo effect. J Neurosci 26(46):12014–12022PubMedCrossRefGoogle Scholar
  9. 9.
    Bernardy K, Füber N, Köllner V, Häuser W (2010) Efficacy of cognitive-behavioral therapies in fibromyalgia syndrome. A systematic review and metaanalysis of randomized controlled trials. J Rheumatol 37:1991–2005PubMedCrossRefGoogle Scholar
  10. 10.
    Bernardy K, Klose P, Busch AJ, Choy EH, Häuser W (2013) Cognitive behavioural therapies for fibromyalgia. Cochrane Database Syst Rev 9:CD009796Google Scholar
  11. 11.
    Blumenstiel K, Gerhardt A, Rolke R, Bieber C, Tesarz J, Friederich HC, Eich W, Treede RD (2011) Quantitative sensory testing profiles in chronic back pain are distinct from those in fibromyalgia. Clin J Pain 27(8):682–690PubMedCrossRefGoogle Scholar
  12. 12.
    Bondo Lind A, Delmar C, Nielsen KK (2014) Struggling in an emotional avoidance culture: A qualitative study of stress as a predisposing factor for somatoform disorders. J Psychosom Res 76:94–98CrossRefGoogle Scholar
  13. 13.
    Bowers ME, Choi DC, Ressler KJ (2012) Neuropeptide regulation of fear and anxiety: implications of cholecystokinin, endogenous opioids and neuropeptide. Physiol Behav 107:699–710PubMedPubMedCentralCrossRefGoogle Scholar
  14. 14.
    Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D (2006) Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain 10:287–333PubMedCrossRefGoogle Scholar
  15. 15.
    Brown J, Berenson K, Cohen P (2005) Documented and self-reported child abuse and adult pain in a community sample. Clin J Pain 21:374–377PubMedCrossRefGoogle Scholar
  16. 16.
    Buhle JT, Kober H, Ochsner KN, Mende-Siedlecki P, Weber J, Hughes BL, Kross E, Atlas LY, McRae K, Wager TD (2013) Common representation of pain and negative emotion in the midbrain periaqueductal gray. Soc Cogn Affect Neurosci 8:609–616PubMedCrossRefGoogle Scholar
  17. 17.
    Bushnell MC, Ceko M, Low LA (2013) Cognitive and emotional control of pain and its disruption in chronic pain. Nat Rev Neurosci 14:5012–5011CrossRefGoogle Scholar
  18. 18.
    Butler RK, Finn PD (2009) Stress-induced analgesia. Prog Neurobiol 88:184–202PubMedCrossRefGoogle Scholar
  19. 19.
    Cairns BE (2010) Pathophysiology of TMD pain – basic mechanisms and their implications for pharmacotherapy. J Oral Rehabil 37(6):391–410PubMedCrossRefGoogle Scholar
  20. 20.
    Ciechanowski P, Sullivan M, Jensen M, Romano J, Summers H (2003) The relationship of attachment style to depression, catastrophizing and health care utilization in patients with chronic pain. Pain 104:627–637PubMedCrossRefGoogle Scholar
  21. 21.
    Cierpka M (2015) Psychosoziale Prävention – ein Mehrebenenansatz. In: Egle UT, Joraschky P, Lampe A, Seiffge-Krenke I, Cierpka M (Hrsg) Sexueller Missbrauch, Misshandlung, Vernachlässigung. Erkennung, Therapie und Prävention der Folgen früher Stresserfahrungen. Schattauer, Stuttgart, S 677–696Google Scholar
  22. 22.
    Crettaz B, Marziniak M, Willeke P, Young P, Hellhammer D, Stumpf A, Burgmer M (2013) Stress-induced allodynia – evidence of increased pain sensitivity in healthy humans andpatients with chronic pain after experimentally induced psychosocial stress. PLOS ONE 8(8):e69460PubMedPubMedCentralCrossRefGoogle Scholar
  23. 23.
