Pediatric Nephrology

, Volume 31, Issue 12, pp 2379–2380 | Cite as

Acute kidney injury due to rotavirus gastroenteritis-associated obstructive uric acid stones in a Japanese infant harboring a heterozygous W258X mutation

  • Shuichiro FujinagaEmail author
  • Tomohiko Nishino
Letter to the Editor


We read with interest the article entitled “Uric acid and the kidney” by Fathallah-Shaykh and Kramer, in which rotavirus-associated gastroenteritis (RV-GE) was described as a cause of uric acid stone formation [1]. Here, we would like to comment on a genetic factor that predisposes Japanese children to RV-GE-associated uric acid stones. In 2005, we first reported a case of a 13-month-old boy with acute kidney injury (AKI) caused by obstructive uric acid stones of the bilateral pelviureteric junctions after RV-GE [2]. At that time, we postulated that the formation of RV-GE-associated uric acid stones was mainly due to hyperuricemia resulting from massive tissue breakdown in the infected gastrointestinal tract in combination with severe dehydration. Since then, many reports of uric acid stone development after RV-GE in only Japanese children have been reported. More recently, several case reports of similar post-renal AKI in infants with GE caused by other viruses, such as...


Uric Acid Acute Kidney Injury Serum Uric Acid Level Japanese Child Uric Acid Stone 
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The authors wish to thank Dr Matsuo (National Defense Medical Collage, Saitama, Japan) for performing sequence analysis of the SLC22A12 gene in the patient and his family members.

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflicts of interest.


  1. 1.
    Fathallah-Shaykh SA, Cramer MT (2014) Uric acid and the kidney. Pediatr Nephrol 29:999–1008CrossRefPubMedGoogle Scholar
  2. 2.
    Fujinaga S, Kaneko K, Ohtomo Y, Takada M, Kobayashi K, Tada M, Yamashiro Y (2005) Acute renal failure due to obstructive uric acid stones associated with rotavirus gastroenteritis. Pediatr Nephrol 20:239–240CrossRefPubMedGoogle Scholar
  3. 3.
    Iwai N, Mino Y, Hosoyamada M, Tago N, Kokubo Y, Endou H (2004) A high prevalence of renal hypouricemia caused by inactive SLC22A12 in Japanese. Kidney Int 66:935–944CrossRefPubMedGoogle Scholar

Copyright information

© IPNA 2016

Authors and Affiliations

  1. 1.Division of NephrologySaitama Children’s Medical CenterSaitama-cityJapan

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