Renal function in adult women with urinary tract infection in childhood
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The risk of deterioration of renal function in patients with urinary tract infection (UTI)-associated renal damage over several decades is incompletely known but of importance in regard to follow-up.
A population-based cohort of women followed from their first UTI in childhood was studied at median age of 27 years and now at 41 years. Renal damage was evaluated by 99mTc-dimercaptosuccinic acid scan and glomerular filtration rate (GFR) by 51Cr-edetic acid clearance. Extent of individual kidney damage was graded as class 1 to 3.
Eighty-six women completed the investigation, 58 with renal damage, and 28 without. Of those with damage, one had chronic kidney disease (CKD) stage 3, 14 stage 2, and 43 stage 1. Women with bilateral damage had lower GFR than those with no or unilateral damage (p < 0.0001). Women with class 3 damage had numerically but not significantly lower GFR than the others with damage (p = 0.07). Between the two studies there was significant decrease of GFR in the group with bilateral damage (p = 0.01).
Women with UTI-associated renal damage had remarkably well preserved renal function, but those with bilateral or severe individual kidney damage may be considered for regular monitoring of GFR and blood pressure.
KeywordsChronic kidney disease DMSA scan Glomerular filtration rate Hypertension Renal damage
Ambulatory blood pressure monitoring
Chronic kidney disease
Glomerular filtration rate
Standard deviation score
Urinary tract infection
We thank Marie Magnusson for help with GFR measurements and Aldina Pivodic for assistance with statistical calculations. Financial support was provided by grants from the West Region, Sweden and the Gothenburg Medical Society.
Financial support was provided by grants from the West Region, Sweden and the Gothenburg Medical Society.
Conflict of interest
The authors declare that they have no conflicts of interest.
Informed consent was obtained from all individual participants included in the study.
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