    Cuthbert BN, Insel TR (2013) Toward the future of psychiatric diagnosis: the seven pillars of RDoC. BMC Med 14(11):126CrossRefGoogle Scholar
  24. 24.
    Davis DA, Luecken LJ, Zautra AJ (2005) Are reports of childhood abuse related to the experience of chronic pain in adulthood? A meta-analytic review of the literature. Clin J Pain 21:398–405PubMedCrossRefGoogle Scholar
  25. 25.
    Dedovic K, Duchesne A, Andrews J, Engert V, Pruessner JC (2009) The brain and the stress axis: the neural correlates of cortisol regulation in response to stress. Neuroimage 47:864–871PubMedCrossRefGoogle Scholar
  26. 26.
    Derbyshire SW, Whalley MG, Stenger VA, Oakley DA (2004) Cerebral activation during hypnotically induced and imagined pain. Neuroimage 23:392–401PubMedCrossRefGoogle Scholar
  27. 27.
    Eatough EM, Waya JD, Chang C‑H (2012) Understanding the link between psychosocial work stressors and work-related musculoskeletal complaints. Appl Ergon 43:554–563PubMedCrossRefGoogle Scholar
  28. 28.
    Eccleston C, Williams AC, Morley S (2009) Psychological therapies for the management of chronic pain (excluding headache) in adults (Review). Cochrane Database Syst Rev 2:CD007407 doi:10.1002/14651858Google Scholar
  29. 29.
    Egle UT (2015) Gesundheitliche Langzeitfolgen psychisch traumatisierender und emotional deprivierender Entwicklungsbedingungen in Kindheit und Jugend. In: Egle UT, Joraschky P, Lampe A, Seiffge-Krenke I, Cierpka M (Hrsg) Sexueller Missbrauch, Misshandlung, Vernachlässigung. Erkennung, Therapie und Prävention der Folgen früher Stresserfahrungen. Schattauer, Stuttgart, S 24–39Google Scholar
  30. 30.
    Egle UT, Ecker-Egle ML, Nickel R, van Houdenhove B (2004) Störung der zentralen Schmerz- und Stressverarbeitung bei Fibromyalgie. Ein neues biopsychosoziales Pathogenese-Modell. Psychother Psychosom Med Psychol 54:137–147PubMedCrossRefGoogle Scholar
  31. 31.
    Egle UT, Ecker-Egle M‑L, Nickel R (2011) Fibromyalgie-Syndrom – eine Stressverarbeitungsstörung. Schweiz Arch Neurol Psychiatr 162:326–337Google Scholar
  32. 32.
    Egle UT, Frommberger U, Kappis B (2014) Begutachtung bei Posttraumatischer Belastungsstörung mit Leitsymptom Schmerz. Schmerz 28:354–364PubMedCrossRefGoogle Scholar
  33. 33.
    Egle UT, Kissinger D, Schwab R (1991) Eltern-Kind-Beziehung als Prädisposition für ein psychogenes Schmerzsyndrom im Erwachsenenalter. Eine kontrollierte, retrospektive Studie zu G. L. Engels „pain-proneness“. Psychother Psychosom Med Psychol 41:247–256PubMedGoogle Scholar
  34. 34.
    Egle UT, Nickel R (1998) Kindheitsbelastungsfaktoren bei Patienten mit somatoformen Störungen. Z Psychosom Med 44:21–36Google Scholar
  35. 35.
    Egle UT, Nickel R (2016) Fibromyalgie-Syndrom. In: Herzog W, Joraschky P, Köhle K, Langewitz W, Söllner W (Hrsg) Uexküll Psychosomatische Medizin. Elsevier, Urban u. Vogel, München (im Druck)Google Scholar
  36. 36.
    Egloff N, Cámara R, von Känel R, Klingler N, Marti E, Gander FML (2014) Hypersensitivity and hyperalgesia in somatoform pain disorders. Gen Hosp Psychiatry 36:284–290PubMedCrossRefGoogle Scholar
  37. 37.
