Pediatric Nephrology

, Volume 14, Issue 6, pp 513–517 | Cite as

Transplantation of renal precursor cells: a new therapeutic approach

  • M. R. Hammerman
Developmental Biology Review


The number of kidney transplantations performed per year is limited due to availability of donor organs. One possible solution to the organ shortage is the use of renal xenografts. However, the transplantation of xenografts is complicated by hyperacute and acute rejection. It has been postulated that the host immune response might be attenuated following the transplantation of renal precursor cells or embryonic kidneys (metanephroi) instead of developed (adult) kidneys. Transplanted metanephroi become chimeric organs in that their blood supply originates, at least in part, from the host. It is possible to transplant a developing metanephros, without the use of immunosuppression, from one rat to another. Transplanted metanephroi grow, develop, become vascularized, and function in host rats. Transplantation of metanephroi may be a promising novel therapeutic approach for the treatment of chronic renal failure.

Key words Allograft Metanephros Transplantation Xenograft 


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Copyright information

© IPNA - International Pediatric Nephrology Association New York, USA 2000

Authors and Affiliations

  • M. R. Hammerman
    • 1
  1. 1.George M. O’Brien Kidney and Urological Disease Center, Renal Division, Departments of Medicine, Cell Biology, and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USAUS

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