Fibromyalgiesyndrom bei Kindern und Jugendlichen
- 214 Downloads
- 8 Citations
Zusammenfassung
Fragestellung
Erstellung einer interdisziplinären Leitlinie auf S3-Niveau zur Diagnostik und Therapie des juvenilen Fibromyalgiesyndroms (JFMS) in Kooperation von 10 medizinischen bzw. psychologischen Fachgesellschaften und 2 Patientenselbsthilfeorganisationen.
Methodik
Eine Literatursuche nach allen kontrollierten Studien zur Therapie des FMS wurde unter Benutzung der Cochrane Collaboration Reviews (1993–12/2006), Medline (1980-12/2006), PsychInfo (1966–12/2006) und Scopus (1980–12/2006) durchgeführt. Die Vergabe von Evidenzklassen erfolgte mittels des Systems des Oxford Centre for Evidence-Based Medicine. Empfehlungsgrade wurden nach der Empfehlungsgraduierung der nationalen Versorgungsleitlinien vergeben und in einem mehrstufigen nominalen Gruppenprozess erstellt.
Ergebnisse
Schmerzen bei Kindern/Jugendlichen in mehreren Körperregionen mit einer Dauer >3 Monaten ohne erkennbare somatische Ursache werden als juveniles FMS (JFMS) oder als „Schmerzverstärkungssyndrom“ (SVS) bezeichnet. Ein multimodales Konzept mit psycho- und physiotherapeutischen Verfahren, Entspannungstherapien und Schulungsprogrammen wird empfohlen (Empfehlungsgrad offen).
Schlussfolgerung
Diese Leitlinien werden zu einer besseren Erkennung und standardisierten Versorgung von JFMS-Patienten beitragen und die Durchführung klinischer Studien erleichtern.
Schlüsselwörter
Juveniles Fibromyalgiesyndrom Generalisiertes Schmerzverstärkungssyndrom Leitlinie Systematischer ReviewJuvenile fibromyalgia syndrome
Abstract
Objective
The aim was to develop a guideline for diagnostic procedures and treatment of juvenile fibromyalgia syndrome (JFMS) in cooperation with 10 German medical and psychological associations and 2 patient self-help groups.
Methods
A systematic literature search, including all controlled studies evaluating diagnosis and treatment of JFMS, was performed in the Cochran Collaboration Reviews (1993–12/2006), Medline (1980-12/2006), PsychInfo (1966–12/2006) and Scopus (1980–12/2006). Levels of evidence were assigned according to the classification system of the Oxford Centre for Evidence-Based Medicine. Grading of the strengths of recommendations was performed according to the German program for disease management guidelines. Standardized procedures to reach a consensus on recommendations were used.
Results
Pain in children/adolescents involving several body areas and lasting >3 months without an obvious somatic cause is called JFMS or pain amplification syndrome. Therapeutically, a multidisciplinary concept with psychotherapy and physiotherapy, relaxation techniques and patient education is recommended.
Conclusion
These guideline will contribute to a better recognition and standardized care of patients with JFMS and facilitate clinical studies.
Keywords
Juvenile fibromyalgia syndrome Diffuse amplified musculoskeletal pain syndrome Guideline Systematic reviewNotes
Interessenkonflikt
Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.