    Egloff N, Egle UT, von Känel R (2008) Weder Descartes noch Freud? Aktuelle Schmerzmodelle in der Psychosomatik. Praxis 97:549–557PubMedCrossRefGoogle Scholar
  38. 38.
    Egloff N, Hirschi A, von Känel R (2013) Traumatization and chronic pain: a further model of interaction. J Pain Res 6:765–770PubMedPubMedCentralCrossRefGoogle Scholar
  39. 39.
    Eisenberger N (2012) The pain of social disconnection: examining the shared neural underpinnings of physical and social pain. Nat Rev Neurosci 13:421–434PubMedCrossRefGoogle Scholar
  40. 40.
    Eisenberger NI, Master SL, Inagaki TK, Taylor SE, Shirinyan D, Lieberman MD, Naliboff BD (2011) Attachment figures activate a safety signal-related neural region and reduce pain experience. Proc Natl Acad Sci USA 108:11721–11726PubMedPubMedCentralCrossRefGoogle Scholar
  41. 41.
    Engel GL (1959) „Psychogenic“ pain and the pain-prone patient. Am J Med 26:899–918PubMedCrossRefGoogle Scholar
  42. 42.
    Fillingim RB, Ohrbach R, Greenspan JD, Knott C, Diatchenko L, Dubner R, Bair E, Baraian C, Mack N, Slade GD, Maixner W (2013) Psychological factors associated with development of TMD: the OPPERA prospective cohort study. J Pain 14(12 Suppl):T75–90PubMedCrossRefGoogle Scholar
  43. 43.
    Glaros AG, Williams K, Lausten L (2005) The role of parafunctions, emotions and stress in predicting facial pain. J Am Dent Assoc 136(4):451–458PubMedCrossRefGoogle Scholar
  44. 44.
    Glombiewski JA, Tersek J, Rief W (2008) Muscular reactivity and specifity in chronic back pain patients. Psychosom Med 70:125–131PubMedCrossRefGoogle Scholar
  45. 45.
    Green PG, Alvarez P, Gear RW, Mendoza D, Levine JD (2011) Further validation of a model of fibromyalgia syndrome in the rat. J Pain 12:811–818PubMedPubMedCentralCrossRefGoogle Scholar
  46. 46.
    Green PG, Chen X, Alvarez P, Levine JD, Ferrari LF (2011) Early-life stress produces muscle hyperalgesia and nociceptor sensitization in the adult rat. Pain 152:2549–2556PubMedPubMedCentralCrossRefGoogle Scholar
  47. 47.
    Guillemin R, Ling N, Burgus R, Bloom F, Segal D (1977) Characterization of the endorphins, novel hypothalamic and neurohypophysial peptides with opiate-like activity: evidence that they induce profound behavioral changes. Psychoneuroendocrinology 2:59–62PubMedCrossRefGoogle Scholar
  48. 48.
    Gündel H, Valet M, Sorg C, Huber D, Zimmer C, Sprenger T, Tölle TR (2008) Altered cerebral response to noxious heat stimulation in patients with somatoform pain disorder. Pain 137:413–421PubMedCrossRefGoogle Scholar
  49. 49.
    Hardt J, Rutter M (2004) Validity of adult retrospective reports of adverse childhood experiences: review of the evidence. J Child Psychol Psychiatry 45:260–273PubMedCrossRefGoogle Scholar
  50. 50.
    Hardt J, Sidor A, Bracko M, Egle UT (2006) Reliability of retrospective assessments of childhood experiences in Germany. J Nerv Ment Dis 194:676–683PubMedCrossRefGoogle Scholar
  51. 51.
    Häuser W, Marschall U, L’hoest H, Komossa K, Henningsen P (2013) Administrative Prävalenz, Behandlung und Krankheitskosten der somatoformen Schmerzstörung Analyse von Daten der BARMER GEK für die Jahre 2008–2010. Schmerz 27:380–386PubMedCrossRefGoogle Scholar
  52. 52.
