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Pediatric Nephrology

, Volume 11, Issue 4, pp 477–480 | Cite as

Complement activation in Henoch-Schönlein purpura

  • Graham C. Smith
  • Joyce E. Davidson
  • David A. Hughes
  • Elizabeth Holme
  • T. James Beattie
Original article

Abstract.

The pathogenetic mechanism underlying Henoch-Schönlein purpura (HSP) is poorly understood. Complement activation has been thought to have a role, but despite the demonstration of complement components in skin and renal biopsy material, serological evidence of complement activation is not convincing. We have assessed complement activation in 64 children with acute HSP. We used an enzyme-linked immunosorbent assay to measure plasma levels of three multimolecular complement activation protein (CAP) complexes: C1r: C1s: C1-inhibitor, C3bP and C5b-9. We found no significant difference between the levels of CAPs in children with acute HSP and a control group of children. This study does not support a role for complement activation in the pathogenesis of HSP.

Key words: Henoch-Schönlein purpura Complement activation 

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Copyright information

© IPNA - International Pediatric Nephrology Association New York, USA 1997

Authors and Affiliations

  • Graham C. Smith
    • 1
  • Joyce E. Davidson
    • 1
  • David A. Hughes
    • 1
  • Elizabeth Holme
    • 2
  • T. James Beattie
    • 1
  1. 1.Department of Nephrology, Royal Hospital for Sick Children, Glasgow, ScotlandGB
  2. 2.Department of Immunology, Western Infirmary, Glasgow, ScotlandGB

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