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Pediatric Nephrology

, Volume 31, Issue 12, pp 2299–2308 | Cite as

Epidemiology of idiopathic nephrotic syndrome in children: endemic or epidemic?

  • Claire DossierEmail author
  • Nathanael Lapidus
  • Florian Bayer
  • Anne-Laure Sellier-Leclerc
  • Olivia Boyer
  • Loic de Pontual
  • Adrien May
  • Sylvie Nathanson
  • Christine Orzechowski
  • Tabassome Simon
  • Fabrice Carrat
  • Georges Deschênes
Original Article

Abstract

Background

The etiology of idiopathic nephrotic syndrome (INS) remains partially unknown. Viral infections have been reported to be associated with INS onset and relapse. The aim of this study was to describe the epidemiology of a population-based cohort of children with INS and propose a spatiotemporal analysis.

Methods

All children aged 6 months to 15 years with INS onset between December 2007 and May 2010 and living in the Paris area were included in a prospective multicenter study. Demographic and clinical features at diagnosis and 2 years were collected.

Results

INS was diagnosed in 188 children, 93 % of whom were steroid sensitive. Annual incidence was 3.35/100,000 children. Standardized incidence ratio (SIR) was higher in one of the eight counties: Seine-Saint-Denis, with SIR 1.43 [95 % confidence interval (CI) 1.02–1.95]. A spatial cluster was further identified with higher SIR 1.36 (95 % CI 1.09–1.67). Temporal analysis within this overincidence area showed seasonal variation, with a peak during the winter period (p <0.01). In addition, partition of the Paris area into quintiles of the population showed that the average delay of occurrence, with regard to the first study case, followed a longitudinal progression (p <0.0001).

Conclusion

The clustering of cases, the seasonal variation within this particular area, and the progression over the Paris area altogether suggest that INS may occur on an epidemic mode.

Keywords

Nephrotic syndrome Childhood Epidemiology Cluster Seasonal periodicity 

Notes

Compliance with ethical standards

Conflict of interest

All authors declare no conflict of interest.

Ethical statement

The study was reviewed and accepted by the local ethic committee. A written informed consent was systematically signed by the parents and, when possible, by the patient (age >10 years).

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Copyright information

© IPNA 2016

Authors and Affiliations

  • Claire Dossier
    • 1
    Email author
  • Nathanael Lapidus
    • 2
    • 3
  • Florian Bayer
    • 4
  • Anne-Laure Sellier-Leclerc
    • 5
  • Olivia Boyer
    • 6
  • Loic de Pontual
    • 7
  • Adrien May
    • 8
  • Sylvie Nathanson
    • 9
  • Christine Orzechowski
    • 10
  • Tabassome Simon
    • 11
  • Fabrice Carrat
    • 2
    • 3
  • Georges Deschênes
    • 1
  1. 1.Service de Néphrologie PédiatriqueHôpital Robert-Debré, APHPParisFrance
  2. 2.Sorbonne Universités, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique (IPLESP UMRS 1136)ParisFrance
  3. 3.Department of Public HealthHôpital Saint-Antoine, AP-HPParisFrance
  4. 4.Agence de la BiomédecineSaint-Denis La PlaineParisFrance
  5. 5.Service de Néphrologie PédiatriqueHospices Civiles de LyonLyonFrance
  6. 6.Service de Néphrologie PédiatriqueNecker-Enfants-Malades, APHPParisFrance
  7. 7.Service de PédiatrieHôpital Jean-Verdier, APHPBondyFrance
  8. 8.Service de PédiatrieCentre Hospitalier Sud FrancilienCorbeil-EssonneFrance
  9. 9.Service de PédiatrieCentre Hospitalier de VersaillesLe ChesnayFrance
  10. 10.Service de PédiatrieHôpital Saint-Camille Bry-sur-MarneLe ChesnayFrance
  11. 11.Unité de Recherche Clinique URC-EstUniversité Paris 6ParisFrance

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