    Heinrichs M, von Dawans B, Domes G (2009) Oxytocin, vasopressin, and human social behavior. Front Neuroendocrinol 30:548–557PubMedCrossRefGoogle Scholar
  53. 53.
    Hughes J, Smith TW, Kosterlitz HW, Fothergill LA, Morgan BA, Morris HR (1975) Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature 258(5536):577–580PubMedCrossRefGoogle Scholar
  54. 54.
    Imbe H, Iwai-Liao Y, Senba E (2006) Stress-induced hyperalgesia: animal models and putative mechanisms. Front Biosci 11:2179–2192PubMedCrossRefGoogle Scholar
  55. 55.
    Imbierowicz K, Egle UT (2003) Childhood adversities in patients with fibromyalgia and somatoform pain disorder. Eur J Pain 7:113–119PubMedCrossRefGoogle Scholar
  56. 56.
    Insel T, Cuthbert B, Garvey M, Heinssen R, Pine DS, Quinn K, Sanislow C, Wang P (2010) Research domain criteria (RDoC): toward a new classification framework for research on mental disorders. Am J Psychiatry 167:748–751PubMedCrossRefGoogle Scholar
  57. 57.
    Ip HYV, Abrishami A, Peng PWH, Wong J, Chung F (2009) Predictors of postoperative pain and analgesic consumption: a qualitative systematic review. Anesthesiology 111:657–677PubMedCrossRefGoogle Scholar
  58. 58.
    Jennings EM, Okine BN, Roche M, Finn DP (2014) Stress-induced hyperalgesia. Prog Neurobiol 121:1–18PubMedCrossRefGoogle Scholar
  59. 59.
    Jensen KB, Srinivasan P, Spaeth R, Tan Y, Kosek E, Petzke F, Carville S, Fransson P, Hanke M, Williams SCR, Choy E, Vitton O, Gracely R, Ingvar M, Kong J, Steven CR (2013) Overlapping structural and functional brain changes in patients with long-term exposure to fibromyalgia pain. Arthritis Rheum 65:3293–3303PubMedPubMedCentralCrossRefGoogle Scholar
  60. 60.
    Kaiser U, Nilges P (2015) Behavioral concepts in the treatment of chronic pain. Schmerz 29:179–185PubMedCrossRefGoogle Scholar
  61. 61.
    Khan et al (2015) Childhood maltreatment, depression, and suicidal ideation: critical importance of parental and peer emotional abuse during developmental sensitive periods in males and females. Front Psychiatry 6:42 doi:10.3389/fpsyt.2015.00042PubMedPubMedCentralGoogle Scholar
  62. 62.
    Kivimäki M, Leino-Arias P, Virtanen M, Elovainio M, Keltikangas-Järvinen L, Puttonen S, Vartia M, Brunner E, Vahtera J (2004) Work stress and incidence of newly diagnosed fibromyalgia: prospective cohort study. J Psychosom Res 57:417–422PubMedGoogle Scholar
  63. 63.
    Knaster P, Karlsson H, Estlander AM, Eija Kalso E (2012) Psychiatric disorders as assessed with SCID in chronic pain patients: the anxiety disorders precede the onset of pain. Gen Hosp Psychiatry 34:46–52Google Scholar
  64. 64.
    Lampe A, Söllner W (2015) Pelvipathie bei Frauen. In: Egle UT, Joraschky P, Lampe A, Seiffge-Krenke I, Cierpka M (Hrsg) Sexueller Missbrauch, Misshandlung, Vernachlässigung. Erkennung, Therapie und Prävention der Folgen früher Stresserfahrungen. Schattauer, Stuttgart, S 424–440Google Scholar
  65. 65.
    Lidow MS (2002) Long-term effects of neonatal pain on nociceptive systems. Pain 99:377–383PubMedCrossRefGoogle Scholar
  66. 66.
    Lovick TA (2008) Pro-nociceptive action of cholecystokinin in the periaqueductal grey: a role in neuropathic and anxiety-induced hyperalgesic states. Neurosci Biobehav Rev 32:852–862PubMedCrossRefGoogle Scholar
  67. 67.
