A child with anemia, thrombocytopenia, renal failure and elevated amylase, and lipase enzymes: Answers
What is your diagnosis?
Thrombotic microangiopathy (TMA) should be considered in this patient with a decrease in urinary output, deterioration of renal function tests, thrombocytopenia, and findings consistent with hemolysis in peripheral blood spread.
Thrombotic microangiopathies describe a group of diseases with clinic of anemia, thrombocytopenia, and acute renal failure. These diseases classified as the name hemolytic uremic syndromes (HUS). The common pathological features in these diseases, endothelial cell injury, microthrombus formation, and multiorgan injury .
Causes of thrombotic microangiopathies
Shiga toxin-associated HUS (ST-HUS)
Thrombotic thrombocytopenic purpura (TTP)
A disintegrin and metalloprotease with thrombospondin type 1 repeats member 13
Hemolytic uremic syndrome
Tumor necrosis factor-α
Thrombotic thrombocytopenic purpura
Ultra large von Willebrand factor
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.