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Pediatric Nephrology

, Volume 11, Issue 1, pp 36–39 | Cite as

Possible person-to-person transmission of Escherichia coli O111 – associated hemolytic uremic syndrome

  • B. Boudailliez
  • P. Berquin
  • P. Mariani-Kurkdjian
  • D. D Ilef
  • B. Cuvelier
  • I. Capek
  • B. Tribout
  • E. Bingen
  • C. Piussan
Original article

Abstract

.Over a 3-month period, ten children (aged 1–13 years) from a 15-km radius in southern Picardy developed typical D+ hemolytic uremic syndrome (HUS). Polymerase chain reaction, using two pairs of verocytotoxin 1-(VT1) and VT2-specific oligonucleotide primers and an internal control was used to detect VT genes directly from stools samples. VT2 gene was detected in seven of nine patients’ stools and in 5 of 14 contacts’ stool samples. A VT2-producing Escherichia coli (VTEC) O111 was isolated from five of nine children’s stools and in 3 adults’ stools of the 14 tested. A retrospective case-control study was performed which showed a higher rate of absence in school A, where the first four cases were detected, compared with a control school. The odds ratio for the whole school was 2.77 (confidence interval 1.46 – 5.26), and 15 (confidence interval 2.54 – 115.6) if only the nursery classes were considered. A culture of all food samples from households was always negative for VTEC. A retrospective cohort study performed in 89% of children attending school A showed no linkage between food or drink and gastroenteritis. These findings emphasize the potential for person-to-person transmission of VT2-producing E. coli O111, since the only salient risk factor was close contact.

Key words: Hemolytic uremic syndrome Epidemiology Escherichia coli O111 Disease outbreaks 

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Copyright information

© IPNA - International Pediatric Nephrology Association New York, USA 1997

Authors and Affiliations

  • B. Boudailliez
    • 1
  • P. Berquin
    • 1
  • P. Mariani-Kurkdjian
    • 2
  • D. D Ilef
    • 3
  • B. Cuvelier
    • 4
  • I. Capek
    • 3
  • B. Tribout
    • 1
  • E. Bingen
    • 2
  • C. Piussan
    • 1
  1. 1.Department of Pediatrics, CHU Nord, F-80054 Amiens, FranceFR
  2. 2.Microbiology Laboratory, Hôpital Robert Debré, F-75019 Paris, FranceFR
  3. 3.DRASS, Epidemiology Department, F-80000 Amiens, FranceFR
  4. 4.Department of Pediatric, CH, F-60000 Beauvais, FranceFR

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