    Lupien SJ, McEwen BS, Gunnar MR, Heim C (2009) Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat Neurosci Rev 10:434–445CrossRefGoogle Scholar
  68. 68.
    MacDonald G, Kingsbury R (2006) Does physical pain augment anxious attachment? J Soc Pers Relat 23:291–304CrossRefGoogle Scholar
  69. 69.
    Mattila AK, Kronholm E, Jula A, Salminen JK, Koivisto AM, Mielonene RL (2008) Alexithymia and somatization in general population. Psychosom Med 70:716–722PubMedCrossRefGoogle Scholar
  70. 70.
    McCall JG, Al-Hasani R, Siuda ER, Hong DY, Norris AJ, Ford CP, Bruchas MR (2015) CRH engagement of the locus ceruleus noradrenergic system mediates stress-Induced anxiety. Neuron 87:605–620PubMedPubMedCentralCrossRefGoogle Scholar
  71. 71.
    McEwen BS (1998) Protective and damaging effects of stress mediators. N Engl J Med 338:171–179PubMedCrossRefGoogle Scholar
  72. 72.
    McEwen BS (2000) Allostasis and allostatic load: implications for neuropsychopharmacology. Neuropsychopharmacology 22:108–124PubMedCrossRefGoogle Scholar
  73. 73.
    McEwen BS (2007) Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev 87:873–904PubMedCrossRefGoogle Scholar
  74. 74.
    McGowan PO, Sasaki A, D’Alessio AC, Dymov S, Labonte B, Szyf M, Turecki G, Meaney MJ (2009) Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 12:342–348PubMedPubMedCentralCrossRefGoogle Scholar
  75. 75.
    McWilliams LA, Asmundson GJ (2007) The relationship of adult attachment dimensions to pain-related fear, hypervigilance, and catastrophizing. Pain 127:27–34PubMedCrossRefGoogle Scholar
  76. 76.
    McWilliams LA, Cox BJ, Enns MW (2000) Impact of adult attachment styles on pain and disability associated with arthritis in a nationally representative sample. Clin J Pain 16:360–364PubMedCrossRefGoogle Scholar
  77. 77.
    Meaney MJ, Szyf M (2005) Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome. Dialogues Clin Neurosci 7:103–123PubMedPubMedCentralGoogle Scholar
  78. 78.
    Melzack R, Wall PD (1965) Pain mechanisms: a new theory. Science 150(699):971–979PubMedCrossRefGoogle Scholar
  79. 79.
    Meredith P, Ownsworth T, Strong J (2008) A review of the evidence linking adult attachment theory and chronic pain: presenting a conceptual model. Clin Psychol Rev 28:407–429PubMedCrossRefGoogle Scholar
  80. 80.
    Meredith P, Strong J, Feeney JA (2005) Evidence of a relationship between adult attachment variables and appraisals of chronic pain. Pain Res Manag 10:191–200PubMedCrossRefGoogle Scholar
  81. 81.
    Meredith P, Strong J, Feeney JA (2006) Adult attachment, anxiety, and pain self-efficacy as predictors of pain intensity and disability. Pain 12:146–154CrossRefGoogle Scholar
  82. 82.
    Mikulincer M, Florian V (1998) The relationship between adult attachment styles and emotional and cognitive reactions to stressful events. In: Simpson JA, Rholes WS (Hrsg) Attachment theory and close relationships. Guilford Press, New York, S 143–165Google Scholar
  83. 83.
    Moeller-Bertram T, Keltner J, Strigo IA (2012) Pain and post traumatic stress disorder – review of clinical and experimental evidence. Neuropharmacology 62:586–597PubMedCrossRefGoogle Scholar
  84. 84.
    Molnar DS, Flett GL, Sadava SW, Colautti J (2012) Perfectionism and health functioning in women with fibromyalgia. J Psychosom Res 73:295–300PubMedCrossRefGoogle Scholar
  85. 85.
