Pediatric Nephrology

, Volume 15, Issue 3–4, pp 192–195 | Cite as

Experimental intrauterine growth retardation alters renal development

  • H. Bassan
  • Leonor Leider Trejo
  • Naam Kariv
  • Merav Bassan
  • Esther Berger
  • Aviva Fattal
  • Illana Gozes
  • Shaul Harel
Experimental Studies / Original Article

Abstract 

Vascular placental insufficiency is considered a common pathogenic factor in human intrauterine growth retardation (IUGR), resulting in small-for-gestational-age, asymmetric newborns. IUGR neonates experience higher morbidity and mortality rates, as well as a possible contribution towards late sequelae, such as hypertension, and cardiovascular disease in adulthood. To simulate vascular placental insufficiency, an experimental rabbit IUGR model was used. Intrauterine growth retardation was achieved by ligation of 25–30% uteroplacental vessels of half of the fetuses during the last third of gestation. Ischemic fetuses were significantly small, asymmetric, and had a disproportionately small body with a relatively large head. The kidneys from all groups were analyzed for relative estimated glomeruli number (REGN) using an unbiased blind design. The glomeruli number was significantly reduced in the asymmetric IUGR rabbit fetuses, probably due to decreased renal vascular supply. Our results support the concept that the reduced number of glomeruli may contribute to impaired renal function, thus predisposing to neonatal renal dysfunction and late sequelae, such as adult hypertension. This study emphasizes the clinical importance of early IUGR diagnosis and prevention.

Key words Intrauterine growth retardation Rabbit model Glomerulus Hypertension 

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Copyright information

© IPNA - International Pediatric Nephrology Association New York, USA 2000

Authors and Affiliations

  • H. Bassan
    • 1
  • Leonor Leider Trejo
    • 3
  • Naam Kariv
    • 4
  • Merav Bassan
    • 2
  • Esther Berger
    • 3
  • Aviva Fattal
    • 1
  • Illana Gozes
    • 2
  • Shaul Harel
    • 1
  1. 1.The Institute for Child Development, Division of Pediatrics, Tel Aviv Sourasky Medical Center, Beit Habriut Strauss, 14 Balfour Street, Tel Aviv 65211, Israel e-mail: child@netvision.net.il Tel.: +972-3-5250598, Fax: +972-3-6203177IL
  2. 2.Department of Clinical Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelIL
  3. 3.Department of Pathology, Tel Aviv Sourasky Medical Center, Tel Aviv, IsraelIL
  4. 4.David Glasberg Tower for Medical Research, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelIL

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