Pediatric Nephrology

, Volume 31, Issue 5, pp 693–706 | Cite as

Tubular atrophy in the pathogenesis of chronic kidney disease progression

Review
First Online:
Received:
Revised:
Accepted:

Abstract

The longstanding focus in chronic kidney disease (CKD) research has been on the glomerulus, which is sensible because this is where glomerular filtration occurs, and a large proportion of progressive CKD is associated with significant glomerular pathology. However, it has been known for decades that tubular atrophy is also a hallmark of CKD and that it is superior to glomerular pathology as a predictor of glomerular filtration rate decline in CKD. Nevertheless, there are vastly fewer studies that investigate the causes of tubular atrophy, and fewer still that identify potential therapeutic targets. The purpose of this review is to discuss plausible mechanisms of tubular atrophy, including tubular epithelial cell apoptosis, cell senescence, peritubular capillary rarefaction and downstream tubule ischemia, oxidative stress, atubular glomeruli, epithelial-to-mesenchymal transition, interstitial inflammation, lipotoxicity and Na+/H+ exchanger-1 inactivation. Once a a better understanding of tubular atrophy (and interstitial fibrosis) pathophysiology has been obtained, it might then be possible to consider tandem glomerular and tubular therapeutic strategies, in a manner similar to cancer chemotherapy regimens, which employ multiple drugs to simultaneously target different mechanistic pathways.

Keywords

Apoptosis Chronic kidney disease Interstitial fibrosis Lipotoxicity NHE1 
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Notes

Acknowledgments

I am grateful to Drs. Katherine Dell and John O’Toole for careful review of the manuscript. Dr. Schelling is supported by NIH grants NIH 2R01 DK067528 and 2U01 DK061021.

Conflict of interest

The author declares that he has no conflict of interest.

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© IPNA 2015

Authors and Affiliations

  1. 1.Department of MedicineCase Western Reserve UniversityClevelandUSA
  2. 2.Rammelkamp Center for Education and ResearchMetroHealth Medical CenterClevelandUSA

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