    Nelson EC, Lynskey MT, Heath AC, Madden PAF, Martin NG (2010) A family study of adult twins with and without a history of childhood abuse: stability of retrospective reports of maltreatment and associated family measures. Twin Res Hum Genet 13:121–130PubMedPubMedCentralCrossRefGoogle Scholar
  86. 86.
    Neugebauer V (2007) The amygdala: different pains, different mechanisms. Pain 127:1–2PubMedCrossRefGoogle Scholar
  87. 87.
    Neugebauer V, Li W, Bird GC, Han JS (2004) The amygdala and persistent pain. Neuroscientist 10:221–234PubMedCrossRefGoogle Scholar
  88. 88.
    Nickel R, Egle UT (2001) Coping with conflict as a pathogenetic link between psychosocial adversities in childhood and psychic disorders in adulthood. Z Psychosom Med Psychother 47:332–347PubMedGoogle Scholar
  89. 89.
    Nilsen KB, Sand T, Westgaard RH, Stovner LJ, White LR, Bang LR, Helde G, Rø M (2007) Autonomic activation and pain in response to low-grade mental stress in fibromyalgia and shoulder/neck pain patients. Eur J Pain 11:743–755PubMedCrossRefGoogle Scholar
  90. 90.
    Olango WM, Finn DP (2014) Neurobiology of stress-induced hyperalgesia. Curr Top Behav Neurosci 20:251–280PubMedCrossRefGoogle Scholar
  91. 91.
    Overfeld J, Heim C (2015) Psychobiologische Folgen früher Stresserfahrungen. In: Egle UT, Joraschky P, Lampe A, Seiffge-Krenke I, Cierpka M (Hrsg) Sexueller Missbrauch, Misshandlung, Vernachlässigung. Erkennung, Therapie und Prävention der Folgen früher Stresserfahrungen. Schattauer, Stuttgart, S 41–65Google Scholar
  92. 92.
    Papaioannou M, Skapinakis P, Damigos D, Mavreas V, Broumas G, Palgimesi A (2009) The role of catastrophizing in the prediction of postoperative pain. Pain Med 10:1452–1459PubMedCrossRefGoogle Scholar
  93. 93.
    Pfau DB, Nickel RRR, Treede RD, Daublaender M (2009) Somatosensory profiles in subgroups of patients with myogenic temporomandibular disorders and fibromyalgia syndrome. Pain 147(1–3):72–83PubMedCrossRefGoogle Scholar
  94. 94.
    Raphael KG (2005) Childhood abuse and pain in adulthood: more than a modest relationship? Clin J Pain 21:371–373PubMedCrossRefGoogle Scholar
  95. 95.
    Rash J, Aguirre-Camacho A, Campbell TS (2014) Oxytocin and pain. A systematic review and synthesis of findings. Clin J Pain 30:453–462PubMedGoogle Scholar
  96. 96.
    Rhudy JL, Meagher MW (2000) Fear and anxiety: divergent effects on human pain thresholds. Pain 84:65–75PubMedCrossRefGoogle Scholar
  97. 97.
    Rhudy JL, Williams AE, McCabe KM, Rambo PL, Russell JL (2006) Emotional modulation of spinal nociception and pain: the impact of predictable noxious stimulation. Pain 126:221–233PubMedCrossRefGoogle Scholar
  98. 98.
    Rivat C, Laboureyras E, Laulin JP, Le Roy C, Richebé P, Simonnet G (2007) Non-nociceptive environmental stress induces hyperalgesia, not analgesia, in pain and opioid-experienced rats. Neuropsychopharmacology 32:2217–2228PubMedCrossRefGoogle Scholar
  99. 99.
    Roozendaal B, McEwen BS, Chatarij S (2009) Stress, memory and the amygdala. Nat Rev Neurosci 10:423–433PubMedCrossRefGoogle Scholar
  100. 100.
    Sapolsky RM (1996) Stress, glucocorticoids, and damage to the nervous system: The current state of confusion. Stress 1:1–19PubMedCrossRefGoogle Scholar
  101. 101.
