Pediatric Nephrology

, Volume 34, Issue 2, pp 349–352 | Cite as

Soluble tumor necrosis factor receptors are associated with severity of kidney dysfunction in pediatric chronic kidney disease

  • Janaina Matos Moreira
  • Albená Nunes da Silva
  • Érica Leandro Marciano Vieira
  • Antônio Lúcio Teixeira
  • Arthur Melo Kummer
  • Ana Cristina Simões e Silva
Brief Report
Part of the following topical collections:
  1. What’s New in Chronic Kidney Disease



In adult chronic kidney disease (CKD) patients, there is a positive association between inflammation and progressive renal dysfunction. Higher levels of soluble receptors of tumor necrosis factor (sTNFR) have been related to worst prognosis of adult CKD patients. Therefore, the present study aimed to evaluate soluble TNF receptors in children and adolescents with CKD and to search for an association with clinical and laboratory features.


Demographic, clinical, anthropometric, and laboratory data were evaluated in 34 pediatric patients with CKD and in 34 healthy sex- and age-matched controls. Blood samples were collected in both groups to measure sTNFR by enzyme-linked immunosorbent assay. The modified Schwartz formula was used to estimate glomerular filtration rate (GFR).


Pediatric patients with CKD had significantly higher plasma concentrations of soluble TNF receptors types 1 and 2 (sTNFR1 and sTNFR2) in comparison to sex- and age-matched healthy controls. Plasma levels of sTNFR1 and sTNFR2 increased progressively as renal function worsened, being inversely and significantly correlated with GFR (r = − 0.853 for sTNFR1 and GFR, r = − 0.729 for sTNFR2 and GFR).


Children and adolescents with CKD exhibited higher plasma levels of sTNFR1 and sTNFR2 than healthy controls, which increased in relation to renal function deterioration. Plasma levels of sTNFR1 and sTNFR2 emerge as markers of progressive CKD in pediatric patients.


Inflammation Tumor necrosis factor Chronic kidney disease Cytokines Glomerular filtration rate Children 


Funding information

This study was partially supported by PRPQ-UFMG (Programa Institucional de Auxílio à Pesquisa de Docentes Recém-Contratados), CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil), FAPEMIG (Fundação de Amparo à Pesquisa do Estado de Minas Gerais, Brazil), and CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior). Dr. A.L. Teixeira and Dr. A.C. Simões e Silva receive a research productivity grant from CNPq.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

467_2018_4124_MOESM1_ESM.docx (15 kb)
ESM 1 (DOCX 15 kb)


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Copyright information

© IPNA 2018

Authors and Affiliations

  • Janaina Matos Moreira
    • 1
    • 2
  • Albená Nunes da Silva
    • 3
  • Érica Leandro Marciano Vieira
    • 1
  • Antônio Lúcio Teixeira
    • 1
  • Arthur Melo Kummer
    • 1
  • Ana Cristina Simões e Silva
    • 1
    • 2
    • 4
  1. 1.Interdisciplinary Laboratory of Medical Research (LIIM) of the Federal University of Minas Gerais (UFMG)Belo HorizonteBrazil
  2. 2.Pediatric Nephrology Unit, Department of Pediatrics, Faculty of MedicineUFMGBelo HorizonteBrazil
  3. 3.Exercise Immunology and Inflammation Laboratory (LABIIEX/CEDUFOP)Federal University of Ouro PretoOuro PretoBrazil
  4. 4.Laboratório Interdisciplinar de Investigação Médica, Faculdade de MedicinaBelo HorizonteBrazil

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