Literatur
- 1.Anthony KK, Schanberg LE (2001) Juvenile primary fibromyalgia syndrome. Curr Rheumatol Rep 3: 165–171PubMedCrossRefGoogle Scholar
- 2.Anthony KK, Schanberg LE (2003) Pain in children with arthritis: a review of the current literature. Arthritis Rheum 49: 272–279PubMedCrossRefGoogle Scholar
- 3.Arnold LM, Hudson JI, Hess EV et al. (2004) Family study of fibromyalgia. Arthritis Rheum 50: 944–952PubMedCrossRefGoogle Scholar
- 4.Buskila D, Neumann L (1996) Assessing functional disability and health status of women with fibromyalgia: validation of a Hebrew version of the Fibromyalgia Impact Questionnaire. J Rheumatol 23: 903–906PubMedGoogle Scholar
- 5.Buskila D, Neumann L (1997) Fibromyalgia syndrome (FM) and nonarticular tenderness in relatives of patients with FM. J Rheumatol 24: 941–944PubMedGoogle Scholar
- 6.Buskila D, Neumann L, Hershman E et al. (1995) Fibromyalgia syndrome in children – an outcome study. J Rheumatol 22: 525–528PubMedGoogle Scholar
- 7.Buskila D, Press J, Gedalia A et al. (1993) Assessment of nonarticular tenderness and prevalence of fibromyalgia in children. J Rheumatol 20: 368–370PubMedGoogle Scholar
- 8.Cabral DA, Tucker LB (1999) Malignancies in children who initially present with rheumatic complaints. J Pediatr 134: 53–57PubMedCrossRefGoogle Scholar
- 9.Clark P, Burgos-Vargas R, Medina-Palma C et al. (1998) Prevalence of fibromyalgia in children: a clinical study of Mexican children. J Rheumatol 25: 2009–2014PubMedGoogle Scholar
- 10.Conte PM, Walco GA, Kimura Y (2003) Temperament and stress response in children with juvenile primary fibromyalgia syndrome. Arthritis Rheum 48: 2923–2930PubMedCrossRefGoogle Scholar
- 11.Degotardi PJ, Klass ES, Rosenberg BS et al. (2006) Development and evaluation of a cognitive-behavioral intervention for juvenile fibromyalgia. J Pediatr Psychol 31: 714–723PubMedCrossRefGoogle Scholar
- 12.El Metwally A, Salminen JJ, Auvinen A et al. (2004) Prognosis of non-specific musculoskeletal pain in preadolescents: a prospective 4-year follow-up study till adolescence. Pain 110: 550–559CrossRefGoogle Scholar
- 13.Gedalia A, Garcia CO, Molina JF et al. (2000) Fibromyalgia syndrome: experience in a pediatric rheumatology clinic. Clin Exp Rheumatol 18: 415–419PubMedGoogle Scholar
- 14.Gedalia A, Press J, Klein M, Buskila D (1993) Joint hypermobility and fibromyalgia in schoolchildren. Ann Rheum Dis 52: 494–496PubMedCrossRefGoogle Scholar
- 15.Häfner R (2004) Juvenile Fibromyalgie – „Alles tut weh“. Akt Rheumatol 29: 142–143CrossRefGoogle Scholar
- 16.Häfner R, Beisken C (2004) Klinische Symptomatik bei entzündlich-rheumatischem Schmerz – physiotherapeutische Intervention. Akt Rheumatol 29: 133–136CrossRefGoogle Scholar
- 17.Häfner R, Michels H, Richter M et al. (2004) Fibromyalgie im Kindes- u. Jugendalter. Pädiatr Praxis 65: 681–689Google Scholar
- 18.Häuser W, Musial F, Kopp I, Bernardy K (2008) Methodische Grundlagen für die Entwicklung der Leitlinienempfehlungen (Methodenreport). Schmerz 22 (im Druck)Google Scholar
- 19.Jones GT, Silman AJ, Macfarlane GJ (2003) Predicting the onset of widespread body pain among children. Arthritis Rheum 48: 2615–2621PubMedCrossRefGoogle Scholar
- 20.Kashikar-Zuck S, Lynch AM, Graham TB et al. (2007) Social functioning and peer relationships of adolescents with juvenile fibromyalgia syndrome. Arthritis Rheum 57: 474–480PubMedCrossRefGoogle Scholar
- 21.Kashikar-Zuck S, Swain NF, Jones BA, Graham TB (2005) Efficacy of cognitive-behavioral intervention for juvenile primary fibromyalgia syndrome. J Rheumatol 32: 1594–1602PubMedGoogle Scholar
- 22.Keenan GF, Ostrov BE, Goldsmith DP, Athreya BH (1993) Rheumatic symptoms associated with hypothyroidism in children. J Pediatr 123: 586–588PubMedCrossRefGoogle Scholar