    Sayar K, Gulec H, Topbas M (2004) Alexithymia and anger in patients with fibromyalgia. Clin Rheumatol 23:441–448PubMedCrossRefGoogle Scholar
  102. 102.
    Schmidt S, Nachtigall C, Wuethrich-Martone O, Strauss B (2002) Attachment and coping with chronic disease. J Psychosom Res 53:763–773PubMedCrossRefGoogle Scholar
  103. 103.
    Schulte IE, Petermann F (2011) Familial risk factors for the development of somatoform symptoms and disorders in children and adolescents: a systematic review. Child Psychiatry Hum Dev 42:569–583PubMedCrossRefGoogle Scholar
  104. 104.
    Schwaller F, Fitzgerald M (2014) The consequences of pain in early life: injury-induced plasticity in developing pain pathways. Eur J Neurosci 39:344–352PubMedPubMedCentralCrossRefGoogle Scholar
  105. 105.
    Scioli-Salter ER, Forman DE, Otis JD, Gregor K, Valovski I, Rasmusson AM (2015) The shared neuroanatomy and neurobiology of comorbid chronic pain and PTSD: therapeutic implications. Clin J Pain 31:363–374PubMedCrossRefGoogle Scholar
  106. 106.
    Spertus IL, Yehuda R, Wong CM, Halligan S, Seremetis SV (2003) Childhood emotional abuse and neglect as predictors of psychological and physical symptoms in women presenting to a primary care practise. Child Abuse Negl 27:1247–1258PubMedCrossRefGoogle Scholar
  107. 107.
    Stoeter P, Bauermann T, Nickel R, Corluka L, Gawehn J, Vucurevic G, Vossel G, Egle UT (2007) Cerebral activation in patients with somatoform pain disorder exposed to pain and stress: an fMRI study. Neuroimage 36:418–430PubMedCrossRefGoogle Scholar
  108. 108.
    Taddio A, Katz J, Ilersich AL, Koren G (1997) Effect of neonatal circumcision on pain response during subsequent routine vaccination. Lancet 349:599–603PubMedCrossRefGoogle Scholar
  109. 109.
    Teicher MH, Samson JA (2013) Childhood maltreatment and psychopathology: A case for ecophenotypic variants as clinically and neurobiologically distinct subtypes. Am J Psychiatry 170:1114–1133PubMedPubMedCentralCrossRefGoogle Scholar
  110. 110.
    Thompson T, Keogh E, French CC, Davis R (2008) Anxiety sensitivity and pain: generalisability across noxious stimuli. Pain 134:187–196PubMedCrossRefGoogle Scholar
  111. 111.
    Thyen U, Pott E (2015) Konzepte der Frühen Hilfen in Deutschland und das Nationale Zentrum Frühe Hilfen. In: Egle UT, Joraschky P, Lampe A, Seiffge-Krenke I, Cierpka M (Hrsg) Sexueller Missbrauch, Misshandlung, Vernachlässigung. Erkennung, Therapie und Prävention der Folgen früher Stresserfahrungen. Schattauer, Stuttgart, S 744–763Google Scholar
  112. 112.
    Ulirsch JC, Ballina LE, Soward AC, Rossi C, Hauda W, Holbrook D, Wheeler R, Foley KA, Batts J, Collette R, Goodman E, McLean SA (2014) Pain and somatic symptoms are sequelae of sexual assault: results of a prospective longitudinal study. Eur J Pain 18:559–566PubMedCrossRefGoogle Scholar
  113. 113.
    Uvnäs-Moberg K (1998) Antistress pattern induced by oxytocin. News Physiol Sci 13:22–25PubMedGoogle Scholar
  114. 114.
    van Houdenhove B, Egle UT (2004) Fibromyalgia – A stress disorder. Piecing the biopsychosocial puzzle together. Psychother Psychosom 73:267–275PubMedCrossRefGoogle Scholar
  115. 115.
    van Houdenhove B, Luyten P, Egle UT (2009) The role of childhood trauma in chronic pain and fatigue. In: Banyard VL, Edwards VJ, Kendall-Tackett KA (Hrsg) Trauma and physical health. Understanding the effects of extreme stress and of psychological harm. Routledge/Taylor & Francis, London, S 37–64Google Scholar
  116. 116.
