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Pediatric Nephrology

, Volume 30, Issue 9, pp 1493–1499 | Cite as

Renal function in adult women with urinary tract infection in childhood

  • Carin GebäckEmail author
  • Sverker Hansson
  • Jeanette Martinell
  • Torsten Sandberg
  • Rune Sixt
  • Ulf Jodal
Original Article

Abstract

Background

The risk of deterioration of renal function in patients with urinary tract infection (UTI)-associated renal damage over several decades is incompletely known but of importance in regard to follow-up.

Methods

A population-based cohort of women followed from their first UTI in childhood was studied at median age of 27 years and now at 41 years. Renal damage was evaluated by 99mTc-dimercaptosuccinic acid scan and glomerular filtration rate (GFR) by 51Cr-edetic acid clearance. Extent of individual kidney damage was graded as class 1 to 3.

Results

Eighty-six women completed the investigation, 58 with renal damage, and 28 without. Of those with damage, one had chronic kidney disease (CKD) stage 3, 14 stage 2, and 43 stage 1. Women with bilateral damage had lower GFR than those with no or unilateral damage (p < 0.0001). Women with class 3 damage had numerically but not significantly lower GFR than the others with damage (p = 0.07). Between the two studies there was significant decrease of GFR in the group with bilateral damage (p = 0.01).

Conclusions

Women with UTI-associated renal damage had remarkably well preserved renal function, but those with bilateral or severe individual kidney damage may be considered for regular monitoring of GFR and blood pressure.

Keywords

Chronic kidney disease DMSA scan Glomerular filtration rate Hypertension Renal damage 

Abbreviations

ABPM

Ambulatory blood pressure monitoring

CKD

Chronic kidney disease

CI

Confidence interval

DMSA

99mTc-dimercaptosuccinic acid

EDTA

51Cr-edetic acid

GFR

Glomerular filtration rate

LS

Least square

MCUG

Micturating cystourethrogram

SDS

Standard deviation score

UTI

Urinary tract infection

VUR

Vesicoureteric reflux

Notes

Acknowledgments

We thank Marie Magnusson for help with GFR measurements and Aldina Pivodic for assistance with statistical calculations. Financial support was provided by grants from the West Region, Sweden and the Gothenburg Medical Society.

Funding

Financial support was provided by grants from the West Region, Sweden and the Gothenburg Medical Society.

Conflict of interest

The authors declare that they have no conflicts of interest.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© IPNA 2015

Authors and Affiliations

  • Carin Gebäck
    • 1
    • 2
    • 4
    Email author
  • Sverker Hansson
    • 1
  • Jeanette Martinell
    • 1
  • Torsten Sandberg
    • 2
  • Rune Sixt
    • 3
  • Ulf Jodal
    • 1
  1. 1.Department of Pediatrics, Institute of Clinical SciencesSahlgrenska AcademyGöteborgSweden
  2. 2.Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska AcademyUniversity of GothenburgGöteborgSweden
  3. 3.Pediatric Clinical Physiology, Institute of Clinical SciencesSahlgrenska AcademyGöteborgSweden
  4. 4.Clinical MicrobiologySahlgrenska University HospitalGöteborgSweden

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