- 23.Kinsella JP, Irwin CE jr (1986) Erythromelalgia in an adolescent male. J Adolesc Health Care 7: 415–416PubMedCrossRefGoogle Scholar
- 24.Malleson PN, Al-Matar M, Petty RE (1992) Idiopathic musculoskeletal pain syndromes in children. J Rheumatol 19: 1786–1789PubMedGoogle Scholar
- 25.Merlijn VP, Hunfeld JA, van der Wouden JC et al. (2003) Psychosocial factors associated with chronic pain in adolescents. Pain 101: 33–43PubMedCrossRefGoogle Scholar
- 26.Michels H, Ganser G, Dannecker G et al. (2006) Strukturqualität von kinder- und jugendrheumatologischen Akutkliniken und -abteilungen – Projektgruppenarbeit der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR) und des Verbandes Rheumatologischer Akutkliniken (VRA). Z Rheumatol 65: 315–322PubMedCrossRefGoogle Scholar
- 27.Michels H, Mengel E, Huppertz H, Schaefer R (2006) Morbus Gaucher, Mukopolysaccharidose Typ I (Scheie) und Morbus Fabry. Spezifisch therapierbare lysosomale Speicherkrankheiten und wichtige Differenzialdiagnosen zu entzündlich-rheumatischen Erkrankungen. Monatsschr Kinderheilk 154: 347–359CrossRefGoogle Scholar
- 28.Mikkelsson M (1999) One year outcome of preadolescents with fibromyalgia. J Rheumatol 26: 674–682PubMedGoogle Scholar
- 29.Mikkelsson M, Kaprio J, Salminen JJ et al. (2001) Widespread pain among 11-year-old Finnish twin pairs. Arthritis Rheum 44: 481–485PubMedCrossRefGoogle Scholar
- 30.Mikkelsson M, Salminen JJ, Kautiainen H (1997) Non-specific musculoskeletal pain in preadolescents. Prevalence and 1-year persistence. Pain 73: 29–35PubMedCrossRefGoogle Scholar
- 31.Mikkelsson M, Salminen JJ, Sourander A, Kautiainen H (1998) Contributing factors to the persistence of musculoskeletal pain in preadolescents: a prospective 1-year follow-up study. Pain 77: 67–72PubMedCrossRefGoogle Scholar
- 32.Mikkelsson M, Sourander A, Piha J, Salminen JJ (1997) Psychiatric symptoms in preadolescents with musculoskeletal pain and fibromyalgia. Pediatrics 100: 220–227PubMedCrossRefGoogle Scholar
- 33.Neumann L, Buskila D (1997) Quality of life and physical functioning of relatives of fibromyalgia patients. Semin Arthritis Rheum 26: 834–839PubMedCrossRefGoogle Scholar
- 34.Palermo TM, Chambers CT (2005) Parent and family factors in pediatric chronic pain and disability: an integrative approach. Pain 119: 1–4PubMedCrossRefGoogle Scholar
- 35.Reid GJ, Lang BA, McGrath PJ (1997) Primary juvenile fibromyalgia: psychological adjustment, family functioning, coping, and functional disability. Arthritis Rheum 40: 752–760PubMedCrossRefGoogle Scholar
- 36.Reid GJ, McGrath PJ, Lang BA (2005) Parent-child interactions among children with juvenile fibromyalgia, arthritis, and healthy controls. Pain 113: 201–210PubMedCrossRefGoogle Scholar
- 37.Richter M, Häfner R, Schurer A et al. (2004) Das Garmischer Modell für die Behandlung von Schmerzpatienten in der Kinder- und Jugendrheumatologie. Akt Rheumatol 29: 158–163CrossRefGoogle Scholar
- 38.Richter M, Offenbächer M, Spamer M et al. (2006) Juvenile pain amplification syndromes- is multidisciplinary therapy the answer? Pain Res Manage 11 [suppl B]: C24Google Scholar
- 39.Roizenblatt S, Tufik S, Goldenberg J et al. (1997) Juvenile fibromyalgia: clinical and polysomnographic aspects. J Rheumatol 24: 579–585PubMedGoogle Scholar
- 40.Romano TJ (1991) Fibromyalgia in children; diagnosis and treatment. W V Med J 87: 112–114PubMedGoogle Scholar
- 41.Rosenberg AM (1990) Analysis of a pediatric rheumatology clinic population. J Rheumatol 17: 827–830PubMedGoogle Scholar
- 42.Roth-Isigkeit A, Thyen U, Stoven H et al. (2005) Pain among children and adolescents: restrictions in daily living and triggering factors. Pediatrics 115: e152–e162PubMedCrossRefGoogle Scholar