    Van Oosterwijck J, Meeus M, Paul L, De Schryver M, Pascal A, Lambrecht L, Nijs J (2013) Pain physiology education improves health status and endogenous pain inhibition in fibromyalgia: a double-blind randomized controlled trial. Clin J Pain 29:873–882PubMedCrossRefGoogle Scholar
  117. 117.
    Vaughn F, Wichowski H, Bosworth G (2007) Does preoperative anxiety level predict postoperative pain? AORN J 85:589–604PubMedCrossRefGoogle Scholar
  118. 118.
    Vogt BA (2005) Pain and emotion. Interaction in subregions of the cingulate gyrus. Nat Rev Neurosci 6:533–544PubMedPubMedCentralCrossRefGoogle Scholar
  119. 119.
    Walker LS, Sherman AL, Bruehl S, Garber J, Smith CA (2012) Functional abdominal pain patient subtypes in childhood predict functional gastrointestinal disorders with chronic pain and psychiatric comorbidities in adolescence and adulthood. Pain 153:1798–1806PubMedPubMedCentralCrossRefGoogle Scholar
  120. 120.
    Waller E, Scheidt CE (2006) Somatoform disorders as disorders of affect regulation: a development perspective. Int Rev Psychiatry 18:13–24PubMedCrossRefGoogle Scholar
  121. 121.
    Weaver IC, Cervoni N, Champagne F, Meaney MJ (2004) Epigenetic programming by maternal behavior. Nat Neurosci 7:847–854PubMedCrossRefGoogle Scholar
  122. 122.
    Wegman HL, Stetler C (2009) A meta-analytic review of the effects of childhood abuse on medical outcomes in adulthood. Psychosom Med 71:805–812PubMedCrossRefGoogle Scholar
  123. 123.
    Wiech K, Ploner M, Tracey I (2008) Neurocognitive aspects of pain perception. Trends Cogn Sci 12:306–313PubMedCrossRefGoogle Scholar
  124. 124.
    Wiech K, Tracey I (2009) The influence of negative emotions on pain: behavioral effects and neural mechanisms. Neuroimage 47:987–994PubMedCrossRefGoogle Scholar
  125. 125.
    Williams AC, Eccleston C, Morley S (2012) Psychological therapies for the management of chronic pain (excluding headache) in adults. Cochrane Database Syst Rev 11:CD007407PubMedGoogle Scholar
  126. 126.
    Woolf J (2011) Central sensitization: Implications for the diagnosis and treatment of pain. Pain 152(3 Suppl):S2–S15PubMedCrossRefGoogle Scholar
  127. 127.
    Yancura LA, Aldwin CM (2009) Stability and change in retrospective reports of childhood experiences over a 5‑year period: Findings from the Davis Longitudinal Study. Psychol Aging 24:715–721PubMedCrossRefGoogle Scholar
  128. 128.
    Yoshida W, Seymour B, Koltzenburg M, Dolan RJ (2013) Uncertainty increases pain: evidence for a novel mechanism of pain modulation involving the periaqueductal gray. J Neurosci 33(13):5638–5646PubMedPubMedCentralCrossRefGoogle Scholar

Copyright information

© Deutsche Schmerzgesellschaft e.V. Published by Springer-Verlag Berlin Heidelberg - all rights reserved 2016

Authors and Affiliations

  1. 1.Dep. Psychosomatische Medizin, Klinik BarmelweidBarmelweid/AarauSchweiz
  2. 2.Kompetenzbereich für Psychosomatische Medizin, Univ.-Klinik für Allgemeine Innere MedizinInselspital BernBernSchweiz
  3. 3.Univ.-Klinik für NeurologieInselspital BernBernSchweiz

Personalised recommendations