Risk factors for early B cell recovery following single-dose rituximab therapy in Japanese children with steroid-dependent nephrotic syndrome
We read with great interest the article titled, “Effect of different rituximab regimens on B cell depletion and time to relapse in children with steroid-dependent nephrotic syndrome” by Dr. Hogan et al. . Based on the retrospective study of 61 French patients receiving various initial rituximab (RTX) regimens (single low dose of 100 mg/m2, single standard dose of 375 mg/m2, or two standard doses of 375 mg/m2), the authors showed that a lower initial dose of RTX and younger age at RTX initiation were significantly associated with a shorter time to B cell reconstitution, which may have an impact on the increased risk of nephrotic syndrome (NS) relapse. The authors also reported that the need for methylprednisolone pulses to achieve remission and a high level of steroid dependency requiring cyclosporine A (CsA) before RTX administration were significantly associated with a higher risk of NS relapse following RTX treatment. They concluded that the initial RTX dose could be...
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Conflict of interest
The authors declare that they have no conflicts of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
- 1.Hogan J, Dossier C, Kwon T, Macher MA, Maisin A, Couderc A, Niel O, Baudouin V, Deschênes G (2018) Effect of different rituximab regimens on B cell depletion and time to relapse in children with steroid-dependent nephrotic syndrome. Pediatr Nephrol. https://doi.org/10.1007/s00467-018-4052-x