- 43.Saccomani L, Vigliarolo MA, Sbolgi P et al. (1993) Juvenile fibromyalgia syndrome: 2 clinical cases. Pediatr Med Chir 15: 99–101PubMedGoogle Scholar
- 44.Schanberg LE, Anthony KK, Gil KM et al. (2001) Family pain history predicts child health status in children with chronic rheumatic disease. Pediatrics108: E47Google Scholar
- 45.Schanberg LE, Keefe FJ, Lefebvre JC et al. (1998) Social context of pain in children with juvenile primary fibromyalgia syndrome: parental pain history and family environment. Clin J Pain 14: 107–115PubMedCrossRefGoogle Scholar
- 46.Sherry DD (2001) Diagnosis and treatment of amplified musculoskeletal pain in children. Clin Exp Rheumatol 19: 617–620PubMedGoogle Scholar
- 47.Sherry DD (2004) Diagnose und Therapie von Schmerzverstärkungssyndromen bei Kindern: Erfahrung aus zwei Jahrzehnten. Akt Rheumatol 29: 137–141CrossRefGoogle Scholar
- 48.Sherry DD, Malleson PN (2002) The idiopathic musculoskeletal pain syndromes in childhood. Rheum Dis Clin North Am 28: 669–685PubMedCrossRefGoogle Scholar
- 49.Sherry DD, McGuire T, Mellins E et al. (1991) Psychosomatic musculoskeletal pain in childhood: clinical and psychological analyses of 100 children. Pediatrics 88: 1093–1099PubMedGoogle Scholar
- 50.Sherry DD, Wallace CA, Kelley C et al. (1999) Short- and long-term outcomes of children with complex regional pain syndrome type I treated with exercise therapy. Clin J Pain 15: 218–223PubMedCrossRefGoogle Scholar
- 51.Siegel DM, Janeway D, Baum J (1998) Fibromyalgia syndrome in children and adolescents: clinical features at presentation and status at follow-up. Pediatrics 101: 377–382PubMedCrossRefGoogle Scholar
- 52.Stormorken H, Brosstad F (1992) Fibromyalgia: family clustering and sensory urgency with early onset indicate genetic predisposition and thus a „true“ disease. Scand J Rheumatol 21: 207PubMedCrossRefGoogle Scholar
- 53.Trapani S, Grisolia F, Simonini G et al. (2000) Incidence of occult cancer in children presenting with musculoskeletal symptoms: a 10-year survey in a pediatric rheumatology unit. Semin Arthritis Rheum 29: 348–359PubMedCrossRefGoogle Scholar
- 54.Vandvik IH, Forseth KO (1994) A bio-psychosocial evaluation of ten adolescents with fibromyalgia. Acta Paediatr 83: 766–771PubMedCrossRefGoogle Scholar
- 55.Varni JW, Burwinkle TM, Limbers CA, Szer IS (2007) The PedsQL as a patient-reported outcome in children and adolescents with fibromyalgia: an analysis of OMERACT domains. Health Qual Life Outcomes 5: 9PubMedCrossRefGoogle Scholar
- 56.Varni JW, Burwinkle TM, Szer IS (2004) The PedsQL multidimensional fatigues scale in pediatric rheumatology: reliability and validity. J Rheumatol 31: 2494–2500PubMedGoogle Scholar
- 57.Varni JW, Seid M, Rode CA (1999) The PedsQL: measurement model for the pediatric quality of life inventory. Med Care 37: 126–139PubMedCrossRefGoogle Scholar
- 58.Walco GA, Varni JW, Ilowite NT (1992) Cognitive-behavioral pain management in children with juvenile rheumatoid arthritis. Pediatrics 89: 1075–1079PubMedGoogle Scholar
- 59.Walker LS, Williams SE, Smith CA et al. (2006) Parent attention versus distraction: impact on symptom complaints by children with and without chronic functional abdominal pain. Pain 122: 43–52PubMedCrossRefGoogle Scholar
- 60.Yunus MB, Khan MA, Rawlings KK et al. (1999) Genetic linkage analysis of multicase families with fibromyalgia syndrome. J Rheumatol 26: 408–412PubMedGoogle Scholar
- 61.Yunus MB, Masi AT (1985) Juvenile primary fibromyalgia syndrome. A clinical study of thirty-three patients and matched normal controls. Arthritis Rheum 28: 138–145PubMedCrossRefGoogle Scholar
- 62.Zernikow B, Damschen U (2005) Schmerzdokumentation in der Praxis. Klassifikation, Stadieneinteilung, Schmerzfragebögen. Springer, Berlin Heidelberg New YorkGoogle Scholar