Pediatric Nephrology

, Volume 32, Issue 4, pp 685–695

Racial–ethnic disparities in mortality and kidney transplant outcomes among pediatric dialysis patients

  • Marciana Laster
  • Melissa Soohoo
  • Clinton Hall
  • Elani Streja
  • Connie M. Rhee
  • Vanessa A. Ravel
  • Uttam Reddy
  • Keith C. Norris
  • Isidro B. Salusky
  • Kamyar Kalantar-Zadeh
Original Article

DOI: 10.1007/s00467-016-3530-2

Cite this article as:
Laster, M., Soohoo, M., Hall, C. et al. Pediatr Nephrol (2017) 32: 685. doi:10.1007/s00467-016-3530-2

Abstract

Background

Previous studies in adult hemodialysis patients have shown that African–American and Hispanic patients have a lower risk of mortality in addition to a lower likelihood of kidney transplantation. However, studies of the association between race and outcomes in pediatric dialysis are sparse and often do not examine outcomes in Hispanic children. The objective was to determine if racial–ethnic disparities in mortality and kidney transplantation outcomes exist in pediatric dialysis patients.

Methods

This was a retrospective cohort analysis of 2,697 pediatric dialysis patients (aged 0–20 years) from a large national dialysis organization (entry period 2001–2011) of non-Hispanic white, African–American, and Hispanic race-ethnicity. Associations between race–ethnicity with mortality and kidney transplantation outcomes were examined separately using competing risks methods. Logistic regression analyses were used to examine the association between race–ethnicity, with outcomes within 1 year of dialysis initiation.

Results

Of the 2,697 pediatric patients in this cohort, 895 were African–American, 778 were Hispanic, and 1,024 were non-Hispanic white. After adjusting for baseline demographics, competing risk survival analysis revealed that compared with non-Hispanic whites, African–Americans had a 64 % higher mortality risk (hazards ratio [HR] = 1.64; 95 % CI 1.24–2.17), whereas Hispanics had a 31 % lower mortality risk (HR = 0.69; 95 % CI 0.47–1.01) that did not reach statistical significance. African–Americans also had higher odds of 1-year mortality after starting dialysis (odds ratio [OR] = 2.08; 95 % CI 0.95–4.58), whereas both African–Americans and Hispanics had a lower odds of receiving a transplant within 1 year of starting dialysis (OR = 0.28; 95 % CI 0.19–0.41 and OR = 0.43; 95 % CI 0.31–0.59 respectively).

Conclusion

In contrast to adults, African–American pediatric dialysis patients have worse survival than their non-Hispanic white counterparts, whereas Hispanics have a similar to lower mortality risk. Both African–American and Hispanic pediatric dialysis patients had a lower likelihood of kidney transplantation than non-Hispanic whites, similar to observations in the adult dialysis population.

Keywords

Race Ethnicity African–American Hispanic Pediatric End-stage renal disease Dialysis Mortality Transplant 

Supplementary material

467_2016_3530_MOESM1_ESM.docx (23 kb)
Supplemental Table 1(DOCX 23 kb)

Funding information

Funder NameGrant NumberFunding Note
National Institute of Diabetes and Digestive and Kidney Diseases
  • R01-DK95668
  • K24-DK091419
  • R01-DK078106
  • K23-DK102903
  • T32-DK104687

Copyright information

© IPNA 2016

Authors and Affiliations

  • Marciana Laster
    • 1
  • Melissa Soohoo
    • 2
  • Clinton Hall
    • 3
  • Elani Streja
    • 2
  • Connie M. Rhee
    • 2
    • 4
  • Vanessa A. Ravel
    • 2
  • Uttam Reddy
    • 4
  • Keith C. Norris
    • 1
  • Isidro B. Salusky
    • 1
  • Kamyar Kalantar-Zadeh
    • 1
    • 2
    • 4
  1. 1.David Geffen School of Medicine at UCLALos AngelesUSA
  2. 2.Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, School of MedicineUniversity of California IrvineOrangeUSA
  3. 3.Department of EpidemiologyUCLA Fielding School of Public HealthLos AngelesUSA
  4. 4.Division of Nephrology and Hypertension, School of MedicineUniversity of California IrvineOrangeUSA

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